Ubiquitin Specific Peptidase 4 Proteins (USP4)

Human Ubiquitin Specific Peptidase 4 (USP4) interaction partners

1. Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues.

2. The data indicate that USP4 interacts with and deubiquitinates IRF4 (show IRF4 Proteins), and also stabilizes IRF4 (show IRF4 Proteins) protein and promotes IRF4 (show IRF4 Proteins) function to facilitate IL-4 (show IL4 Proteins) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.

3. These results identify USP4 as a novel regulator of Dvl (show DVL2 Proteins) in Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal and show its involvement in Wnt3a (show WNT3A Proteins)-induced osteoblast differentiation

4. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8 (show IRF8 Proteins)) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 (show IRF8 Proteins) protein levels in regulatory T-lymphocytes; USP4 and IRF8 (show IRF8 Proteins) are also expressed in helper T-lymphocytes.

5. USP4 inhibits p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) through deubiquitinating and stabilizing HDAC2 (show HDAC2 Proteins)

6. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1 (show RNPS1 Proteins).

7. Data indicate that programmed cell death 4 (PDCD4 (show PDCD4 Proteins)) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.

8. Ubiquitin-specific protease 4 (USP4), recently identified as a beta (show SUCLA2 Proteins)-catenin (show CTNNB1 Proteins)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (show CTNNB1 Proteins) protein.

9. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

10. USP4 cooperates with CtIP (show RBBP8 Proteins) in DNA double-strand break end resection.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) interaction partners

1. In this study, we identified ubiquitin-specific protease 4 (USP4), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 enhances myogenesis by controlling MyoD (show MYOD1 Proteins) and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner

2. The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 Proteins).

3. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

4. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 Proteins) type I receptor (show TGFBR1 Proteins) and AKT (show AKT1 Proteins) signalling pathways.

5. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 Proteins) levels.

6. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.