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UMOD encodes uromodulin, the most abundant protein in normal urine. Additionally we are shipping Uromodulin Antibodies (192) and Uromodulin Kits (69) and many more products for this protein.
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these data support THP as an important negative regulator of neutrophil activation in the urinary tract, with dual functions to counteract bacterial colonization and suppress excessive inflammation within the urinary tract
Homozygous UMOD mutation did not show a strikingly more severe clinical evolution nor was the near absence of urinary uromodulin associated with urinary tract infections or kidney stones.
we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.
Studied genetic association of uromodulin SNP in kidney function of patients with hypertension and cardiovascular disease.
Single-nucleotide polymorphism in UMOD gene is associated with type 2 diabetes.
UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.
The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.
Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).
THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
High urinary uromodulin levels are associated with lower risk for UTI (show AMBP Proteins) in older community-dwelling adults independent of traditional UTI (show AMBP Proteins) risk factors.
this study shows that uromodulin-SlpA (show SEPT9 Proteins) binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells
results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses
Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.
Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (show IL17A Proteins) axis and systemic neutrophilia.
TNFalpha (show TNF Proteins) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (show TNF Proteins) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (show HNF1B Proteins)-mediated expression of uromodulin.
AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (show TLR4 Proteins) may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (show TRPV5 Proteins) by decreasing caveolin-1 (show CAV1 Proteins) dependent endocytosis of TRPV5 (show TRPV5 Proteins).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (show TNF Proteins) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein