Ubiquilin 1 Proteins (UBQLN1)

UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 1 Antibodies (107) and Ubiquilin 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBQLN1 29979 Q9UMX0
Mouse UBQLN1 UBQLN1 56085 Q8R317
UBQLN1 114590 Q9JJP9
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Top Ubiquilin 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,670.33
Details

UBQLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

More Proteins for Ubiquilin 1 (UBQLN1) Interaction Partners

Human Ubiquilin 1 (UBQLN1) interaction partners

  1. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities.

  2. Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.

  3. UBQLN1 variant was not associated with the risk of Alzheimer's disease.

  4. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

  5. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R.

  6. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  7. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1.

  8. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation

  9. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

  10. The results suggest that UBQ-8i polymorphism may contribute to Alzheimer's disease susceptibility, but does not synergize with APOEepsilon4 status to increase Alzheimer's disease risk.

  11. These results suggest that the UBQ-8i polymorphism is associated with Alzheimer's disease risk.

  12. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

  13. High UBQLN1 expression is associated with low radiosensitivity in breast cancer.

  14. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease

  15. Human ubiquilin-1 overexpression in transgenic mice increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

  16. The results demonstrate that in Alzheimer's disease hippocampus, ubiquilin-1 immunoreactivity increases in the neuronal nucleoplasm and is associated with region-specific neurofibrillary changes.

  17. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

  18. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain.

  19. data suggest that ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage and thus may play a role in regulating gamma-secretase cleavage of various substrates.

  20. Genetic variants in UBQLN1 are not commonly associated with amyotrophic lateral sclerosis

Ubiquilin 1 (UBQLN1) Protein Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Ubiquilin 1 Proteins (UBQLN1)

  • ubiquilin 1 (UBQLN1)
  • ubiquilin 1 (Ubqln1)
  • 1110046H03Rik protein
  • 1810030E05Rik protein
  • AU019746 protein
  • C77538 protein
  • D13Ertd372e protein
  • Da41 protein
  • Dsk2 protein
  • Plic-1 protein
  • Plic1 protein
  • UBQLN1 protein
  • UBQN protein
  • Xdrp1 protein

Protein level used designations for Ubiquilin 1 Proteins (UBQLN1)

ubiquilin-1 , ubiquilin 1 , ubiquilin-1-like , hPLIC-1 , protein linking IAP with cytoskeleton 1 , PLIC-1

GENE ID SPECIES
100174657 Pongo abelii
100302096 Ovis aries
100394790 Callithrix jacchus
29979 Homo sapiens
282392 Bos taurus
56085 Mus musculus
114590 Rattus norvegicus
427454 Gallus gallus
476312 Canis lupus familiaris
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