Ubiquilin 1 Proteins (UBQLN1)

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

• ubiquilin 1 (UBQLN1)
• ubiquilin 1 (Ubqln1)

• 1110046H03Rik protein
• 1810030E05Rik protein
• AU019746 protein
• C77538 protein
• D13Ertd372e protein
• Show all synonym aliases
• Da41 protein
• Dsk2 protein
• Plic-1 protein
• Plic1 protein
• UBQLN1 protein
• UBQN protein
• Xdrp1 protein

ubiquilin-1 , ubiquilin 1 , ubiquilin-1-like , hPLIC-1 , protein linking IAP with cytoskeleton 1 , PLIC-1