Ubiquitin Specific Peptidase 2 Proteins (USP2)

Human Ubiquitin Specific Peptidase 2 (USP2) interaction partners

1. In general, we collect and summarize the factors involved in the alternative splicing of USP2 in this review to further understand the mechanism behind the USP2's alternative splicing

2. Authors show here USP2 is expressed in quiescent and activated T-cells and its expression is 50% lower in CTCL (show TSPYL2 Proteins) cell lines (MyLa2000, SeAx and Hut-78) than in normal T-cells.

3. Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 (show USP21 Proteins) contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.

4. The results show a connection between miR (show MLXIP Proteins)-125b and USP2 gene the etiology of psoriasis. They proceeded to show that modulation of nuclear factor kappa B-mediated inflammation is the likely mechanism through which this miRNA gene pair function

5. the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1 (show STAT1 Proteins), and inhibits K48-linked ubiquitination and degradation of pY701-STAT1 (show STAT1 Proteins)

6. ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle (show C13orf15 Proteins), DNA repair, and tumor cell growth.

7. Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (show LDLR Proteins) by IDOL (show MYLIP Proteins).

8. Data suggest up-regulation of ASAH1 (acid ceramidase (show ASAH1 Proteins)) activity by androgen in androgen-sensitive prostate cancer cells (but not other cancer cells) is mainly due to prolonged stability of ASAH1 (show ASAH1 Proteins) by androgen-stimulated induction of USP2 expression.

9. Modulation of USP-2 expression plays a crucial role in cell cycle regulation by leptin and adiponectin.

10. The present study showed that USP2 expression is associated with TNBC cell line's invasiveness and poor survival of breast cancer patients and may serve as a prognostic biomarker and therapeutic target for TNBC

Mouse (Murine) Ubiquitin Specific Peptidase 2 (USP2) interaction partners

1. 3,3'-Diindolylmethane directly inhibits USP2 deubiquitinase activity in 3T3-L1 pre-adipocytes.

2. Usp2 is required for the PTH1 (show PTH Proteins)-34-induced proliferation of osteoblasts

3. Usp2 is a clock output effector related to bodily Ca2 (show CA2 Proteins)+ homeostasis, a feature that is conserved across evolution.

4. A novel function of USP2 in the molecular clock in which it regulates PER1 (show PER1 Proteins) function.

5. A role for USP2-45 as a central regulator of MR, able to remove the receptor monoubiquitylation and induced its destabilization.

6. Data suggest that USP2 does not play a primary role in the control of sodium balance or blood pressure.

7. a functional liver clock is required for the proper nutritional and circadian regulation of USP2-45 expression; at the molecular level, transcriptional coactivators PGC-1alpha and PGC-1beta and repressor E4BP4 (show NFIL3 Proteins) exert opposing effects on USP2-45 promoter activity

8. USP2a potentially mediates circadian disruption by suppressing the CRY1 (show CRY1 Proteins) degradation during inflammation.

9. Rhythmic expression of USP2 in the SCN (show SRI Proteins) and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes

10. severe defect in the ability of Usp2 -/- spermatozoa to fertilize eggs