anti-U2AF Homology Motif (UHM) Kinase 1 (UHMK1) Antibodies

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. Additionally we are shipping U2AF Homology Motif (UHM) Kinase 1 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UHMK1 127933 Q8TAS1
UHMK1 16589 P97343
UHMK1 246332 Q63285
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Top anti-U2AF Homology Motif (UHM) Kinase 1 Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Uhmk1 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Heart 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Mouse Un-conjugated FACS, WB 100 μL 11 to 14 Days
$522.50
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Dog Mouse Un-conjugated WB 100 μL 11 to 14 Days
$522.50
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Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
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Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western Blot at 1:1000 dilution Lane 1: human skeletal muscle lysate Lane 2: A-673 whole cell lysate Lysates/proteins at 20 ug per lane. Antibody is used in Western blot to detect KIST in K562 cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). 400 μL 2 to 3 Days
$515.63
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Human Goat Un-conjugated ELISA, WB   0.1 mg 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Lane 1: rat brain lysates Lane 2: human colon carcinoma lysates probed with Anti KIST/UHMK1 Polyclonal Antibody, Unconjugated (ABIN716516) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 47kD. Observed band size: 47kD. 100 μL 3 to 7 Days
$317.90
Details
Bat Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$507.83
Details

Top referenced anti-U2AF Homology Motif (UHM) Kinase 1 Antibodies

  1. Human Polyclonal UHMK1 Primary Antibody for IHC (p), ELISA - ABIN544233 : Petrovic, Costa, Lau, Raychaudhuri, Tyner: FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. in The Journal of biological chemistry 2007 (PubMed)

  2. Cow (Bovine) Polyclonal UHMK1 Primary Antibody for ELISA - ABIN4228447 : Nakamura, Okinaka, Hirano, Ono, Sugimoto, Shigeno, Fujisawa, Shinjo, Ohnishi: KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells. in Leukemia research 2008 (PubMed)

More Antibodies against U2AF Homology Motif (UHM) Kinase 1 Interaction Partners

Human U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells.

  2. genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians.

  3. Moreover, we showed that CATS and KIS antagonize the transactivation capacity of CALM/AF10.In summary, our results show that CATS interacts with and is a substrate for KIS, suggesting that KIS regulates CATS function

  4. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored.

  5. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens.

  6. KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors.

  7. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP.

  8. KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression

  9. Results show that KIS is a direct transcriptional target of FoxM1.

  10. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia

  11. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample.

  12. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines.

Mouse (Murine) U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines.

  2. disregulation of gene expression due to KIS inactivation affects specific brain functions.

  3. Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.

  4. Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.

  5. KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.

  6. Phosphorylation of p27Kip1 by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin phosphorylation in VSMCs

U2AF Homology Motif (UHM) Kinase 1 (UHMK1) Antigen Profile

Protein Summary

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with UHMK1

  • U2AF homology motif kinase 1 (UHMK1) antibody
  • U2AF homology motif (UHM) kinase 1 (uhmk1) antibody
  • U2AF homology motif (UHM) kinase 1 (UHMK1) antibody
  • U2AF homology motif (UHM) kinase 1 (Uhmk1) antibody
  • U2AF homology motif kinase 1 (Uhmk1) antibody
  • 4732477C12Rik antibody
  • 4930500M09Rik antibody
  • AA673513 antibody
  • AI449218 antibody
  • AU021979 antibody
  • KIS antibody
  • Kist antibody
  • P-CIP2 antibody
  • UHMK1 antibody
  • zgc:153241 antibody

Protein level used designations for UHMK1

U2AF homology motif (UHM) kinase 1 , kinase interacting stathmin , serine/threonine-protein kinase Kist , serine/threonine-protein kinase Kist-like , KIS protein kinase , PAM COOH-terminal interactor protein 2 , kinase interacting with leukemia-associated gene (stathmin) , U2AF homology motif kinase 1 , kinase interacting with stathmin , P-CIP2

GENE ID SPECIES
424369 Gallus gallus
469560 Pan troglodytes
720105 Macaca mulatta
767721 Danio rerio
100058796 Equus caballus
100408720 Callithrix jacchus
100585553 Nomascus leucogenys
100622137 Sus scrofa
127933 Homo sapiens
16589 Mus musculus
478986 Canis lupus familiaris
246332 Rattus norvegicus
538770 Bos taurus
100172072 Pongo abelii
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