anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Antibodies

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. Additionally we are shipping UBR1 Kits (12) and UBR1 Proteins (2) and many more products for this protein.

Gene Name	GeneID	UniProt
UBR1	197131	Q8IWV7
UBR1	22222	O70481
UBR1	499877

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Top anti-UBR1 Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2781277	Cow	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN1534872	Human	Rabbit	Un-conjugated	ELISA, WB	100 μg	Log in to see	2 to 3 Days	$302.50	Details
ABIN3198366	Human	Rabbit	Un-conjugated	IHC, WB	200 μL	Log in to see	13 to 14 Days	$487.50	Details
ABIN468876	Bat	Rabbit	Un-conjugated	WB	50 μg	Log in to see	7 to 9 Days	$551.83	Details
ABIN393613	Human	Mouse	Un-conjugated	ELISA, WB	100 μg	Log in to see	8 to 11 Days	$461.00	Details
ABIN5534909	Mouse	Rabbit	Un-conjugated	WB	400 μL	Log in to see	2 to 3 Days	$515.63	Details
ABIN3187405	Human	Rabbit	Un-conjugated	ELISA, IHC, WB	100 μL	Log in to see	16 Days	$181.73	Details
ABIN4364014	Human	Rabbit	Un-conjugated	ICC, IF, IHC, IHC (p)	0.1 mL	Log in to see	10 to 13 Days	$491.63	Details
ABIN1457850	Human	Rabbit	Un-conjugated	ELISA, WB	100 μg	Log in to see	2 to 3 Days	$302.50	Details
ABIN566929	Human	Mouse	Un-conjugated	ELISA, WB	100 μg	Log in to see	11 to 12 Days	$440.00	Details

UBR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes	Applications	Host	Clonality	Conjugate
Human	, , , ,	,	,	, , , , ,
Mouse (Murine)	,			, , , , , , , ,
Rat (Rattus)	,			, , , ,

More product categories related to UBR1 Antibody

Top referenced anti-UBR1 Antibodies

Mouse (Murine) Polyclonal UBR1 Primary Antibody for WB - ABIN1881972 : Alkhouri, Kaplan, Kay, Shealy, Crowe, Bauhuber, Zenker: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing. in World journal of gastroenterology : WJG 2008 (PubMed)
Show all 2 Pubmed References
Human Monoclonal UBR1 Primary Antibody for ELISA, WB - ABIN566929 : Ozawa, Nakao, Kurihara, Shimazaki, Shimmura, Ishida, Yoshimura, Tsubota, Okano: Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. in The Journal of biological chemistry 2008 (PubMed)
Cow (Bovine) Polyclonal UBR1 Primary Antibody for WB - ABIN2781277 : Yamaguchi, Moritani, Tanahashi, Osabe, Nomura, Fujita, Keshavarz, Kunika, Nakamura, Yoshikawa, Ichiishi, Shiota, Yasui, Inoue, Itakura: Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population. in BMC medical genetics 2008 (PubMed)

More Antibodies against UBR1 Interaction Partners

Caenorhabditis elegans (C. elegans) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

results raise an intriguing possibility that UBR proteins regulate glutamate (show GRIN2A Antibodies) metabolism, which is critical for neuronal development and signaling
show that CED-3 caspase (show CASP3 Antibodies) and the E3 ubiquitin ligase (show MUL1 Antibodies) UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28

Human Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

UBR1 mutations of single or multi-exon deletions or duplications account for a substantial proportion of Johanson-Blizzard syndrome.
Reduced UBR1 expression affects MGMT (show MGMT Antibodies) turnover and DNA repair in the smokers lungs.
For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD.
Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.
Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.
Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome.
Ubc2 (show ube2a Antibodies)/Rad6 ser (show SIGLEC1 Antibodies)(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1
Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.
Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.
Thus we propose that autoISGylation of EFP (show TRIM25 Antibodies) negatively regulates its ISG15 (show ISG15 Antibodies) E3 ligase activity for 14-3-3sigma.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

involved in learning and memory; behavioral characterizations of UBR1 knockout mice
UBR1-/-UBR2 (show UBR2 Antibodies)-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.
TLX1/HOX11 (show TLX1 Antibodies) overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy
A STAT3 (show STAT3 Antibodies)-dependent E3 ubiquitin ligase (show MUL1 Antibodies), Ubr1, was responsible for rhodopsin (show RHO Antibodies) degradation and was up-regulated in the inflamed SOCS3 (show SOCS3 Antibodies)-deficient retinas.

UBR1 Antigen Profile

Protein Summary

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Gene names and symbols associated with UBR1

Ubr1 ubiquitin ligase (Ubr1) antibody
ubiquitin protein ligase E3 component n-recognin 1 (ubr1) antibody
ubiquitin protein ligase E3 component n-recognin 1 (UBR1) antibody
E3 ubiquitin-protein ligase ubr-1 (ubr-1) antibody
ubiquitin protein ligase E3 component n-recognin 1 (Ubr1) antibody

AI504731 antibody
Dmel\\CG9086 antibody
JBS antibody
RGD1562326 antibody
UBR1 antibody

Protein level used designations for UBR1

CG9086-PA , CG9086-PB , ubiquitin protein ligase E3 component n-recognin 1 , E3 ubiquitin-protein ligase UBR1 , E3a ligase , N-recognin-1 , ubiquitin ligase E3 alpha-I , ubiquitin-protein ligase E3-alpha , ubiquitin-protein ligase E3-alpha-1 , ubiquitin-protein ligase E3-alpha-I , E3 alpha , ubiquitin-protein ligase e3 componen n-recognin

GENE ID	SPECIES
32687	Drosophila melanogaster
568531	Danio rerio
100010751	Monodelphis domestica
100056497	Equus caballus
100511299	Sus scrofa
100558444	Anolis carolinensis
171953	Caenorhabditis elegans
197131	Homo sapiens
22222	Mus musculus
487521	Canis lupus familiaris
522464	Bos taurus
499877	Rattus norvegicus

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Fax:	+1 888 205 9894 (Toll-free)
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Show all anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Antibodies with Pubmed References