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UBE2W encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2W (Putative) Proteins (16) and many more products for this protein.
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Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways.
TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.
We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group
Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates
UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6.
human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals
Study shows the absence of ubiquitin conjugating enzyme Ube2W in HdhQ200 knock-in mice increases levels of soluble monomeric mutant huntingtin while reducing insoluble oligomeric species. This study sheds light on the potential function of the non-canonical ubiquitin-conjugating enzyme, Ube2W, in this polyQ neurodegenerative disease.
results establish that UBE2W is an important, albeit not essential, protein for early postnatal survival and normal functioning of multiple organ systems.
This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
ubiquitin-conjugating enzyme E2W (putative)
, probable ubiquitin-conjugating enzyme E2 W
, probable ubiquitin-conjugating enzyme E2 W-A
, ubiquitin carrier protein W
, ubiquitin carrier protein W-A
, ubiquitin-protein ligase W
, ubiquitin-protein ligase W-A
, ubiquitin-conjugating enzyme 16
, ubiquitin-conjugating enzyme 2W
, ubiquitin-conjugating enzyme E2 W
, putative ubiquitin-conjugating enzyme E2 W
, Ubiquitin carrier protein W
, Ubiquitin-protein ligase W
, Probable ubiquitin-conjugating enzyme E2 W
, ubiquitin-conjugating enzyme E2 W-like