Uromodulin Proteins (UMOD)

UMOD encodes uromodulin, the most abundant protein in normal urine. Additionally we are shipping Uromodulin Antibodies (185) and Uromodulin Kits (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UMOD 7369 P07911
UMOD 22242 Q91X17
UMOD 25128 P27590
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Top Uromodulin Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$755.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,697.83
Details
Human Human Un-conjugated   100 μg Log in to see 6 to 8 Days
$602.64
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 18 Days
$723.00
Details
Escherichia coli (E. coli) Dog Un-conjugated 100 μg Log in to see 15 to 18 Days
$768.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details

UMOD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,
,

More Proteins for Uromodulin (UMOD) Interaction Partners

Human Uromodulin (UMOD) interaction partners

  1. Studied genetic association of uromodulin SNP in kidney function of patients with hypertension and cardiovascular disease.

  2. Single-nucleotide polymorphism in UMOD gene is associated with type 2 diabetes.

  3. UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.

  4. The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.

  5. Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).

  6. THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.

  7. High urinary uromodulin levels are associated with lower risk for UTI (show AMBP Proteins) in older community-dwelling adults independent of traditional UTI (show AMBP Proteins) risk factors.

  8. The uromodulin-CFH (show CFH Proteins) interaction enhanced the cofactor activity of CFH (show CFH Proteins) for factor I-mediated cleavage of C3b to inactivated C3b.

  9. These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.

  10. Data strongly suggest that the uromodulin ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of its protective effect against urinary tract infections

Mouse (Murine) Uromodulin (UMOD) interaction partners

  1. results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses

  2. Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.

  3. Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.

  4. we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (show IL17A Proteins) axis and systemic neutrophilia.

  5. TNFalpha (show TNF Proteins) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (show TNF Proteins) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (show HNF1B Proteins)-mediated expression of uromodulin.

  6. AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (show TLR4 Proteins) may contribute to its anti-inflammatory effects.

  7. UMOD upregulates TRPV5 (show TRPV5 Proteins) by decreasing caveolin-1 (show CAV1 Proteins) dependent endocytosis of TRPV5 (show TRPV5 Proteins).

  8. UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (show TNF Proteins) on NKCC2A expression, making UMOD an important determinant of blood pressure control.

  9. Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.

  10. Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.

Cow (Bovine) Uromodulin (UMOD) interaction partners

Uromodulin (UMOD) Protein Profile

Protein Summary

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with Uromodulin Proteins (UMOD)

  • uromodulin (UMOD)
  • uromodulin (Umod)
  • ADMCKD2 protein
  • FJHN protein
  • HNFJ protein
  • HNFJ1 protein
  • MCKD2 protein
  • THGP protein
  • THP protein
  • urehr4 protein

Protein level used designations for Uromodulin Proteins (UMOD)

uromodulin , Tamm-Horsfall urinary glycoprotein , uromucoid , THP , tamm-Horsfall urinary glycoprotein , uromodulin (uromucoid, Tamm-Horsfall glycoprotein) , Urmodulin (Tamm-Horsfall protein) , uromucoid, human : Tamm-Horsfall glycoprotein

GENE ID SPECIES
695883 Macaca mulatta
100026222 Monodelphis domestica
7369 Homo sapiens
403510 Canis lupus familiaris
22242 Mus musculus
25128 Rattus norvegicus
281567 Bos taurus
100730507 Cavia porcellus
100173805 Pongo abelii
100511125 Sus scrofa
100342440 Oryctolagus cuniculus
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