Tyrosinase  Proteins (TYR)

The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Additionally we are shipping Tyrosinase  Antibodies (292) and Tyrosinase  Kits (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TYR 7299 P14679
TYR 22173 P11344
TYR 308800  
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Top Tyrosinase  Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
Yeast Human His tag 100 μg Log in to see 8 to 11 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Escherichia coli (E. coli) Pig Un-conjugated SDS-PAGE analysis of Pig Tyrosinase Protein. 100 μg Log in to see 11 to 18 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Yeast Cat His tag   1 mg Log in to see 60 to 71 Days
Yeast REACT_Pelodiscus sinensis japonicus His tag   1 mg Log in to see 60 to 71 Days

TYR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)
Rat (Rattus)

More Proteins for Tyrosinase  (TYR) Interaction Partners

Zebrafish Tyrosinase  (TYR) interaction partners

  1. Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.

Atlantic Salmon (Salmo salar) Tyrosinase  (TYR) interaction partners

  1. Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK (show SHPK Proteins)-1) is influenced by temperature, but not by virus infection or bacterin stimulation.

Human Tyrosinase  (TYR) interaction partners

  1. The effect of histidine mutations on the structural stability of human tyrosinase leading to albinism has been reported.

  2. Compound heterozygous mutations (c.832C>T and c.929_930insC) in the TYR gene may be responsible for partial clinical manifestations of oculocutaneous albinism

  3. Mutations in tyrosinase gene is associated with Oculocutaneous albinism type 1.

  4. tyrosinase as a potential GPR143 (show GPR143 Proteins) binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.

  5. Aberrant tyrosinase expression in an atypical fibroxanthoma

  6. Findings suggested that miR (show MLXIP Proteins)-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 (show PDIA3 Proteins) expression.

  7. Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage

  8. LEF-1 (show LEF1 Proteins) and MITF (show MITF Proteins) regulate tyrosinase gene transcription in vitro via binding to its promoter.

  9. Data show that mutant microphthalmia-associated transcription factor (MITF (show MITF Proteins)) with loss of localization signals (NLS (show ALDH1A2 Proteins)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.

  10. The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app (show APP Proteins). 60%) albinism patients.

Mouse (Murine) Tyrosinase  (TYR) interaction partners

  1. This study demonstrates the utility of CRISPR-Cas9 system in generating domain-specific in-frame deletions and helps gain further insights into structure-function of Tyr gene.

  2. These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.

  3. Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.

  4. STAP-2 (show STAP2 Proteins) colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.

  5. Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.

  6. Studied upregulation by Kaliziri extract of tyrosinase, TRP-1 (show TRPC1 Proteins), TRP-2 (show DCT Proteins) and MITF (show MITF Proteins) expression in murine B16 melanoma cells.

  7. The albino mutation of tyrosinase alters ocular angiogenic responsiveness.

  8. Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.

  9. activated by ascorbic acid in B16 melanoma via p38 MAPK (show MAPK14 Proteins) signaling and upregulation of melanogenic regulatory factors

  10. Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells

Guinea Pig Tyrosinase  (TYR) interaction partners

  1. the missense mutation (c.710A>G; p.Asp237Gly) in the TYR gene is associated with the albino phenotype in guinea pig

Rabbit Tyrosinase  (TYR) interaction partners

  1. we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1 (show TYRP1 Proteins)) and Tyrosinase (TYR), as well as genes with unknown functions.

Tyrosinase  (TYR) Protein Profile

Protein Summary

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Gene names and symbols associated with Tyrosinase  Proteins (TYR)

  • tyrosinase (tyr)
  • TYRosinase (tyr-5)
  • tyrosinase S homeolog (tyr.S)
  • tyrosinase (TYR)
  • tyrosinase (Celal_3121)
  • tyrosinase (Halhy_4121)
  • tyrosinase (Mesop_2736)
  • tyrosinase (LOC100136546)
  • tyrosinase (Tyr)
  • albino protein
  • C protein
  • CMM8 protein
  • LOC100136546 protein
  • OCA1A protein
  • OCAIA protein
  • sandy protein
  • SHEP3 protein
  • skc35 protein
  • tyr protein
  • TYRO protein
  • zgc:109705 protein

Protein level used designations for Tyrosinase  Proteins (TYR)

oca1 , sdy , tyra , hypothetical protein , tyrosinase (oculocutaneous albinism IA) , tyrosinase , monophenol monooxygenase , tyrosinase-like , LB24-AB , SK29-AB , oculocutaneous albinism IA , tumor rejection antigen AB , albino locus protein

30207 Danio rerio
189907 Caenorhabditis elegans
398715 Xenopus laevis
451473 Pan troglodytes
705792 Macaca mulatta
10145547 Cellulophaga algicola DSM 14237
10588308 Haliscomenobacter hydrossis DSM 1100
10826573 Mesorhizobium opportunistum WSM2075
100049427 Oryzias latipes
100125152 Xenopus (Silurana) tropicalis
100135825 Oncorhynchus mykiss
100136546 Salmo salar
100453479 Pongo abelii
100594055 Nomascus leucogenys
7299 Homo sapiens
22173 Mus musculus
308800 Rattus norvegicus
100713552 Cavia porcellus
403405 Canis lupus familiaris
751100 Felis catus
100008753 Oryctolagus cuniculus
407745 Sus scrofa
280951 Bos taurus
373971 Gallus gallus
780502 Ovis aries
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