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TPM4 encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Additionally we are shipping Tropomyosin 4 Proteins (12) and Tropomyosin 4 Kits (8) and many more products for this protein.
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Human Monoclonal TPM4 Primary Antibody for IF, IHC (p) - ABIN563237
Häbig, Gellhaar, Heim, Djuric, Giesert, Wurst, Walter, Hentrich, Riess, Bonin: LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4. in Biochimica et biophysica acta 2013
TPM4 is associated with clinical progression in colon cancer patients and acts as a tumor suppressor in colon cancer cells.
Tpm4.1 is essential to maintain cell-cell adhesions and to inhibit abnormal increases in cell migration and invasion, which are important to prevent invasion and metastasis of breast cancer cells.
findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder.
In diabetes, expression of high molecular weight (HMW) isoforms from tropomyosin 1 (TPM1) were markedly decreased but HMW isoforms from tropomyosin 4 (TPM4) were not significantly different.
Results show that Tpm4.2 facilitates the transition of NM-2A to the strongly actin-binding myosin-ADP state.
In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.
Data indicate the upregulation of tropomyosin-4 in infiltrating ductal breast carcinomas (IDCAs) tissues, which may suggest its involvement in breast cancer development.
Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 with lung cancer.
TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal remodelling proteins in early pregnancy
Low TPM4 expression in the cytoplasm is associated with uterine cervix carcinogenesis.
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle.
Tm-4 is specifically enriched within and around osteoclast attachment structures, the sealing zone and podosomes.
Tropomyosin 4 defines longitudinal filaments in mouse models of muscular dystrophy and nemaline myopathy.
These results indicate that Tm-4 plays a role in regulating adhesion structures of osteoclasts, most likely by stabilizing the actin microfilaments present in podosomes and the sealing zone.
upregulation of tropomyosin 4 (TM4) mRNA is a relevant marker of dedifferentiation in vascular smooth muscle cells.
Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
, tropomyosin alpha-4 chain
, tropomycin 4