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This intronless gene encodes a carcinoma-associated antigen. Additionally we are shipping TACSTD2 Proteins (18) and TACSTD2 Kits (2) and many more products for this protein.
Showing 10 out of 173 products:
Human Polyclonal TACSTD2 Primary Antibody for CyTOF, FACS - ABIN4900496
Ambrogi, Fornili, Boracchi, Trerotola, Relli, Simeone, La Sorda, Lattanzio, Querzoli, Pedriali, Piantelli, Biganzoli, Alberti: Trop-2 is a determinant of breast cancer survival. in PLoS ONE 2014
Show all 9 Pubmed References
Mouse (Murine) Polyclonal TACSTD2 Primary Antibody for CyTOF, FACS - ABIN4900492
Eisenwort, Jurkin, Yasmin, Bauer, Gesslbauer, Strobl: Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-?1-dependent human epidermal Langerhans cells. in The Journal of investigative dermatology 2011
Show all 6 Pubmed References
Human Monoclonal TACSTD2 Primary Antibody for FACS, IHC - ABIN2689944
Bobos, Kotoula, Kaloutsi, Karayannopoulou, Papadimitriou, Kostopoulos: Aberrant CCND1 copies and cyclin D1 mRNA expression do not result in the production of functional cyclin D1 protein in anaplastic large cell lymphoma. in Histology and histopathology 2009
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Human Monoclonal TACSTD2 Primary Antibody for CyTOF, FACS - ABIN4900015
Yamaguchi, Nishii, Nakamura, Aoki, Hirai, Uchida, Sakuma, Hamada: Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells. in Biochemical and biophysical research communications 2016
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Human Monoclonal TACSTD2 Primary Antibody for CyTOF, FACS - ABIN4900016
Frederick, Helfrich, Coldren, Zheng, Chan, Bunn, Raben: Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. in Molecular cancer therapeutics 2007
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Human Monoclonal TACSTD2 Primary Antibody for FACS - ABIN4897042
Hussain, Lawrence, Taylor, Lo, Frydenberg, Ellem, Furic, Risbridger: Estrogen receptor β activation impairs prostatic regeneration by inducing apoptosis in murine and human stem/progenitor enriched cell populations. in PLoS ONE 2012
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Human Polyclonal TACSTD2 Primary Antibody for IF (p) - ABIN918712
Zhou, Copeland, Otto-Duessel, He, Markel, Synold, Jones: Low Testosterone Alters the Activity of Mouse Prostate Stem Cells. in The Prostate 2016
Human Polyclonal TACSTD2 Primary Antibody for ELISA, WB - ABIN316346
Shimada, Kano, Ishiyama, Okubo, Iijima, Morishita, Minami, Inadome, Shu, Sugita, Takeuchi, Noguchi: Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. in Cancer science 2005
Mouse (Murine) Polyclonal TACSTD2 Primary Antibody for FACS - ABIN4897798
Stoyanova, Goldstein, Cai, Drake, Huang, Witte: Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. in Genes & development 2012
Stress fibre formation and up-regulation of alpha-smooth muscle actin (show ACTG2 Antibodies) (alphaSMA (show ACTA2 Antibodies)) induced by TGFbeta2 could be reversed by Tpm1 (show TPM1 Antibodies)/2 knock-down by siRNA.
Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program.
Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa (show ENPP1 Antibodies) cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa (show ENPP1 Antibodies).
studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.
our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells
data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK (show EPHB2 Antibodies) pathway and several critical components of the cell migration apparatus
Trop2 plays a cardioprotective role by promoting cardiac c-kit (show KIT Antibodies)+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
Trop2 is a regulator of self-renewal, proliferation, and transformation
TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.
Results show that TROP2 expression is up-regulated in gastric tumor and its co-expression with AREG (show AREG Antibodies) protein is associated with TNM (show ODZ1 Antibodies) stage, tumor size, lymph node metastases, and distant metastases.
Our findings indicate that the expression of Trop-2 is a stringent predictor of tumor response to AKT (show AKT1 Antibodies) inhibitors. They also support the identification of target-activatory pathways, as efficient predictors of response in precision cancer therapy.
Findings suggest that high TROP2 expression identifies distinct cell sub-populations in androgen-sensitive and androgen-independent prostate tumors and that it may be a predictive biomarker for prostate cancer treatment response in androgen-sensitive tumors.
TROP2 may play a crucial role in COPD (show ARCN1 Antibodies) by affecting basal cells function and thus airway remodeling through increased basal cells hyperplasia
TROP2 was overexpressed specifically in the majority of epithelial ovarian cancer and may be a novel prognostic biomarker
we compared the diagnostic value of TROP-2 expression in distinguishing between benign and malignant thyroid lesions to those of HBME-1, CK19 (show KRT19 Antibodies) and galectin-3 (show LGALS3 Antibodies)
TROP-2 membranous staining is a very sensitive and specific marker for the classic and tall cell variants of papillary thyroid carcinoma, and for papillary microcarcinomas , with high overall specificity for papillary thyroid carcinoma
The results suggested that trop2 facilitated neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway.
We identified a homozygous TACSTD2 missense mutation, c.551A>G, p.(Tyr184Cys), in the affected family members. Both parents were heterozygous for the mutation, and unaffected siblings were either heterozygous or homozygous wild-type for this allele.
Our results expand the mutational spectrum of TACSTD2 in patients with gelatinous drop-like corneal dystrophy (GDLD).
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
tropomyosin beta chain
, 40kD glycoprotein, identified by monoclonal antibody GA733
, cell surface glycoprotein TROP2
, cell surface glycoprotein Trop-2
, epithelial glycoprotein-1
, gastrointestinal tumor-associated antigen GA7331
, membrane component chromosome 1 surface marker 1
, membrane component, chromosome 1, surface marker 1
, pancreatic carcinoma marker protein GA733-1
, pancreatic carcinoma marker protein GA7331
, lymphocyte antigen 97
, tunor-associated calcium signal transducer 2
, parturition-related protein 1