anti-Tumor Protein P63 (TP63) Antibodies

TP63 encodes a member of the p53 family of transcription factors. Additionally we are shipping p63 Kits (17) and p63 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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Top anti-p63 Antibodies at

Showing 10 out of 133 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Anti-p63 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Anti-p63 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: SMMC Cell Lysate Lane 3: COLO320 Cell Lysate Lane 4: A549 Cell Lysate Lane 5: SGC Cell Lysate 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ICC, IHC (p), WB Anti-p63 Picoband antibody,  IHC(P): Human Oesophagus Squama Cancer Tissue Anti-p63 Picoband antibody,  All lanes: Anti P63  at 0.5ug/ml WB: Recombinant Human P63 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg 4 to 6 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of COS7 cell lysate, using TP63  Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277119 staining  HeLa cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using TP63 antibody. 100 μL 13 to 14 Days
Human Mouse Un-conjugated WB Western blot analysis of extracts of various cell lines, using TP63 antibody (ABIN4904650) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s. 100 μL 11 to 13 Days
Human Rabbit Un-conjugated WB Western Blot at 1:1000 dilution + HACAT whole cell lysate Lysates/proteins at 20 ug per lane. 400 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Human p63 / TP63 Western blot (WB) 13067 100 μL 14 to 16 Days
Human Rabbit Un-conjugated IHC (p) Immunochemical staining of human P63 in human skin with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). 100 μL 14 to 16 Days

Top referenced anti-p63 Antibodies

  1. Human Monoclonal p63 Primary Antibody for IHC, WB - ABIN2673817 : Zhang, Wei, Dang, Xie, Zhong, Ma, Chen: Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report. in International journal of clinical and experimental pathology 2015 (PubMed)
    Show all 2 Pubmed References

More Antibodies against p63 Interaction Partners

Human Tumor Protein P63 (TP63) interaction partners

  1. the mRNA expression levels of TAp63 and DeltaNp63 in 40 normal, 30 low-grade squamous intraepithelial lesions, 38 high-grade squamous intraepithelial lesions, and 52 cervical cancer formalin-fixed paraffin-embedded tissues were examined

  2. Molecular mechanisms of p63-mediated squamous cancer pathogenesis have been described. (Review)

  3. These results demonstrated that, beside contributing to cell cycle exit, TAp63gamma participates to myoblasts metabolism control.

  4. expression of the transcription factor TP63 (DeltaNp63) is sufficient to install and sustain the enhancer landscape and transcriptional signature of the squamous lineage in human pancreatic ductal adenocarcinoma cells.

  5. YAP and DeltaNp63 expression levels correlated with grade of oral epithelial dysplasia. Additionally, YAP expression was associated with oral squamous cell carcinoma (OSCC) survival rate. Results suggested that YAP and DeltaNp63 expression might serve as predictive markers to distinguish OSCC development and progression.

  6. DeltaNp63alpha controls cell proliferation in squamous cell carcinomas via TGFB2 and RHOA pathway.

  7. we observed that the genetic variant rs10937405 of TP63 gene is associated with an increased risk of NSCLC in north Indian population.

  8. These findings identify a disease mechanism whereby mutant p63 rewires the enhancer landscape and affects epidermal cell identity.

  9. results were related to endogenous p63-p300 complex formation and Wnt/beta-catenin-responsive gene regulation by p63 in squamous cell carcinoma lines

  10. DeltaNup63 loss is associated with adverse outcome of NMIBC.

  11. Ablation of DeltaNp63 alpha leads to cell cycle arrest and growth retardation, due to, in part, upregulation of p38 MAPK phosphorylation and activation.

  12. Overexpression of DeltaNp63gamma modulates cell invasion by inducing targetable SRC-Slug-evoked epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma , which can be reversed by inhibitors of the SRC signaling.

  13. p38alpha destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential

  14. The data illuminate a novel axis regulating cell senescence: DeltaNp63alpha stimulates transcription of E3 ligase HERC3, which mediates ubiquitination of c-Myc modulator MM1 and targets it to proteasomal degradation; subsequently, c-Myc is derepressed by DeltaNp63alpha, thereby cell senescence is modulated by this axis.

  15. CKAP4 has a role in esophageal cancer cell proliferation through p63 dependent DKK3 expression

  16. We identified rare damaging variants in four genes known to be mutated in syndromic lip and/or cleft palate (syCL/P) : TP63 (one family), TBX1 (one family), LRP6 (one family) and GRHL3 (two families), and clinical reassessment confirmed the isolated nature of their lip and/or cleft palate (CL/P).

  17. These results showed tumor-suppressive roles of DeltaNp63beta and miR-205 by inhibiting epithelial-to-mesenchymal transition (EMT) thorough modulating ZEB1 and ZEB2 expression in oral squamous cell carcinoma

  18. we found that human lung epithelial (HuL) cells, derived from normal, peripheral lung tissue, in monolayer, mostly express both the N-terminally truncated isoform of p63 (Np63), a marker for airway basal cells, and thyroid transcription factor-1 (TTF-1), a marker for alveolar epithelial cells, even though these two molecules are usually expressed in a mutually exclusive way.

  19. These findings identify a unique crosstalk between DeltaNp63+ TNBC cells and MDSCs that promotes tumor progression and metastasis, which could be exploited in future combined immunotherapy/chemotherapy strategies for TNBC patients.

  20. Study comparing p63/p40 expression with myoepithelial markers in minor salivary gland tumors revealed that p63 expression is almost comparable with VIM in detecting myoepithelial cells, an immunolabeling pattern not followed by p40, and consequently, caution has to be taken during the interpretation of salivary gland tumor exhibiting an p63/p40 phenotype in order to avoid a misdiagnosis.

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. During early zebrafish embryonic development, p63 binds to enhancers associated to neural plate-expressing genes, where it limits Sox3 binding and neural gene expression. p63 binds enhancers associated to epidermis-expressing genes when they are in a non-accessible chromatin state, leading to its opening and epidermal gene expression.

  2. they unravel essential roles of TAp63 and p53 to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch signalling and caspase 3 activity.

  3. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma transcription in response to ER stress.

  4. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  5. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  6. rps19-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. Studied role of transformation related protein 63 (p63) inactivation thru gene silencing in reprogramming of cardiac cells; found downregulation of p63 facilitates cell reprogramming of cardiac fiibroblasts to cardiomyocytes.

  2. GSK-3beta was essential for sustaining fetal oocyte survival and folliculogenesis via fine-tuning the cytoplasmic-nuclear translocation of beta-catenin, which in turn modulates timely TAp63 expression during meiotic prophase I in mice.

  3. P63 mediates the apoptosis of male germ cells and regulates three stages of spermatogenesis transcriptionally.

  4. Letter: loss of TP63/TRP63 directly facilitates cutaneous squamous cell carcinoma development and progression through activation of Wnt/beta-catenin signaling.

  5. Altogether, these results demonstrate that CCDC3 modulates liver lipid metabolism by inhibiting liver de novo lipogenesis as a downstream player of the p63 network.

  6. TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis

  7. Down-regulation of p63 attenuates liver steatosis in p53 knockout mice and in diet-induced obese mice, whereas the activation of p63 induces lipid accumulation.

  8. Low TP63 expression is associated with neoplasms.

  9. The results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

  10. Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.

  11. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  12. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 and IL-33 are key players in the signaling pathways.

  13. cells expressing both p63 and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  14. Data suggest that this the selective targeting of genes by tumor suppressor protein p63 (p63) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  15. Using a combination of biophysical methods as well as cell and ovary culture experiments the authors explain how TAp63alpha is kept inactive in the absence of DNA damage but causes rapid oocyte elimination in response to a few DNA double strand breaks thereby acting as the key quality control factor in maternal reproduction.

  16. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion

  17. TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway

  18. controls limb development through transcriptional regulation of different target molecules with different roles in the apical ectodermal ridge

  19. these results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs.

  20. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.

  3. The role of p63 as a negative Wnt-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Antigen Profile

Protein Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with TP63

  • tumor protein p63 (TP63) antibody
  • tumor protein p63 (tp63) antibody
  • tumor protein p63 (Tp63) antibody
  • transformation related protein 63 (Trp63) antibody
  • tumor protein p63 L homeolog (tp63.L) antibody
  • AI462811 antibody
  • AIS antibody
  • B(p51A) antibody
  • B(p51B) antibody
  • DNp63 antibody
  • EEC3 antibody
  • id:ibd3516 antibody
  • ket antibody
  • LMS antibody
  • NBP antibody
  • np63 antibody
  • OFC8 antibody
  • p40 antibody
  • p51 antibody
  • P51/P63 antibody
  • p53CP antibody
  • P63 antibody
  • p73H antibody
  • P73l antibody
  • RHS antibody
  • SHFM4 antibody
  • TP53CP antibody
  • TP53L antibody
  • Tp63 antibody
  • Tp73l antibody
  • tp73l-A antibody
  • Trp53rp1 antibody
  • trp63 antibody
  • wu:fc89f04 antibody
  • wu:fk85h07 antibody
  • wu:fk88b02 antibody
  • Xp63 antibody

Protein level used designations for TP63

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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