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TNNI1 encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. Additionally we are shipping TNNI1 Kits (44) and TNNI1 Proteins (13) and many more products for this protein.
Showing 10 out of 50 products:
Human Polyclonal TNNI1 Primary Antibody for WB - ABIN521026
Li, Takai, Yuge, Furukawa, Tsuno, Tsukamoto, Kong, Moriyama, Narahara: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells. in Cancer letters 2010
This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy.
investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC (show TNC Antibodies), TnI (show TNNI2 Antibodies) and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2 (show CA2 Antibodies)+)
Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex).
pathogenesis of TNNT1 myopathies
Copeptin (show AVP Antibodies) and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI (show CFD Antibodies).
TNNT1 genetic and epigenetic variations are associated with HDL (show HSD11B1 Antibodies)-C levels and coronary artery disease.
Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.
Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1.
troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants
Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT.
Mouse tumor endothelial cells express troponin T.
demonstrated that ssTnT deficiency resulted in significantly decreased levels of other slow fibre-specific myofilament proteins whereas fast fibre-specific myofilament proteins were increased correspondingly
the induction of Tnnt1 gene expression in adult mouse brains by ketamine may illustrate the genes involved in the metabolic syndromes observed in neuropsychiatric disorders
Data show that cardiac expression of slow skeletal (show MYL3 Antibodies) troponin T (Tnnt1) strictly depends on the physical interaction between GATA4 (show GATA4 Antibodies)-FOG2 (show ZFPM2 Antibodies) in the myocardium of both atria and ventricles.
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
nemaline myopathy type 5
, slow skeletal muscle troponin T
, troponin T, slow skeletal muscle
, troponin-T1, skeletal, slow
, troponin I, skeletal, slow
, troponin I type 1 (skeletal, slow)
, troponin I, skeletal, slow 1
, troponin T1, skeletal, slow
, troponin T slow type isoform sTnT1
, skeletal muscle slow-twitch TnT