anti-Ubiquilin 1 (UBQLN1) Antibodies

UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 1 Kits (7) and Ubiquilin 1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBQLN1 29979 Q9UMX0
UBQLN1 56085 Q8R317
UBQLN1 114590 Q9JJP9
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Top anti-Ubiquilin 1 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with UBQLN1 antibody ABIN462260 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with UBQLN1 antibody ABIN462260 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: 293T 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed A549, using Ubiquilin-1, antibody at 1:200 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), IP, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with UBQLN1 antibody ABIN396937 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Prostate (formalin-fixed, paraffin-embedded) stained with UBQLN1 antibody ABIN396937 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC (p), WB Antibody is used in Western blot to detect Dsk2 in HeLa cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Antibody is used in Western blot to detect Dsk2 in HeLa cell lysate. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescent analysis of Hela cells, using Ubiquilin1 Antibody . Antibody was diluted at 1:100 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor 554 (red) conjugated Phalloidin (red). Western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the Ubiquilin1 antibody detected the Ubiquilin1 protein (arrow). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of pre-incubated with and without blocking peptide in Jurkat cell line lysate Western blot analysis of Ubiquilin1 using Ubiquilin1 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Ubiquilin1 gene (Lane 2). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in SH-SY5Y,U87-MG cell line lysates (35ug/lane).This demonstrates the PLIC1 antibody detected the PLIC1 protein (arrow). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 to 3 Days
$515.63
Details

Top referenced anti-Ubiquilin 1 Antibodies

  1. Human Polyclonal Ubiquilin 1 Primary Antibody for IHC (p), ELISA - ABIN542760 : Kleijnen, Shih, Zhou, Kumar, Soccio, Kedersha, Gill, Howley: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. in Molecular cell 2000 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Ubiquilin 1 Primary Antibody for ELISA, WB - ABIN545161 : Mah, Perry, Smith, Monteiro: Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. in The Journal of cell biology 2000 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Ubiquilin 1 Primary Antibody for IHC (p), ELISA - ABIN545162 : Gao, Tu, Shi, Lee, Asanaka, Hwang, Lai: Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. in Journal of virology 2003 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Ubiquilin 1 Interaction Partners

Human Ubiquilin 1 (UBQLN1) interaction partners

  1. finding suggests that there is a dynamic interplay between RRM2 and the NS5B-hPLIC1 complex that has an important function in HCV replication. Together, these results identify a role of host RRM2 in viral RNA replication.

  2. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities.

  3. Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.

  4. UBQLN1 variant was not associated with the risk of Alzheimer's disease.

  5. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

  6. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R.

  7. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  8. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1.

  9. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation

  10. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

  11. The results suggest that UBQ-8i polymorphism may contribute to Alzheimer's disease susceptibility, but does not synergize with APOEepsilon4 status to increase Alzheimer's disease risk.

  12. These results suggest that the UBQ-8i polymorphism is associated with Alzheimer's disease risk.

  13. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

  14. High UBQLN1 expression is associated with low radiosensitivity in breast cancer.

  15. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease

  16. Human ubiquilin-1 overexpression in transgenic mice increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

  17. The results demonstrate that in Alzheimer's disease hippocampus, ubiquilin-1 immunoreactivity increases in the neuronal nucleoplasm and is associated with region-specific neurofibrillary changes.

  18. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

  19. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain.

  20. data suggest that ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage and thus may play a role in regulating gamma-secretase cleavage of various substrates.

Mouse (Murine) Ubiquilin 1 (UBQLN1) interaction partners

  1. The results of this study revealed that hypoxia-ischemic decreased the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy.

  2. Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery.

  3. This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice.

  4. Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 and AMPK.

  5. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation

  6. propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis

  7. Ubqln protects mice from oxidative stress and ischemic stroke-caused neuronal injury through facilitating removal of damaged proteins

  8. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

  9. Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.

  10. UBQLN1-transfected cells did not show increased starvation-induced cell death

  11. Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells.

Ubiquilin 1 (UBQLN1) Antigen Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Ubiquilin 1 (UBQLN1) Antibodies

  • ubiquilin 1 (UBQLN1) antibody
  • ubiquilin 1 (Ubqln1) antibody
  • 1110046H03Rik antibody
  • 1810030E05Rik antibody
  • AU019746 antibody
  • C77538 antibody
  • D13Ertd372e antibody
  • Da41 antibody
  • Dsk2 antibody
  • Plic-1 antibody
  • Plic1 antibody
  • UBQLN1 antibody
  • UBQN antibody
  • Xdrp1 antibody

Protein level used designations for anti-Ubiquilin 1 (UBQLN1) Antibodies

ubiquilin-1 , ubiquilin 1 , ubiquilin-1-like , hPLIC-1 , protein linking IAP with cytoskeleton 1 , PLIC-1

GENE ID SPECIES
100174657 Pongo abelii
100302096 Ovis aries
100394790 Callithrix jacchus
29979 Homo sapiens
282392 Bos taurus
56085 Mus musculus
114590 Rattus norvegicus
427454 Gallus gallus
476312 Canis lupus familiaris
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