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USP2 encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. Additionally we are shipping USP2 Antibodies (135) and many more products for this protein.
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This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
41 kDa ubiquitin-specific protease
, deubiquitinating enzyme 2
, ubiquitin carboxyl-terminal hydrolase 2
, ubiquitin specific protease 12
, ubiquitin specific protease 9
, ubiquitin thioesterase 2
, ubiquitin-specific-processing protease 2
, ubiquitin specific protease 2
, ubiquitin thiolesterase 2
, ubiquitin-specific-processing protease testis
, family of cysteine protease
, ubiquitin specific protease 41
, ubiquitin specific protease 46
, ubiquitin specific protease 52
, ubiquitin specific protease 66