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UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 1 Antibodies (101) and Ubiquilin 1 Kits (8) and many more products for this protein.
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Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.
UBQLN1 variant was not associated with the risk of Alzheimer's disease.
The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.
Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R (show IGF1R Proteins).
Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.
The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 (show HSF1 Proteins) and UBQLN1.
Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation
The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.
found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1
High UBQLN1 expression is associated with low radiosensitivity in breast cancer.
Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery.
This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice.
Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 (show SIRT1 Proteins) and AMPK (show PRKAA1 Proteins).
propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis
results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions
Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.
UBQLN1-transfected cells did not show increased starvation-induced cell death
Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2 (show PSEN2 Proteins)) protein levels in cells.
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
, ubiquilin 1
, protein linking IAP with cytoskeleton 1