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Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Additionally we are shipping TDRD3 Proteins (3) and and many more products for this protein.
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Study reports TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Its depletion inhibits tumor formation and metastasis to the lung in vivo. Furthermore, TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression at the level of translation.
Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported.
Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast.
The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively.
The TDRD3 is an effector molecule that promotes transcription by binding methylarginine marks on histone tails.
Tudor domain of TDRD3 was required for its recruitment to cytoplasmic stress granules.
propose a contribution of Tdrd3 to FMRP-mediated translational repression and suggest that the loss of the FMRP-Tdrd3 interaction caused by the I304N mutation might contribute to the pathogenesis of Fragile X syndrome
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine- methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity).
tudor domain containing 3
, tudor domain-containing protein 3