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VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Antibodies (208) and VTCN1 Proteins (37) and many more products for this protein.
Showing 10 out of 28 products:
Human VTCN1 ELISA Kit for Sandwich ELISA - ABIN808999
Liu, Chen, Zhu, Li, Xu, Wu, Guo, Wang: B7-H4 expression in bladder urothelial carcinoma and immune escape mechanisms. in Oncology letters 2014
Human VTCN1 ELISA Kit for Sandwich ELISA - ABIN649160
Geng, Wang, Lu, Li, Xu, Jiang, Wu: Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance. in International journal of clinical oncology 2015
this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.
Ablation of B7-H3 (show CD276 ELISA Kits) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A ELISA Kits) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
The decrease of B7-H4 expression in salivary glands of Sjogren's syndrome patients contributes to the defect of negatively regulating the inflammation caused by CD4 (show CD4 ELISA Kits)(+) T cells.
Preclinical investigation into B7-H4-specific chimeric antigen receptor (CAR) T cells, antibody-mediated blockade of B7-H4, and anti-B7-H4 drug conjugates has shown antitumor efficacy in mouse models.
This meta-analysis demonstrated that high B7-H4 expression is an unfavorable prognostic factor in NSCLC.
This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors.
in pulmonary adenocarcinoma presenting with SPN (show SPN ELISA Kits), nuclear membrane localization of B7-H4 within the tumor cells is associated with increased malignancy
Study reportes that B7-H3 (show CD276 ELISA Kits) and B7-H4 are highly expressed in human esophageal cancer tissues and significantly associated with tumor invasion.
Results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis.
PD-L1 (show CD274 ELISA Kits), IDO-1 (show IDO1 ELISA Kits), and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 (show CD274 ELISA Kits) and IDO-1 (show IDO1 ELISA Kits) are associated with increased tumor-infiltrating lymphoycte and IFN-gamma (show IFNG ELISA Kits) stimulation, B7-H4 is not.
B7-H4 activation on Mphis/microglia in the microenvironment of gliomas is an important immunosuppressive event blocking effective T-cell immune responses.
Knockdown of B7-H4 significantly up-regulated 57 miRNAs and down-regulated 14 miRNAs.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x