Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) ELISA Kits

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. Additionally we are shipping UBR1 Antibodies (57) and UBR1 Proteins (2) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
UBR1 197131 Q8IWV7
UBR1 22222 O70481
Anti-Rat UBR1 UBR1 499877  
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Top UBR1 ELISA Kits at antibodies-online.com

Showing 3 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.055 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
$810.53
Details
Human < 0.055 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$966.52
Details
Mouse
  96 Tests 11 to 18 Days
$618.29
Details

More ELISA Kits for UBR1 Interaction Partners

Caenorhabditis elegans (C. elegans) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. results raise an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling

  2. show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28

Human Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. UBR1 mutations of single or multi-exon deletions or duplications account for a substantial proportion of Johanson-Blizzard syndrome.

  2. The frequency of any non-synonymous or synonymous variants was not different between the patients with chronic pancreatitis and controls

  3. Reduced UBR1 expression affects MGMT turnover and DNA repair in the smokers lungs.

  4. For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD.

  5. Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.

  6. Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.

  7. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome.

  8. Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1

  9. Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.

  10. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.

  11. Thus we propose that autoISGylation of EFP negatively regulates its ISG15 E3 ligase activity for 14-3-3sigma.

  12. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity.

  13. Thiazolidinediones modulate the expression of beta catenin and other cell cycle proteins by targeting UBR1 independently of PPARG.

  14. E3 ubiquitin ligase is an essential downstream component of the RAS signal transduction pathway.

  15. study reports on two apparently unrelated girls with Johanson-Blizzard syndrome, in both children caused by a homozygous IVS26+5G>A mutation in the UBR1 gene

  16. Case Report: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. involved in learning and memory; behavioral characterizations of UBR1 knockout mice

  2. UBR1-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

  3. TLX1/HOX11 overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy

  4. A STAT3-dependent E3 ubiquitin ligase, Ubr1, was responsible for rhodopsin degradation and was up-regulated in the inflamed SOCS3-deficient retinas.

UBR1 Antigen Profile

Antigen Summary

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Gene names and symbols associated with UBR1

  • Ubr1 ubiquitin ligase (Ubr1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (ubr1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (UBR1) antibody
  • E3 ubiquitin-protein ligase ubr-1 (ubr-1) antibody
  • ubiquitin protein ligase E3 component n-recognin 1 (Ubr1) antibody
  • AI504731 antibody
  • Dmel\\CG9086 antibody
  • JBS antibody
  • RGD1562326 antibody
  • UBR1 antibody

Protein level used designations for UBR1

CG9086-PA , CG9086-PB , ubiquitin protein ligase E3 component n-recognin 1 , E3 ubiquitin-protein ligase UBR1 , E3a ligase , N-recognin-1 , ubiquitin ligase E3 alpha-I , ubiquitin-protein ligase E3-alpha , ubiquitin-protein ligase E3-alpha-1 , ubiquitin-protein ligase E3-alpha-I , E3 alpha , ubiquitin-protein ligase e3 componen n-recognin

GENE ID SPECIES
32687 Drosophila melanogaster
568531 Danio rerio
100010751 Monodelphis domestica
100056497 Equus caballus
100511299 Sus scrofa
100558444 Anolis carolinensis
171953 Caenorhabditis elegans
197131 Homo sapiens
22222 Mus musculus
487521 Canis lupus familiaris
522464 Bos taurus
499877 Rattus norvegicus
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