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The protein encoded by TNFRSF8 is a member of the TNF-receptor superfamily.
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Data suggest that CD4 (show CD4 Proteins)+ T cell-associated HIV-1 RNA is often highly enriched in cells expressing CD30; cells expressing this marker considerably contribute to total pool of transcriptionally active CD4 (show CD4 Proteins)+ lymphocytes in individuals on suppressive anti-retroviral drug therapy; CD30 may be a marker of residual, transcriptionally active HIV-1 infected cells in blood and in gut (show GUSB Proteins)-associated lymphoid tissue.
The stable elevation in classical Hodgkin lymphoma risk with elevated levels of sCD30 and IL6 (show IL6 Proteins) across 4 or more years prior to diagnosis may also reflect a B-cell-stimulatory environment that promotes the genesis of these cancers.
extranodal NK/T-cell lymphoma, nasal type(ENKTL) is the most common type of mature T-cell and NK-cell lymphoma diagnosed at our institution. CD30 is frequently expressed in ENKTL and represents a therapeutic target; however, it may not be a prognostic marker.
This study suggests that in patients with CD30+ lymphoproliferative disorders, an aggressive clinical course cannot be defined by the presence of TP63 rearrangements, as was recently shown in systemic ALK negative anaplastic large cell lymphoma.
Data suggest that Brentuximab Vedotin (SGN-35) damaged CD30 ligand (CD30L (show TNFSF8 Proteins))-immune cells through CD30 extracellular vesicles (EVs).
median FoxP3 (show FOXP3 Proteins)+ Treg count was higher in CD30+ than in CD30- posttransplant lymphoproliferative disorders, 3.0 vs 0
Variant histology is common in pediatric NLPHL, especially types C and E, which are associated with IgD expression. Type C variant histology and possibly type D are associated with decreased EFS (show EFS Proteins), but neither IgD nor CD30 are adverse features. Variant histology may warrant increased surveillance, but did not affect overall survival.
Expression of CD30 in patients with both DLBCL and other aggressive B-cell lymphomas and the absence of MYC (show MYC Proteins) oncogene (show RAB1A Proteins)-driven proliferation in the majority of these tumors suggests that brentuximab may be a particularly effective form of targeted therapy in the subset of patients with high CD30 expression.
Prevalence of the CD30 (Ki-1) antigen in human solid tumors was summarized.
CD30 expression was detected in up to 25% of cases of diffuse large B-cell lymphoma and was more frequent in tumors without MYC (show MYC Proteins) rearrangement. CD30 expression was not associated with overall survival in R-EPOCH-treated de novo DLBCL patients.
This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 (show CD4 Proteins) T cells at the induction phase of experimental autoimmune encephalomyelitis.
Data indicate that CD30L (show TNFSF8 Proteins)/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).
role in the maintenance and activation of IL-17A (show IL17A Proteins)-producing gammadelta T cells
These results suggest that CD30 signaling plays an important role in the activation of IL-17A (show IL17A Proteins)-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG (show SLC11A1 Proteins) infection.
Interference of the CD30-CD30L (show TNFSF8 Proteins) pathway reduces atherosclerosis development.
CD30L (show TNFSF8 Proteins)/CD30 pathway acts as an accelerator of enteritis in a murine disease model
role of CD30L (show TNFSF8 Proteins)/CD30 interactions in allergic rhinitis; results suggest that CD30L (show TNFSF8 Proteins) plays an important role in allergic rhinitis
Abrogation of CD30 and OX40 (show TNFRSF4 Proteins) signals prevents autoimmune disease in FoxP3 (show FOXP3 Proteins)-deficient mice.
Studies demonstrate that CD30L (show TNFSF8 Proteins)/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation.
CD30 can signal in a completely TCR-independent fashion to induce IL-13 (show IL13 Proteins) production by effector T cells.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, Ki-1 antigen
, cytokine receptor CD30
, lymphocyte activation antigen CD30
, tumor necrosis factor receptor superfamily member 8
, Tumor necrosis factor superfamily member 8
, tumor necrosis factor superfamily, member CD30
, tumor necrosis factor receptor superfamily, member 8
, tumor necrosis factor receptor superfamily member 8-like