anti-Troponin T2, Cardiac (TNNT2) Antibodies

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Additionally we are shipping Cardiac Troponin T2 Kits (41) and Cardiac Troponin T2 Proteins (31) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNNT2 7139 P45379
TNNT2 21956 P50752
TNNT2 24837 P50753
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Top anti-Cardiac Troponin T2 Antibodies at antibodies-online.com

Showing 10 out of 318 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TNNT2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Muscle Host:  Mouse  Target Name:  TNNT2  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of cTnT expression in H9 (A), 4T1 (B), human heart (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Chicken Mouse Un-conjugated IF, IHC, IHC (p) Human Rabbit Heart (formalin-fixed, paraffin-embedded) stained with TNNT2 antibody ABIN462337 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-TNNT2 / CTnT antibody IHC of human rabbit heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 50 μL 11 to 14 Days
$484.00
Details
Chicken Mouse Un-conjugated IF, IHC, IHC (p) Anti-TNNT2 / Cardiac Troponin T antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. 250 μL 11 to 14 Days
$786.50
Details
Human Mouse Un-conjugated FACS, ELISA, WB 100 μL 11 to 16 Days
$469.05
Details
Cat Mouse Un-conjugated ELISA, IHC, IHC (p) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TNNT2 / CTnT antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TNNT2 / CTnT antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.1 mg 11 to 14 Days
$592.90
Details

Top referenced anti-Cardiac Troponin T2 Antibodies

  1. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody for ICS - ABIN2688864 : Jáchymová, Muravská, Paleček, Kuchynka, Řeháková, Magage, Kr��l, Zima, Horký, Linhart: Genetic variation screening of TNNT2 gene in a cohort of patients with hypertrophic and dilated cardiomyopathy. in Physiological research / Academia Scientiarum Bohemoslovaca 2012 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody for IHC (f), ICS - ABIN2688865 : Lian, Hsiao, Wilson, Zhu, Hazeltine, Azarin, Raval, Zhang, Kamp, Palecek: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 7 Pubmed References

  3. Mammalian Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Capture), ELISA - ABIN191341 : Feng, Taggart, Hall, Bryant, Sansone, Kemmerer, Herlich, Lord: Limited additional release of cardiac troponin I and T in isoproterenol-treated beagle dogs with cardiac injury. in Clinical chemistry 2005 (PubMed)
    Show all 6 Pubmed References

  4. Mammalian Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Detection), ELISA - ABIN191349 : Goette, Arndt, Röcken, Staack, Bechtloff, Reinhold, Huth, Ansorge, Klein, Lendeckel: Calpains and cytokines in fibrillating human atria. in American journal of physiology. Heart and circulatory physiology 2002 (PubMed)
    Show all 6 Pubmed References

  5. Human Polyclonal Cardiac Troponin T2 Primary Antibody for IP, IHC - ABIN191343 : Hammerer-Lercher, Erlacher, Bittner, Korinthenberg, Skladal, Sorichter, Sperl, Puschendorf, Mair: Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy. in Clinical chemistry 2001 (PubMed)
    Show all 6 Pubmed References

  6. Human Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Capture), ELISA - ABIN263480 : Nakaura, Morimoto, Yanaga, Nakata, Nishi, Imaizumi, Ohtsuki: Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy. in The American journal of physiology 1999 (PubMed)
    Show all 6 Pubmed References

  7. Human Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA - ABIN263478 : Urasawa, Wada, Machida, Yuasa, Shimatsu, Wakao, Yuasa, Sano, Nonaka, Nakamura, Takeda: Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. in Circulation 2008 (PubMed)
    Show all 6 Pubmed References

  8. Human Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA - ABIN263477 : van den Berg, Abu-Issa, de Boer, Hutson, de Boer, Soufan, Ruijter, Kirby, van den Hoff, Moorman: A caudal proliferating growth center contributes to both poles of the forming heart tube. in Circulation research 2009 (PubMed)
    Show all 6 Pubmed References

More Antibodies against Cardiac Troponin T2 Interaction Partners

Human Troponin T2, Cardiac (TNNT2) interaction partners

  1. Positive high sensitivity troponin-T results are associated with poor outcomes in intubated patients with traumatic brain injury.

  2. Studies suggest that most humans have cardiac troponin T cTn circulating in the blood due to a more or less constant release from the myocardium into the circulation.

  3. -Terminal Truncation of Cardiac Troponin T Alters Function at Low and Saturating Ca(2)

  4. The higher the cTnT blood concentrations, the higher is the likelihood for non-ST-segment elevation myocardial infarction also in patients with acute coronary syndrome probability.

  5. more than 2-fold higher in subjects with heart failure and preserved ejection fraction at rest and during exercise

  6. the effects of the TnT-I79N mutation in human cardiomyocytes, were studied.

  7. The hs-TnT values were affected by various factors and culminated around the first 24 h following off-pump coronary artery bypass grafting.

  8. to evaluate the incidence of Perioperative Myocardial Injury (myocardial ischemia) as assessed by high-sensitivity cardiac troponin T

  9. Elevated hs-cTnT levels were observed in severe obstructive sleep apnea patients without cardiovascular disease.

  10. The increase in TnT during Immersion pulmonary edemamay be secondary to the release of troponin from non-cardiac origin. The measurement of TnI in place of TnT permits in some cases to avoid additional examinations, especially unnecessary invasive investigations

  11. Serum levels of troponin T (and troponin I) are related to heart failure and left ventricular hypertrophy in hemodialysis patients.

  12. [Pulsed electric fields inhibit tumor growth but induce myocardial injury of melanoma-bearing mice].

  13. review exploring mechanisms that may lead to cTn elevations

  14. NT-proBNP and hs-cTnT are useful biomarkers in assessment of hypertrophy and fibrosis in hypertrophic cardiomyopathy.

  15. Data suggest that clinical characteristics can be used to identify low risk patients with acute chest pain and Normal high sensitivity cardiac troponin (hs-cTn) levels.

  16. Troponin-T mutation is associated with Hypertrophic cardiomyopathy.

  17. These data suggest that associations of high-sensitivity cardiac troponin I and high-sensitivity cardiac troponin T with cardiac injury detected by electrocardiography are driven by different mechanisms.

  18. Serum cardiac troponin T associated with cardiovascular complications after heart transplantation.

  19. Troponin T is neither specific nor useful as cardiac biomarker for post mortem sample

  20. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis].

Mouse (Murine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling.

  2. Hypertrophic cardiomyopathy pathophysiology is "mutation specific" in mice models carrying TNNT2 E163R and R92Q mutations.

  3. TnTA30V mutation attenuated Ca(2+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin heavy chain but augmented these parameters against beta-myosin heavy chain, suggesting divergent contractile phenotypes.

  4. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A overexpression.

  5. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT, Ca(2+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  6. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain

  7. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  8. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  9. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  10. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  11. TnT mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 and hypertrophic cardiomyopathy in the presence of MYH7.

  12. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

  13. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

  14. Mice carrying the Delta160E or E163R mutations exhibit sarcomeric disruption.

  15. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T.

  16. Study is the first to show that the interplay between the N terminus of cTnT and the overlapping ends of contiguous Tm effectuates different states of Tm on the actin filament.

  17. We conclude that the observed clinical severity of the cTnT Delta160E mutation is caused by a combination of direct sarcomeric disruption coupled to a profound dysregulation of Ca(2+) homeostasis

  18. Report two distinct functional regions within the N-terminus of cTnT with divergent roles in mediating cardiac contractile activation.

  19. Data show that cardiac TnI gene transition and the alternatively spliced cardiac TnT isoform switching occur in postnatal pulmonary vein.

  20. findings provide new evidence to demonstrate that R92 mutation effects on cardiac contractile function and dynamics are influenced by myosin heavy chain isoform

Zebrafish Troponin T2, Cardiac (TNNT2) interaction partners

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Rabbit Troponin T2, Cardiac (TNNT2) interaction partners

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Cardiac Troponin T2 (TNNT2) Antigen Profile

Protein Summary

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Gene names and symbols associated with TNNT2

  • troponin T2, cardiac type (TNNT2) antibody
  • troponin T2, cardiac (Tnnt2) antibody
  • troponin T2, cardiac type (Tnnt2) antibody
  • troponin T type 2a (cardiac) (tnnt2a) antibody
  • troponin T2, cardiac type L homeolog (tnnt2.L) antibody
  • troponin T2e, cardiac (tnnt2e) antibody
  • CMH2 antibody
  • CMPD2 antibody
  • CT3 antibody
  • cTnT antibody
  • Ctt antibody
  • CTTG antibody
  • LVNC6 antibody
  • RATCTTG antibody
  • RCM3 antibody
  • si:ch211-136g2.1 antibody
  • tnnt2 antibody
  • Tnnt3 antibody
  • Tnt antibody
  • TnTC antibody

Protein level used designations for TNNT2

cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , troponin T, cardiac muscle , troponin T2, cardiac , cardiac TnT , cardiac muscle troponin T , tnTc , Troponin T cardiac , cTnT , cardiac troponin T2 , sih , silent heart , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , cardiac troponin T , troponin T type 2, cardiac , cardiac troponin 2 , Troponin T, cardiac muscle , troponin T cardiac isoform , novel slow skeletal troponin T family protein , troponin T2e, cardiac

GENE ID SPECIES
7139 Homo sapiens
21956 Mus musculus
24837 Rattus norvegicus
58071 Danio rerio
286816 Bos taurus
396433 Gallus gallus
403532 Canis lupus familiaris
493940 Felis catus
100379561 Cavia porcellus
398518 Xenopus laevis
100622450 Sus scrofa
100009428 Oryctolagus cuniculus
556703 Danio rerio
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