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E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. Additionally we are shipping TRIM56 Antibodies (35) and many more products for this protein.
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TRIM56 E3 ligase-induced monoubiquitination of cGAS is important for cytosolic DNA sensing and IFNalphabeta production to induce anti-DNA viral immunity.
TRIM56 may act as a tumor suppressor in multiple myeloma through activation of TLR3 (show TLR3 Proteins)/TRIF (show TRIM69 Proteins) signaling pathway.
TRIM56 is the ubiquitin ligase that is degrading vimentin (show VIM Proteins) in ovarian cancer cells, regulation cell migration and neoplasm invasiveness.
The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis
Altogether, TRIM56 is a versatile antiviral host factor that confers resistance to yellow fever virus, dengue virus serotype 2, and human coronavirus OC43 through overlapping and distinct molecular determinants
TRIM56 is an essential component of the TLR3 (show TLR3 Proteins) antiviral signaling pathway and reveal a novel role for TRIM56 in innate antiviral immunity.
TRIM56 is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
These data demonstrate that TRIM56 is a novel antiviral host factor that restricts pestivirus infection.
TRIM56 is an interferon (show IFNA Proteins)-inducible E3 ubiquitin ligase (show MUL1 Proteins) that modulates STING to confer double-stranded DNA-mediated innate immune responses.
E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN- beta following detection of pathogen- and host-derived double- stranded DNA.
tripartite motif-containing 56
, tripartite motif-containing protein 56-like
, tripartite motif containing 56
, E3 ubiquitin-protein ligase TRIM56
, RING finger protein 109
, tripartite motif-containing protein 56