Tyrosinase Proteins (TYR)

The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Additionally we are shipping Tyrosinase Antibodies (292) and Tyrosinase Kits (64) and many more products for this protein.

Gene Name	GeneID	UniProt
TYR	7299	P14679
TYR	22173	P11344
TYR	308800

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Top Tyrosinase Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3132843	Insect Cells	Mouse	rho-1D4 tag	0.25 mg	Log in to see	50 to 55 Days	$5,355.45	Details
ABIN3075088	Insect Cells	Human	rho-1D4 tag	0.5 mg	Log in to see	50 to 55 Days	$7,626.01	Details
ABIN2122298	Escherichia coli (E. coli)	Wild boar	His tag	100 μg	Log in to see	15 to 18 Days	$704.00	Details
ABIN5710578	Escherichia coli (E. coli)	Human	His-SUMO Tag	100 μg	Log in to see	11 Days	$411.40	Details
ABIN5713924	Yeast	Human	His tag	100 μg	Log in to see	8 to 11 Days	$484.00	Details
ABIN2734714	HEK-293 Cells	Human	Myc-DYKDDDDK Tag	20 μg	Log in to see	Available	$814.00	Details
ABIN3012116	Escherichia coli (E. coli)	Pig	Un-conjugated	100 μg	Log in to see	11 to 18 Days	$639.61	Details
ABIN1324261	Wheat germ	Human	GST tag	2 μg	Log in to see	11 to 12 Days	$338.33	Details
ABIN1458643	Yeast	Cat	His tag	1 mg	Log in to see	60 to 71 Days	$2,113.83	Details
ABIN1610996	Yeast	REACT_Pelodiscus sinensis japonicus	His tag	1 mg	Log in to see	60 to 71 Days	$2,656.50	Details

TYR Proteins by Origin and Source

Origin	Expressed in	Conjugate
Human	, , , ,	, , , ,
Mouse (Murine)		,
Rat (Rattus)

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More Proteins for Tyrosinase (TYR) Interaction Partners

Zebrafish Tyrosinase (TYR) interaction partners

Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.

Atlantic Salmon (Salmo salar) Tyrosinase (TYR) interaction partners

Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK (show SHPK Proteins)-1) is influenced by temperature, but not by virus infection or bacterin stimulation.

Human Tyrosinase (TYR) interaction partners

The effect of histidine mutations on the structural stability of human tyrosinase leading to albinism has been reported.
Compound heterozygous mutations (c.832C>T and c.929_930insC) in the TYR gene may be responsible for partial clinical manifestations of oculocutaneous albinism
Mutations in tyrosinase gene is associated with Oculocutaneous albinism type 1.
tyrosinase as a potential GPR143 (show GPR143 Proteins) binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.
Aberrant tyrosinase expression in an atypical fibroxanthoma
Findings suggested that miR (show MLXIP Proteins)-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 (show PDIA3 Proteins) expression.
Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage
LEF-1 (show LEF1 Proteins) and MITF (show MITF Proteins) regulate tyrosinase gene transcription in vitro via binding to its promoter.
Data show that mutant microphthalmia-associated transcription factor (MITF (show MITF Proteins)) with loss of localization signals (NLS (show ALDH1A2 Proteins)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.
The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app (show APP Proteins). 60%) albinism patients.

Mouse (Murine) Tyrosinase (TYR) interaction partners

This study demonstrates the utility of CRISPR-Cas9 system in generating domain-specific in-frame deletions and helps gain further insights into structure-function of Tyr gene.
These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.
Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.
STAP-2 (show STAP2 Proteins) colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.
Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.
Studied upregulation by Kaliziri extract of tyrosinase, TRP-1 (show TRPC1 Proteins), TRP-2 (show DCT Proteins) and MITF (show MITF Proteins) expression in murine B16 melanoma cells.
The albino mutation of tyrosinase alters ocular angiogenic responsiveness.
Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.
activated by ascorbic acid in B16 melanoma via p38 MAPK (show MAPK14 Proteins) signaling and upregulation of melanogenic regulatory factors
Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells

Guinea Pig Tyrosinase (TYR) interaction partners

the missense mutation (c.710A>G; p.Asp237Gly) in the TYR gene is associated with the albino phenotype in guinea pig

Rabbit Tyrosinase (TYR) interaction partners

we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1 (show TYRP1 Proteins)) and Tyrosinase (TYR), as well as genes with unknown functions.

Tyrosinase (TYR) Protein Profile

Protein Summary

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Gene names and symbols associated with Tyrosinase Proteins (TYR)

tyrosinase (tyr)
TYRosinase (tyr-5)
tyrosinase S homeolog (tyr.S)
tyrosinase (TYR)
tyrosinase (Celal_3121)
tyrosinase (Halhy_4121)
tyrosinase (Mesop_2736)
tyrosinase (LOC100136546)
tyrosinase (Tyr)

albino protein
C protein
CMM8 protein
LOC100136546 protein
OCA1A protein
OCAIA protein
sandy protein
SHEP3 protein
skc35 protein
tyr protein
TYRO protein
zgc:109705 protein

Protein level used designations for Tyrosinase Proteins (TYR)

oca1 , sdy , tyra , hypothetical protein , tyrosinase (oculocutaneous albinism IA) , tyrosinase , monophenol monooxygenase , tyrosinase-like , LB24-AB , SK29-AB , oculocutaneous albinism IA , tumor rejection antigen AB , albino locus protein

GENE ID	SPECIES
30207	Danio rerio
189907	Caenorhabditis elegans
398715	Xenopus laevis
451473	Pan troglodytes
705792	Macaca mulatta
10145547	Cellulophaga algicola DSM 14237
10588308	Haliscomenobacter hydrossis DSM 1100
10826573	Mesorhizobium opportunistum WSM2075
100049427	Oryzias latipes
100125152	Xenopus (Silurana) tropicalis
100135825	Oncorhynchus mykiss
100136546	Salmo salar
100453479	Pongo abelii
100594055	Nomascus leucogenys
7299	Homo sapiens
22173	Mus musculus
308800	Rattus norvegicus
100713552	Cavia porcellus
403405	Canis lupus familiaris
751100	Felis catus
100008753	Oryctolagus cuniculus
407745	Sus scrofa
280951	Bos taurus
373971	Gallus gallus
780502	Ovis aries

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