p63 antibody (Tumor Protein P63) (AA 651-680)

Details for Product anti-TP63 Antibody No. ABIN657886, Supplier: Log in to see
Antigen
  • AIS
  • B(p51A)
  • B(p51B)
  • EEC3
  • KET
  • LMS
  • NBP
  • OFC8
  • RHS
  • SHFM4
  • TP53CP
  • TP53L
  • TP73L
  • p40
  • p51
  • p53CP
  • p63
  • p73H
  • p73L
  • TP63
  • tp63
  • DNp63
  • id:ibd3516
  • tp73l
  • wu:fc89f04
  • wu:fk85h07
  • wu:fk88b02
  • Ket
  • P73l
  • Tp73l
  • Trp63
  • TRP63
  • AI462811
  • P51/P63
  • P63
  • Tp63
  • Trp53rp1
  • Xp63
  • ket
  • np63
  • tp73l-A
  • trp63
  • tumor protein p63
  • transformation related protein 63
  • tumor protein p63 L homeolog
  • TP63
  • tp63
  • Tp63
  • Trp63
  • tp63.L
Epitope
AA 651-680, C-Term
14
7
6
5
4
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
82
25
21
2
2
Host
Rabbit
60
22
3
Clonality (Clone)
Polyclonal ()
Conjugate
This p63 antibody is un-conjugated
1
1
1
1
1
1
Application
Western Blotting (WB)
71
38
21
14
9
8
7
5
4
1
Options
Supplier
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Immunogen This TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 651-680 AA from the C-terminal region of human TP63.
Clone RB30257
Isotype Ig Fraction
Specificity This TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 650-680 amino acids from the C-terminal region of human TP63.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Plasmids, Primers & others Plasmids, Primers & others p63 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TP63 (TP63 Antibody Abstract)
Background This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Synonyms: Tumor protein 63,8626,KET, P63, P73H, P73L, TP73L
Molecular Weight 76785 DA
Gene ID 8626
NCBI Accession NP_003713, NP_001108451, NP_001108452
UniProt Q9H3D4
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TP63 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Tumor Protein P63 (TP63) (AA 651-680), (C-Term) antibody (ABIN657886) TP63 Antibody (C-term) (ABIN657886) western blot analysis in MDA-MB231 cell line lysa...
Western Blotting (WB) image for anti-Tumor Protein P63 (TP63) (AA 651-680), (C-Term) antibody (ABIN657886) Anti-TP63 Antibody (C-term) at 1:1000 dilution + HACAT whole cell lysate Lysates/prot...
Product cited in: Zamudio, Wang, Chung, Wolosin: "Inhibition of TGF? cell signaling for limbal explant culture in serumless, defined xeno-free conditions." in: Experimental eye research, Vol. 145, pp. 48-57, 2015 (PubMed).

Background publications Miki, Kubo, Takahashi, Yoon, Kim, Lee, Zo, Lee, Hosono, Morizono, Tsunoda, Kamatani, Chayama, Takahashi, Inazawa, Nakamura, Daigo: "Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations." in: Nature genetics, Vol. 42, Issue 10, pp. 893-6, 2010 (PubMed).

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