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USP48 encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Additionally we are shipping USP48 Antibodies (42) and and many more products for this protein.
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Human USP48 Protein expressed in Wheat germ - ABIN1324823
Schweitzer, Naumann: CSN-associated USP48 confers stability to nuclear NF-?B/RelA by trimming K48-linked Ub-chains. in Biochimica et biophysica acta 2015
USP48 and BRAF mutations have a role in Cushing's disease
USP48 inactivation reduces chromosomal instability of Fanconi anemia (FA)-defective cells. Our results highlight a role for USP48 in controlling DNA repair and suggest it as a potential target that could be therapeutically exploited for FA.
In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels.
down-regulation of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stability
study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis.
Data suggest that ubiquitin specific protease-48 (USP48) promotes genome stability by antagonizing BRCA1 E3 ligase function.
this study demonstrates that USP48 controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB/RelA in the nucleus.
Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung.
The Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta-mediated NF-kappaB activation, but did not inhibit Smad-mediated transcription activation.
data demonstrate a crucial role for the dynamic interaction between D3R and USP48 in the regulation of NHE3 expression and function
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme 48
, ubiquitin carboxyl-terminal hydrolase 48
, ubiquitin specific protease 31
, ubiquitin specific protease 48
, ubiquitin thioesterase 48
, ubiquitin thiolesterase 48
, ubiquitin-specific-processing protease 48
, synaptic ubiquitin-specific protease
, ubiquitin specific peptidase 48
, ubiquitin carboxyl-terminal hydrolase 48-like