anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Antibodies

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. Additionally we are shipping UBR1 Kits (11) and UBR1 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBR1 197131 Q8IWV7
UBR1 22222 O70481
UBR1 499877  
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Top anti-UBR1 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBR1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2/Jurkat cells, using UBR1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated IHC, WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275098 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Mouse Rabbit Un-conjugated WB Western blot analysis in mouse liver tissue lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: UBR1 Antibody  - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-UBR1 Antibodies

  1. Mouse (Murine) Polyclonal UBR1 Primary Antibody for WB - ABIN1881972 : Alkhouri, Kaplan, Kay, Shealy, Crowe, Bauhuber, Zenker: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing. in World journal of gastroenterology : WJG 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal UBR1 Primary Antibody for ELISA, WB - ABIN566929 : Ozawa, Nakao, Kurihara, Shimazaki, Shimmura, Ishida, Yoshimura, Tsubota, Okano: Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. in The Journal of biological chemistry 2008 (PubMed)

  3. Cow (Bovine) Polyclonal UBR1 Primary Antibody for WB - ABIN2781277 : Yamaguchi, Moritani, Tanahashi, Osabe, Nomura, Fujita, Keshavarz, Kunika, Nakamura, Yoshikawa, Ichiishi, Shiota, Yasui, Inoue, Itakura: Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population. in BMC medical genetics 2008 (PubMed)

More Antibodies against UBR1 Interaction Partners

Caenorhabditis elegans (C. elegans) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. results raise an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling

  2. show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28

Human Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. UBR1 mutations of single or multi-exon deletions or duplications account for a substantial proportion of Johanson-Blizzard syndrome.

  2. The frequency of any non-synonymous or synonymous variants was not different between the patients with chronic pancreatitis and controls

  3. Reduced UBR1 expression affects MGMT turnover and DNA repair in the smokers lungs.

  4. For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD.

  5. Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.

  6. Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.

  7. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome.

  8. Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1

  9. Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.

  10. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.

  11. Thus we propose that autoISGylation of EFP negatively regulates its ISG15 E3 ligase activity for 14-3-3sigma.

  12. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity.

  13. Thiazolidinediones modulate the expression of beta catenin and other cell cycle proteins by targeting UBR1 independently of PPARG.

  14. E3 ubiquitin ligase is an essential downstream component of the RAS signal transduction pathway.

  15. study reports on two apparently unrelated girls with Johanson-Blizzard syndrome, in both children caused by a homozygous IVS26+5G>A mutation in the UBR1 gene

  16. Case Report: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. involved in learning and memory; behavioral characterizations of UBR1 knockout mice

  2. UBR1-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

  3. TLX1/HOX11 overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy

  4. A STAT3-dependent E3 ubiquitin ligase, Ubr1, was responsible for rhodopsin degradation and was up-regulated in the inflamed SOCS3-deficient retinas.

UBR1 Antigen Profile

Protein Summary

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Gene names and symbols associated with UBR1

  • Ubr1 ubiquitin ligase (Ubr1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (ubr1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (UBR1) antibody
  • E3 ubiquitin-protein ligase ubr-1 (ubr-1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (Ubr1) antibody
  • AI504731 antibody
  • Dmel\\CG9086 antibody
  • JBS antibody
  • RGD1562326 antibody
  • UBR1 antibody

Protein level used designations for UBR1

CG9086-PA , CG9086-PB , ubiquitin protein ligase E3 component n-recognin 1 , E3 ubiquitin-protein ligase UBR1 , E3a ligase , N-recognin-1 , ubiquitin ligase E3 alpha-I , ubiquitin-protein ligase E3-alpha , ubiquitin-protein ligase E3-alpha-1 , ubiquitin-protein ligase E3-alpha-I , E3 alpha , ubiquitin-protein ligase e3 componen n-recognin

GENE ID SPECIES
32687 Drosophila melanogaster
568531 Danio rerio
100010751 Monodelphis domestica
100056497 Equus caballus
100511299 Sus scrofa
100558444 Anolis carolinensis
171953 Caenorhabditis elegans
197131 Homo sapiens
22222 Mus musculus
487521 Canis lupus familiaris
522464 Bos taurus
499877 Rattus norvegicus
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