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Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane.
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The authors identify USP13 (show USP13 Antibodies) as a gp78 (show AMFR Antibodies)-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6 (show BAT3 Antibodies).
Data show that molecular chaperone (show HSP90AA1 Antibodies) BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA (show SGTA Antibodies) protein (SGTA_NT).
Both TRC35 (show C7orf20 Antibodies) and Ubl4A have distinct C-terminal binding sites on Bag6 (show BAT3 Antibodies) defining a minimal Bag6 (show BAT3 Antibodies) complex.
Data indicate that BCL2-associated athanogene 6 (BAG6 (show BAT3 Antibodies)) appears to be the central component for the process, as depletion of BAG6 (show BAT3 Antibodies) leads to the loss of both UBL4A and GET4 (show C7orf20 Antibodies) proteins and resistance to cell killing by DNA-damaging agents.
Data indicate that the Bag6 (show BAT3 Antibodies)-Ubl4A-Trc35 (show C7orf20 Antibodies) complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD).
SGTA (show SGTA Antibodies) recognizes a noncanonical ubiquitin-like domain in the Bag6 (show BAT3 Antibodies)-Ubl4A-Trc35 (show C7orf20 Antibodies) complex to promote endoplasmic reticulum-associated degradation.
Structures of the Sgt2 (show PPFIBP1 Antibodies)/SGTA (show SGTA Antibodies) dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
The results uncovered GdX as a novel regulator in bone development and a potential candidate gene for skeletal dysplasias.
Ubl4A has a role in fibroblast and macrophage migration-associated pathophysiological processes
ubiquitin-like protein 4A (Ubl4A) plays a crucial role in insulin (show INS Antibodies)-induced Akt (show AKT1 Antibodies) plasma membrane translocation.
Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6 (show BAT3 Antibodies)) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a).
GdX converts TC45, a nonspecific phosphatase, into a STAT3 (show STAT3 Antibodies)-specific phosphatase by bridging an association between TC45 and STAT3 (show STAT3 Antibodies)
GdX knockout male mice are functionally normal in the reproductive system where Ubl4B was specifically expressed.
Ubl4 gave rise to an autosomal germ cell-specific intronless gene Ubl4b.
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region (By similarity).
, ubiquitin-like protein 4A
, ubiquitin-like protein GDX
, housekeeping protein DXS254E
, ubiquitin-like 4A
, Ubiquitin-like protein 4A
, P3 protein
, solute carrier family 10 (sodium/bile acid cotransporter family), member 3