anti-V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) Antibodies

VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Proteins (49) and VTCN1 Kits (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VTCN1 242122 Q7TSP5
VTCN1 79679 Q7Z7D3
VTCN1 295322 Q501W4
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Top anti-VTCN1 Antibodies at antibodies-online.com

Showing 10 out of 215 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN334524 (0.3µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of VTCN1 Antibody (Center) in T47D cell line lysates (35 µg/lane). VTCN1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human thyroid carcinoma labeled Anti-B7H4 Polyclonal Antibody, Unconjugated (ABIN671736) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled Anti-B7H4 Polyclonal Antibody, Unconjugated (ABIN671736) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Goat Un-conjugated CyTOF, FACS, WB Detection of Mouse and Human B7-H4 by Western Blot. Western blot shows lysates of mouse placenta tissue, mouse uterus tissue, and SK-BR-3 human breast cancer cell line. PVDF membrane was probed with 2 ug/mL of Goat Anti-Mouse B7-H4 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$416.97
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human B7-H4/Vtcn1/B7S1 Immunohistochemistry(IHC) 7760 Human B7-H4/Vtcn1/B7S1 Immunohistochemistry(IHC) 7761 100 μg Log in to see 14 to 16 Days
$247.82
Details
Human Mouse Un-conjugated FACS, IHC (fro), IHC (p) 0.2 mg Log in to see 6 to 8 Days
$533.50
Details
Human Mouse PE FACS, IHC, IHC (fro), IHC (p) 100 Tests Log in to see 11 to 14 Days
$610.50
Details

Top referenced anti-VTCN1 Antibodies

  1. Human Monoclonal VTCN1 Primary Antibody for FACS - ABIN2688846 : Sica, Choi, Zhu, Tamada, Wang, Tamura, Chapoval, Flies, Bajorath, Chen: B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. in Immunity 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal VTCN1 Primary Antibody for CyTOF, FACS - ABIN4900129 : Radichev, Maneva-Radicheva, Amatya, Salehi, Parker, Ellefson, Burn, Savinov: Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes. in Journal of immunology (Baltimore, Md. : 1950) 2016 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal VTCN1 Primary Antibody for IHC, IHC (p) - ABIN4282807 : Xu, Zhang, Zhang, Liu, Yin, Liu, Zhuo: Clinical relevance of expression of B7-H1 and B7-H4 in ovarian cancer. in Oncology letters 2016 (PubMed)
    Show all 2 Pubmed References

  4. Mouse (Murine) Polyclonal VTCN1 Primary Antibody for FACS, WB - ABIN4900128 : Lee, Scandiuzzi, Ray, Wei, Hofmeyer, Abadi, Loke, Lin, Yuan, Serreze, Allison, Zang: B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal VTCN1 Primary Antibody for FACS, IF (p) - ABIN671736 : Maskey, Li, Hu, Xu, Peng, Yu, Cao, Chen, Li, Yang: Impact of neoadjuvant chemotherapy on lymphocytes and co-inhibitory B7-H4 molecule in gastric cancer: low B7-H4 expression associates with favorable prognosis. in Tumour biology 2014 (PubMed)

  6. Human Monoclonal VTCN1 Primary Antibody for FACS - ABIN2477567 : van de Ven, van den Hout, Lindenberg, Sluijter, van Leeuwen, Lougheed, Meijer, van den Tol, Scheper, de Gruijl: Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation. in Blood 2011 (PubMed)

  7. Human Polyclonal VTCN1 Primary Antibody for ELISA, WB - ABIN451629 : Krambeck, Thompson, Dong, Lohse, Park, Kuntz, Leibovich, Blute, Cheville, Kwon: B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

More Antibodies against VTCN1 Interaction Partners

Mouse (Murine) V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. B7S1 initiates dysfunction of tumor-infiltrating CD8+ T cells and may be targeted for cancer immunotherapy.

  2. In the Title.

  3. this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors

  4. Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.

  5. Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

  6. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

  7. that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease

  8. B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (

  9. The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.

  10. Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 T cell-induced diabetes.

  11. An enhanced T cell response contributes to reduced lethality in a pulmonary infection model with Streptococcus pneumoniae.

  12. B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.

  13. Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.

  14. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.

  15. intact recipient, but not donor, B7-H4 is essential for prolongation of allograft survival by blocking CD28/CTLA4:B7 pathway using CTLA4-Ig.

  16. studies reveal a novel role for activated hepatic stellate cells in the attenuation of intrahepatic T cell responses by way of expression of the coinhibitory molecule B7-H4.

  17. May participate in negative regulation of cell-mediated immunity in peripheral tissues

  18. novel negative costimulator and regulates the threshold of T cell activation

  19. Genomic DNA of mouse B7-H4 is mapped on chromosome 3 comprised of six exons and five introns spanning 66 kb.

  20. These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses.

Human V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

  2. B7-H4/NF-kappaB signaling is involved in the EMT and invasion of bladder cancer cells.

  3. The aim of the present work was to evaluate the effectiveness of anti-B7-H4-scFv-CH3 against tumors in vitro and in vivo. ScFv can inhibit signaling pathways to improve immunity by binding with the T lymphocyte negative co-stimulatory factor B7-H4.

  4. High B7-H4 expression is associated with phyllodes tumors.

  5. Studies suggest that V-set domain containing T cell activation inhibitor 1 protein (B7S1) may represent a very promising candidate to be targeted to treat various tumors.

  6. Human Immunodeficiency virus type-1 myeloid derived suppressor cells inhibit cytomegalovirus inflammation through IL-27 and B7-H4.

  7. High B7-H4 expression is associated with glioblastoma.

  8. Serum B7-H4 detection, either alone or in combination with carbohydrate antigen 125, has an acceptable value in the diagnosis of OC.

  9. the findings of this study suggested that B7-H4 may have the potential to be a valuable prognostic marker and a target for individualized therapies for gastric cancer

  10. Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.

  11. B7-H3 protein is expressed in the majority of NSCLCs and is associated with smoking history. High levels of B7-H3 protein have a negative prognostic impact in lung carcinomas. Coexpression of B7-H3 with PD-L1 and B7-H4 is relatively low, suggesting a nonredundant biological role of these targets.

  12. When compared to early-stage lung adenocarcinoma, metastatic pleural adenocarcinoma possessed higher level of nuclei membranous B7-H4 and lower cytoplasmic B7-H4 expression.

  13. The decrease of B7-H4 expression in salivary glands of Sjogren's syndrome patients contributes to the defect of negatively regulating the inflammation caused by CD4(+) T cells.

  14. Preclinical investigation into B7-H4-specific chimeric antigen receptor (CAR) T cells, antibody-mediated blockade of B7-H4, and anti-B7-H4 drug conjugates has shown antitumor efficacy in mouse models.

  15. This meta-analysis demonstrated that high B7-H4 expression is an unfavorable prognostic factor in NSCLC.

  16. This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors.

  17. in pulmonary adenocarcinoma presenting with SPN, nuclear membrane localization of B7-H4 within the tumor cells is associated with increased malignancy

  18. Study reportes that B7-H3 and B7-H4 are highly expressed in human esophageal cancer tissues and significantly associated with tumor invasion.

  19. Results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis.

  20. PD-L1, IDO-1, and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 and IDO-1 are associated with increased tumor-infiltrating lymphoycte and IFN-gamma stimulation, B7-H4 is not.

VTCN1 Antigen Profile

Protein Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with VTCN1

  • V set domain containing T cell activation inhibitor 1 L homeolog (vtcn1.L) antibody
  • V-set domain containing T cell activation inhibitor 1 (VTCN1) antibody
  • V-set domain containing T-cell activation inhibitor 1 (VTCN1) antibody
  • V set domain containing T cell activation inhibitor 1 (vtcn1) antibody
  • V-set domain containing T cell activation inhibitor 1 (Vtcn1) antibody
  • B7-H4 antibody
  • B7h.5 antibody
  • B7H4 antibody
  • B7S1 antibody
  • B7X antibody
  • BC032925 antibody
  • PRO1291 antibody
  • RGD1311204 antibody
  • VCTN1 antibody

Protein level used designations for VTCN1

V-set domain-containing T-cell activation inhibitor 1 , V-set domain containing T cell activation inhibitor 1 , V-set domain containing T-cell activation inhibitor 1 , immune costimulatory protein B7-H4 , t cell costimulatory molecule B7x , B7 family member, H4 , B7 superfamily member 1 , T cell costimulatory molecule B7x , T-cell costimulatory molecule B7x

GENE ID SPECIES
379070 Xenopus laevis
418323 Gallus gallus
469433 Pan troglodytes
493551 Xenopus (Silurana) tropicalis
242122 Mus musculus
79679 Homo sapiens
295322 Rattus norvegicus
Selected quality suppliers for anti-VTCN1 (VTCN1) Antibodies
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