Ubiquitin Specific Peptidase 21 Proteins (USP21)

Human Ubiquitin Specific Peptidase 21 (USP21) interaction partners

1. Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.

2. Data show that ubiquitin variants (Ubvs) that bind to USP2 (show USP2 Proteins) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.

3. USP21 binds to the promoter region of IL-8 (show IL8 Proteins) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (show MOK Proteins)

4. USP21 interacts with, deubiquitinates and stabilizes BRCA2 (show BRCA2 Proteins) to promote efficient RAD51 (show RAD51 Proteins) loading at DNA double-strand breaks.

5. a critical role of p38 (show CRK Proteins)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Proteins)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.

6. USP21 recruits and stabilises Gli1 (show GLI1 Proteins) at the centrosome.

7. USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG

8. Data show that SUMOylated BANP (show BANP Proteins), E5R, and Nac1 (show NACC1 Proteins) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (show NKX2-1 Proteins)-interacting protein 5 (show CAPS Proteins) (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase

9. The protein stability of IL-33 (show IL33 Proteins) is maintained by USP21 through deubiquitination

10. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (show GATA3 Proteins)

Mouse (Murine) Ubiquitin Specific Peptidase 21 (USP21) interaction partners

1. USP21 recruits and stabilises Gli1 (show GLI1 Proteins) at the centrosome.

2. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation

3. Overexpression of USP21 inhibited RNA virus-induced RIG-I (show DDX58 Proteins) polyubiquitination and RIG-I (show DDX58 Proteins)-mediated interferon (show IFNA Proteins) signaling, while USP21 deletion resulted in elevated RIG-I (show DDX58 Proteins) polyubiquitination, IRF3 (show IRF3 Proteins) phosphorylation, IFN production, and antiviral responses.

4. USP21 plays an important role in the down-regulation of TNFalpha (show TNF Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation through deubiquitinating RIP1 (show RALBP1 Proteins).