anti-Ubiquilin 1 (UBQLN1) Antibodies

Human Ubiquilin 1 (UBQLN1) interaction partners

1. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities.

2. Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.

3. UBQLN1 variant was not associated with the risk of Alzheimer's disease.

4. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

5. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R.

6. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

7. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1.

8. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation

9. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

10. The results suggest that UBQ-8i polymorphism may contribute to Alzheimer's disease susceptibility, but does not synergize with APOEepsilon4 status to increase Alzheimer's disease risk.

11. These results suggest that the UBQ-8i polymorphism is associated with Alzheimer's disease risk.

12. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

13. High UBQLN1 expression is associated with low radiosensitivity in breast cancer.

14. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease

15. Human ubiquilin-1 overexpression in transgenic mice increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

16. The results demonstrate that in Alzheimer's disease hippocampus, ubiquilin-1 immunoreactivity increases in the neuronal nucleoplasm and is associated with region-specific neurofibrillary changes.

17. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

18. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain.

19. data suggest that ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage and thus may play a role in regulating gamma-secretase cleavage of various substrates.

20. Genetic variants in UBQLN1 are not commonly associated with amyotrophic lateral sclerosis

Mouse (Murine) Ubiquilin 1 (UBQLN1) interaction partners

1. Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery.

2. This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice.

3. Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 and AMPK.

4. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation

5. propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis

6. Ubqln protects mice from oxidative stress and ischemic stroke-caused neuronal injury through facilitating removal of damaged proteins

7. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

8. Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.

9. UBQLN1-transfected cells did not show increased starvation-induced cell death

10. Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells.