Ubiquitin Specific Peptidase 21 Proteins (USP21)

USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. Additionally we are shipping USP21 Antibodies (101) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP21 27005 Q9UK80
Mouse USP21 USP21 30941 Q9QZL6
USP21 688466 B2GUX4
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Top USP21 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

USP21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

More Proteins for Ubiquitin Specific Peptidase 21 (USP21) Interaction Partners

Human Ubiquitin Specific Peptidase 21 (USP21) interaction partners

  1. Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.

  2. Data show that ubiquitin variants (Ubvs) that bind to USP2 (show USP2 Proteins) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.

  3. USP21 binds to the promoter region of IL-8 (show IL8 Proteins) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (show MOK Proteins)

  4. USP21 interacts with, deubiquitinates and stabilizes BRCA2 (show BRCA2 Proteins) to promote efficient RAD51 (show RAD51 Proteins) loading at DNA double-strand breaks.

  5. a critical role of p38 (show CRK Proteins)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Proteins)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.

  6. USP21 recruits and stabilises Gli1 (show GLI1 Proteins) at the centrosome.

  7. USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG

  8. Data show that SUMOylated BANP (show BANP Proteins), E5R, and Nac1 (show NACC1 Proteins) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (show NKX2-1 Proteins)-interacting protein 5 (show CAPS Proteins) (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase

  9. The protein stability of IL-33 (show IL33 Proteins) is maintained by USP21 through deubiquitination

  10. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (show GATA3 Proteins)

Mouse (Murine) Ubiquitin Specific Peptidase 21 (USP21) interaction partners

  1. USP21 recruits and stabilises Gli1 (show GLI1 Proteins) at the centrosome.

  2. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation

  3. Overexpression of USP21 inhibited RNA virus-induced RIG-I (show DDX58 Proteins) polyubiquitination and RIG-I (show DDX58 Proteins)-mediated interferon (show IFNA Proteins) signaling, while USP21 deletion resulted in elevated RIG-I (show DDX58 Proteins) polyubiquitination, IRF3 (show IRF3 Proteins) phosphorylation, IFN production, and antiviral responses.

  4. USP21 plays an important role in the down-regulation of TNFalpha (show TNF Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation through deubiquitinating RIP1 (show RALBP1 Proteins).

USP21 Protein Profile

Protein Summary

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with USP21

  • ubiquitin specific peptidase 21 (USP21)
  • ubiquitin specific peptidase 21 (Usp21)
  • ESTM28 protein
  • Usp16 protein
  • USP21 protein
  • Usp23 protein
  • W53272 protein

Protein level used designations for USP21

ubiquitin specific peptidase 21 , Ubiquitin specific peptidase 21 , NEDD8-specific protease , deubiquitinating enzyme 21 , ubiquitin carboxyl-terminal hydrolase 21 , ubiquitin specific protease 21 , ubiquitin thioesterase 21 , ubiquitin thiolesterase 21 , ubiquitin-specific processing protease 21 , ubiquitin-specific protease 16 , ubiquitin-specific-processing protease 21 , ubiquitin specific protease 23 , ubiquitin-specific protease 21

469556 Pan troglodytes
478979 Canis lupus familiaris
719894 Macaca mulatta
100028924 Monodelphis domestica
100066197 Equus caballus
100152455 Sus scrofa
100413038 Callithrix jacchus
100431690 Pongo abelii
100483223 Ailuropoda melanoleuca
100601460 Nomascus leucogenys
27005 Homo sapiens
534273 Bos taurus
30941 Mus musculus
688466 Rattus norvegicus
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