Ubiquilin 1 Proteins (UBQLN1)

Human Ubiquilin 1 (UBQLN1) interaction partners

1. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2 (show UBQLN2 Proteins); therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities.

2. Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.

3. UBQLN1 variant was not associated with the risk of Alzheimer's disease.

4. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

5. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R (show IGF1R Proteins).

6. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

7. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 (show HSF1 Proteins) and UBQLN1.

8. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

9. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

10. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

Mouse (Murine) Ubiquilin 1 (UBQLN1) interaction partners

1. Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery.

2. This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice.

3. Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 (show SIRT1 Proteins) and AMPK (show PRKAA1 Proteins).

4. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

5. propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis

6. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions

7. Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.

8. UBQLN1-transfected cells did not show increased starvation-induced cell death

9. Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2 (show PSEN2 Proteins)) protein levels in cells.