Ubiquilin 1 Proteins (UBQLN1)

UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 1 Antibodies (95) and Ubiquilin 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBQLN1 29979 Q9UMX0
Mouse UBQLN1 UBQLN1 56085 Q8R317
UBQLN1 114590 Q9JJP9
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Top Ubiquilin 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,670.33
Details

UBQLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

More Proteins for Ubiquilin 1 (UBQLN1) Interaction Partners

Human Ubiquilin 1 (UBQLN1) interaction partners

  1. UBQLN1 variant was not associated with the risk of Alzheimer's disease.

  2. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

  3. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R (show IGF1R Proteins).

  4. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  5. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 (show HSF1 Proteins) and UBQLN1.

  6. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  7. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

  8. Chloroquine derivative D5 downregulates presenilin expression via the inhibition of ubiquilin 1 expression.

  9. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

  10. High UBQLN1 expression is associated with low radiosensitivity in breast cancer.

Mouse (Murine) Ubiquilin 1 (UBQLN1) interaction partners

  1. This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice.

  2. Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 (show SIRT1 Proteins) and AMPK (show PRKAA1 Proteins).

  3. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  4. propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis

  5. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions

  6. Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.

  7. UBQLN1-transfected cells did not show increased starvation-induced cell death

  8. Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2 (show PSEN2 Proteins)) protein levels in cells.

Ubiquilin 1 (UBQLN1) Protein Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Ubiquilin 1 Proteins (UBQLN1)

  • ubiquilin 1 (UBQLN1)
  • ubiquilin 1 (Ubqln1)
  • 1110046H03Rik protein
  • 1810030E05Rik protein
  • AU019746 protein
  • C77538 protein
  • D13Ertd372e protein
  • Da41 protein
  • Dsk2 protein
  • Plic-1 protein
  • Plic1 protein
  • UBQLN1 protein
  • UBQN protein
  • Xdrp1 protein

Protein level used designations for Ubiquilin 1 Proteins (UBQLN1)

ubiquilin-1 , ubiquilin 1 , ubiquilin-1-like , hPLIC-1 , protein linking IAP with cytoskeleton 1 , PLIC-1

GENE ID SPECIES
100174657 Pongo abelii
100302096 Ovis aries
100394790 Callithrix jacchus
29979 Homo sapiens
282392 Bos taurus
56085 Mus musculus
114590 Rattus norvegicus
427454 Gallus gallus
476312 Canis lupus familiaris
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