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USP15 encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. Additionally we are shipping USP15 Proteins (4) and many more products for this protein.
Showing 10 out of 91 products:
Human Monoclonal USP15 Primary Antibody for IF, ELISA - ABIN564282
Schweitzer, Bozko, Dubiel, Naumann: CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. in The EMBO journal 2007
Show all 9 Pubmed References
Human Polyclonal USP15 Primary Antibody for ICC, IF - ABIN258284
Isumi, Hirata, Saitoh, Miyakawa, Murakami, Kudoh, Doi, Ishibashi, Nakajima: Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice. in Biochemical and biophysical research communications 2011
Show all 2 Pubmed References
Human Polyclonal USP15 Primary Antibody for IHC (p), IHC - ABIN249918
Baker, Wang, Woollatt, White, Sutherland et al.: Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ... in Genomics 1999
Human Monoclonal USP15 Primary Antibody for IF, WB - ABIN2477039
Miyauchi, Kato, Tokunaga, Iwai: The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination. in The Journal of biological chemistry 2008
these data indicate that Nef and USP15 are vital in regulating degradation of viral and cellular proteins and thus HIV-1 replication, and specific degradation of viral, not cellular proteins.
We show that PRP31 (show PRPF31 Antibodies), a component of U4 snRNP (show LSM2 Antibodies), is modified with K63-linked ubiquitin chains by the PRP19 (show PRPF19 Antibodies) complex and deubiquitinated by USP15 and its substrate targeting factor SART3 (show SART3 Antibodies). USP15SART3 makes a complex with USP4 (show USP4 Antibodies) and this ternary complex serves as a platform to deubiquitinate PRP31 (show PRPF31 Antibodies) and PRP3 (show CLCA4 Antibodies)
TGF-b promotes the translation of USP15 through activation of mammalian target of rapamycin (show FRAP1 Antibodies) by the phosphoinositide 3-kinase/AKT (show AKT1 Antibodies) pathway. Upregulation of USP15 translation links the crosstalk between TGF-beta (show TGFB1 Antibodies) signaling and p53 (show TP53 Antibodies) stability, allowing this cytokine to have a critical role in cancer progression.
We concluded that USP15 attenuates IGF-I (show IGF1 Antibodies) signaling by antagonizing Nedd4 (show NEDD4 Antibodies)-induced IRS-2 (show IRS2 Antibodies) ubiquitination.
These results uncover a new regulatory mechanism that USP15 activates Nrf1 (show NFE2L1 Antibodies) against the beta-TrCP (show BTRC Antibodies) inhibition to maintain proteostasis.
Study identified USP15 as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 (show FOXP1 Antibodies) and KDM5B (show KDM5B Antibodies)).
crystal structures of SART3 (show SART3 Antibodies) in the apo (show C9orf3 Antibodies)-form and in complex with the DUSP (show DUSP5 Antibodies)-UBL domain of USP15 at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 (show SART3 Antibodies) contains 12 half-a-tetratricopeptide (HAT (show MGEA5 Antibodies)) repeats, organized into two subdomains, HAT (show MGEA5 Antibodies)-N and HAT (show MGEA5 Antibodies)-C. SART3 (show SART3 Antibodies) dimerizes through the concave surface of HAT (show MGEA5 Antibodies)-C, whereas the HAT (show MGEA5 Antibodies)-C convex surface binds USP15 in a novel bipartite mode.
SMURF2 (show SMURF2 Antibodies) is a critical target of USP15 in the TGF-beta (show TGFB1 Antibodies) signaling pathway.
our data demonstrate that USP15 acts as a negative regulator of RIG-I (show DDX58 Antibodies) signaling via DUB-dependent and independent mechanisms.
These data identify USP15 as an antagonist of Parkin (show PARK2 Antibodies) and suggest that USP15 inhibition could be a therapeutic strategy for PD cases caused by reduced Parkin (show PARK2 Antibodies) levels.
In hematopoietic cells and in resident brain cells, USP15 was coexpressed with, and functionally acted together with the E3 ubiquitin ligase (show MUL1 Antibodies) TRIM25 (show TRIM25 Antibodies) to positively regulate type I interferon (show IFNA Antibodies) responses and to promote pathogenesis during neuroinflammation.
T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma (show IFNG Antibodies), which promotes an immunosuppressive tumor microenvironment during MCA (show RSPH1 Antibodies)-induced primary tumorigenesis.
Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 (show USP4 Antibodies) gene.
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.
ubiquitin specific peptidase 15
, universal stress protein
, ubiquitin carboxyl-terminal hydrolase 15-like
, ubiquitin carboxyl-terminal hydrolase 15
, ubiquitin specific protease 15
, ubiquitous nuclear protein
, Deubiquitinating enzyme 15
, Ubiquitin thioesterase 15
, Ubiquitin-specific-processing protease 15
, deubiquitinating enzyme 15
, ubiquitin thioesterase 15
, ubiquitin-specific-processing protease 15
, ubiquitin thiolesterase 15
, granule cell antiserum positive 18
, deubiquitinating enzyme Ubp109
, ubiquitin carboxyl-terminal hydrolase of 109 kDa