Ubiquilin 2 (UBQLN2) ELISA Kits

UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 2 Antibodies (71) and Ubiquilin 2 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
UBQLN2 29978 Q9UHD9
UBQLN2 54609 Q9QZM0
Anti-Rat UBQLN2 UBQLN2 317396  
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Top Ubiquilin 2 ELISA Kits at antibodies-online.com

Showing 2 out of 13 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.64 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Mouse < 0.078 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$589.86
Details

More ELISA Kits for Ubiquilin 2 Interaction Partners

Human Ubiquilin 2 (UBQLN2) interaction partners

  1. our data highlight a safeguarding function of the MTM1-UBQLN2 complex that ensures cytoskeletal integrity to avoid proteotoxic aggregate formation

  2. These results reveal a previously unrecognized role for UBQLN2 in regulating the early stages of liquid-liquid phase separation by directly modulating the fluidity of protein-RNA complexes and the dynamics of SG formation.

  3. polyQ-expanded Htt-N552 and Atx-3 sequester endogenous Ub adaptors, human RAD23 homolog B (hHR23B) and ubiquilin (UBQLN)-2, into inclusions. This sequestration effect is dependent on the UBA domains of Ub adaptors and the conjugated Ub of the aggregated proteins.

  4. UBQLN2 liquid-liquid phase separation enables its recruitment to stress granules, where its interactions with ubiquitinated substrates reverse LLPS to enable shuttling of clients out of stress granules.

  5. Authors propose that ALS-associated mutations in UBQLN2 disrupt folding and that both aggregated species and soluble oligomers instigate neuron autonomous toxicity through interference with Ub homeostasis.

  6. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities.

  7. Its PXX domain missense mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis.

  8. Its mutation is a cause of amyotrophic lateral sclerosis in New Zealand.

  9. The structures of proteasome substrate receptor complexes with the shuttle factors that deliver ubiquitinated proteins to proteasomes have been solved, namely human Rpn13 complexed with PLIC2 and Saccharomyces cerevisiae Rpn1 with Rad23.

  10. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  11. We analyzed mutations in the UBQLN2 gene in a Chinese cohort with sporadic ALS (sALS). A novel missense mutation was detected in one sALS patient. The p.M392V mutation substitutes a highly conserved residue, has not been reported in the population databases, and previously, at the same residue, a missense mutation p.M392I was detected in two Turkey ALS patients and was considered to be pathogenic.

  12. Frontotemporal dementia -linked mutations in gene ubiquilin 2 encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  13. excess UBQLN2 is toxic rather than protective to neurons and that uncontrolled enhancement of UBQLN2 function is involved in UBQLN2 pathogenesis

  14. Ubiquilin-2 immunostaining - a new marker as a diagnostic supplement in urine cytology?

  15. UBQLN2 is specifically expressed in the urine of urothelial carcinoma patients.

  16. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3

  17. These findings provide a molecular basis for the development of ALS/FTD-associated proteinopathy and establish novel therapeutic targets for ALS.

  18. Mutations in UBQLN2 gene cause dominant inheritance of amyotrophic lateral sclerosis due to Defective Proteasome Delivery.

  19. UBQLN2 may be a new molecular target for chemotherapeutics and a useful clinicopathological marker in human osteosarcoma.

  20. ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1

Mouse (Murine) Ubiquilin 2 (UBQLN2) interaction partners

  1. Results have shown that the two P497S and P506T mutant UBQLN2 Tg mouse lines recapitulate the central features of ALS with frontotemporal dementia (ALS-FTD) found in humans and indicate that these mutant UBQLN2 mice with end stage of disease display a reduction of TDP-43 staining in the nucleus with concomitant formation of cytoplasmic ubiquitin+ inclusions in spinal motor neurons.

  2. UBQLN2 most evidently bound to HSP70-type chaperones, UBQLN1 and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice.

  3. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3

  4. UBQLN2 dysregulation in neurons can drive NF-kappaB activation and cytosolic TDP-43 aggregation.

  5. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.

  6. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions

  7. UBQLN2-transfected cells did not show increased starvation-induced cell death.

Ubiquilin 2 (UBQLN2) Antigen Profile

Antigen Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Gene names and symbols associated with Ubiquilin 2 (UBQLN2) ELISA Kits

  • ubiquilin 2 (UBQLN2) antibody
  • ubiquilin 2 (Ubqln2) antibody
  • ALS15 antibody
  • Chap1 antibody
  • Dsk2 antibody
  • HRIHFB2157 antibody
  • N4BP4 antibody
  • Plic-2 antibody
  • Plic2 antibody
  • RGD1563566 antibody
  • UBQLN2 antibody

Protein level used designations for Ubiquilin 2 (UBQLN2) ELISA Kits

Nedd4 binding protein 4 , protein linking IAP with cytoskeleton 2 , ubiquilin-2 , ubiquitin-like product Chap1/Dsk2 , Ubiquitin-related protein , ubiquilin 2

GENE ID SPECIES
29978 Homo sapiens
54609 Mus musculus
317396 Rattus norvegicus
419078 Gallus gallus
491909 Canis lupus familiaris
539529 Bos taurus
743819 Pan troglodytes
100347089 Oryctolagus cuniculus
100724333 Cavia porcellus
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