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Ubiquilin 1 Products

(Ubiquilin 1 (UBQLN1))
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Ubiquilin 1 Categories

Ubiquilin 1 Antibodies

High quality antibodies with extensive validation data.

Ubiquilin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Ubiquilin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Ubiquilin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), IF
Validations
  • (3)
  • (3)
Cat. No. ABIN388966
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Monkey, Rabbit, Sheep
Application WB, IHC, IHC (p)
Validations
  • (4)
Cat. No. ABIN6741620
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF
Validations
  • (5)
Cat. No. ABIN3029415
Quantity 0.4 mL
Datasheet Datasheet

Recommended Ubiquilin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971031
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6208313
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1164827
Quantity 96 tests
Datasheet Datasheet

Recommended Ubiquilin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324458
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2734885
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2734886
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our Ubiquilin 1 products

Chen, Wang, Jiang, Zheng, Justice, Wang, Ran, Li, Huo, Zhang, Li, Lu, Wang, Zheng, Long, Yang: "APP modulates KCC2 expression and function in hippocampal GABAergic inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Sun, Liu, Yuan, Guo, Xie, Du, Lin, Xu, Liu, Wang, Yuan, Chen: "MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1." in: International journal of cancer. Journal international du cancer, Vol. 136, Issue 5, pp. 1003-12, (2014) (PubMed).

Bieniek, Murray, Rutherford, Castanedes-Casey, DeJesus-Hernandez, Liesinger, Baker, Boylan, Rademakers, Dickson: "Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion." in: Acta neuropathologica, Vol. 125, Issue 2, pp. 289-302, (2013) (PubMed).

Bao, Zhang, Zheng, Xu, Yan: "UBQLN1 interacts with SPEM1 and participates in spermiogenesis." in: Molecular and cellular endocrinology, Vol. 327, Issue 1-2, pp. 89-97, (2010) (PubMed).

Sick, Boukhari, Deramaudt, Rondé, Bucher, André, Gies, Takeda: "Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway." in: Glia, Vol. 59, Issue 2, pp. 308-19, (2010) (PubMed).

Massey, Mah, Ford, Miller, Liang, Doong, Monteiro: "Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins." in: Journal of Alzheimer's disease : JAD, Vol. 6, Issue 1, pp. 79-92, (2004) (PubMed).

Gao, Tu, Shi, Lee, Asanaka, Hwang, Lai: "Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase." in: Journal of virology, Vol. 77, Issue 7, pp. 4149-59, (2003) (PubMed).

Kleijnen, Shih, Zhou, Kumar, Soccio, Kedersha, Gill, Howley: "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome." in: Molecular cell, Vol. 6, Issue 2, pp. 409-19, (2000) (PubMed).

Mah, Perry, Smith, Monteiro: "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 847-62, (2000) (PubMed).

Synonyms and alternative names related to Ubiquilin 1

ubiquilin 1 (UBQLN1), ubiquilin 1 (Ubqln1), 1110046H03Rik, 1810030E05Rik, AU019746, C77538, D13Ertd372e, DA41, Da41, DSK2, Dsk2, PLIC-1, Plic-1, Plic1, UBQLN1, UBQN, XDRP1, Xdrp1

Protein level used designations for Ubiquilin 1

  • ubiquilin-1
  • ubiquilin 1
  • ubiquilin-1-like
  • hPLIC-1
  • protein linking IAP with cytoskeleton 1
  • PLIC-1
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