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VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Proteins (37) and VTCN1 Kits (28) and many more products for this protein.
Showing 10 out of 208 products:
Human Polyclonal VTCN1 Primary Antibody for IHC, ELISA - ABIN1584048
Basta, Galazka, Mach, Jozwicki, Walentowicz, Wicherek: The immunohistochemical analysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied therapeutic surgery and surgery followed by chemotherapy. in American journal of reproductive immunology (New York, N.Y. : 1989) 2011
Show all 5 Pubmed References
Human Monoclonal VTCN1 Primary Antibody for FACS - ABIN2688846
Sica, Choi, Zhu, Tamada, Wang, Tamura, Chapoval, Flies, Bajorath, Chen: B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. in Immunity 2003
Show all 3 Pubmed References
Human Polyclonal VTCN1 Primary Antibody for IHC, IHC (p) - ABIN4282807
Xu, Zhang, Zhang, Liu, Yin, Liu, Zhuo: Clinical relevance of expression of B7-H1 and B7-H4 in ovarian cancer. in Oncology letters 2016
Show all 2 Pubmed References
Human Polyclonal VTCN1 Primary Antibody for CyTOF, FACS - ABIN4900129
Radichev, Maneva-Radicheva, Amatya, Salehi, Parker, Ellefson, Burn, Savinov: Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Mouse (Murine) Polyclonal VTCN1 Primary Antibody for FACS, WB - ABIN4900128
Lee, Scandiuzzi, Ray, Wei, Hofmeyer, Abadi, Loke, Lin, Yuan, Serreze, Allison, Zang: B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 2 Pubmed References
Human Polyclonal VTCN1 Primary Antibody for FACS, IF (p) - ABIN671736
Maskey, Li, Hu, Xu, Peng, Yu, Cao, Chen, Li, Yang: Impact of neoadjuvant chemotherapy on lymphocytes and co-inhibitory B7-H4 molecule in gastric cancer: low B7-H4 expression associates with favorable prognosis. in Tumour biology 2014
Human Polyclonal VTCN1 Primary Antibody for ELISA, WB - ABIN451629
Krambeck, Thompson, Dong, Lohse, Park, Kuntz, Leibovich, Blute, Cheville, Kwon: B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. in Proceedings of the National Academy of Sciences of the United States of America 2006
Human Monoclonal VTCN1 Primary Antibody for FACS - ABIN2477567
van de Ven, van den Hout, Lindenberg, Sluijter, van Leeuwen, Lougheed, Meijer, van den Tol, Scheper, de Gruijl: Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation. in Blood 2011
this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.
Ablation of B7-H3 (show CD276 Antibodies) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A Antibodies) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
The decrease of B7-H4 expression in salivary glands of Sjogren's syndrome patients contributes to the defect of negatively regulating the inflammation caused by CD4 (show CD4 Antibodies)(+) T cells.
Preclinical investigation into B7-H4-specific chimeric antigen receptor (CAR) T cells, antibody-mediated blockade of B7-H4, and anti-B7-H4 drug conjugates has shown antitumor efficacy in mouse models.
This meta-analysis demonstrated that high B7-H4 expression is an unfavorable prognostic factor in NSCLC.
This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors.
in pulmonary adenocarcinoma presenting with SPN (show SPN Antibodies), nuclear membrane localization of B7-H4 within the tumor cells is associated with increased malignancy
Study reportes that B7-H3 (show CD276 Antibodies) and B7-H4 are highly expressed in human esophageal cancer tissues and significantly associated with tumor invasion.
Results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis.
PD-L1 (show CD274 Antibodies), IDO-1 (show IDO1 Antibodies), and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 (show CD274 Antibodies) and IDO-1 (show IDO1 Antibodies) are associated with increased tumor-infiltrating lymphoycte and IFN-gamma (show IFNG Antibodies) stimulation, B7-H4 is not.
B7-H4 activation on Mphis/microglia in the microenvironment of gliomas is an important immunosuppressive event blocking effective T-cell immune responses.
Knockdown of B7-H4 significantly up-regulated 57 miRNAs and down-regulated 14 miRNAs.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x