anti-Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Antibodies

UBASH3A encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Additionally we are shipping Ubiquitin Associated and SH3 Domain Containing, A Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBASH3A 53347 P57075
UBASH3A 328795 Q3V3E1
UBASH3A 309666  
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Top anti-Ubiquitin Associated and SH3 Domain Containing, A Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBASH3A Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Placenta 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA, IHC ABIN190877 (2.5µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg 6 to 7 Days
$429.84
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Human Goat Un-conjugated ELISA, IHC, WB   100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p) Human Spleen (formalin-fixed, paraffin-embedded) stained with UBASH3A antibody ABIN290205 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-UBASH3A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$537.17
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Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from LOVO cells using UBASH3A antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275614 staining  LOVO cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Goat Un-conjugated EIA, IHC (p), WB AP32140PU-N STS2 / TULA antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. AP32140PU-N STS2 / TULA antibody staining of Human Spleen lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg 6 to 8 Days
$445.50
Details

Top referenced anti-Ubiquitin Associated and SH3 Domain Containing, A Antibodies

  1. Dog (Canine) Polyclonal UBASH3A Primary Antibody for IHC (p), ELISA - ABIN547837 : Kowanetz, Crosetto, Haglund, Schmidt, Heldin, Dikic: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Ubiquitin Associated and SH3 Domain Containing, A Interaction Partners

Human Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) interaction partners

  1. this reduction in UBASH3A, as a consequence of the minor allele at rs1893592, resulted in increased secretion of IL-2, a key cytokine that is required for T-cell activation and function but is deficient in some type 1 diabetes (T1D). Our study provides new mechanistic insights into how rs1893592 affects T1D and autoimmunity and how interactions between multiple T1D-associated, noncoding variants influence the disease risk

  2. UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population.

  3. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation.

  4. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus.

  5. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease.

  6. these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors.

  7. Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction.

  8. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases.

  9. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype

  10. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells.

  11. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

  12. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin

  13. TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors

  14. Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events.

  15. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk

Mouse (Murine) Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) interaction partners

  1. Bone marrow-derived dendritic cells (BMDCs) lacking ubiquitin associated and SH3 domain containing A (Sts-2) expression have an enhanced ability to inhibit Candida albicans growth and contribute significantly to the resistance of Sts-/- mice. Within BMDCs, the Sts phosphatases negatively regulate the activation of select pathways downstream of the key fungal pathogen pattern recognition receptor Dectin-1.

  2. STS-2 suppresses development of collagen-induced arthritis.

  3. Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.

  4. Sts-1 and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.

  5. Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.

  6. The lack of TULA facilitates T-cell responses to TCR/CD3 stimulation, thus exacerbating T-cell-dependent inflammation.

  7. Skeletal analysis of mice that do not express TULA or TULA-2 proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.

  8. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.

  9. Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 despite the strong structural homology.

  10. the crystal structure of Sts-2(PGM) in the phosphorylated active form and bound to VO(3)

  11. The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.

Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Antigen Profile

Protein Summary

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with UBASH3A

  • ubiquitin associated and SH3 domain containing A (UBASH3A) antibody
  • ubiquitin associated and SH3 domain containing, A (Ubash3a) antibody
  • 5830413C03Rik antibody
  • C330001M22 antibody
  • CLIP4 antibody
  • Sts-2 antibody
  • TULA antibody
  • TULA-1 antibody
  • UBASH3A antibody

Protein level used designations for UBASH3A

ubiquitin associated and SH3 domain containing, A , T-cell ubiquitin ligand 1 , T-cell ubiquitin ligand protein , cbl-interacting protein 4 , suppressor of T-cell receptor signaling 2 , ubiquitin-associated and SH3 domain-containing protein A

GENE ID SPECIES
418535 Gallus gallus
474125 Pan troglodytes
53347 Homo sapiens
487779 Canis lupus familiaris
514555 Bos taurus
328795 Mus musculus
309666 Rattus norvegicus
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