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VTCN1 encodes a protein belonging to the B7 costimulatory protein family.
Showing 10 out of 29 products:
Human VTCN1 ELISA Kit for Sandwich ELISA - ABIN808999
Liu, Chen, Zhu, Li, Xu, Wu, Guo, Wang: B7-H4 expression in bladder urothelial carcinoma and immune escape mechanisms. in Oncology letters 2014
Human VTCN1 ELISA Kit for Sandwich ELISA - ABIN649160
Geng, Wang, Lu, Li, Xu, Jiang, Wu: Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance. in International journal of clinical oncology 2015
this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.
Ablation of B7-H3 (show CD276 ELISA Kits) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A ELISA Kits) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
B7-H3 (show CD276 ELISA Kits) protein is expressed in the majority of NSCLCs and is associated with smoking history. High levels of B7-H3 (show CD276 ELISA Kits) protein have a negative prognostic impact in lung carcinomas. Coexpression of B7-H3 (show CD276 ELISA Kits) with PD-L1 (show CD274 ELISA Kits) and B7-H4 is relatively low, suggesting a nonredundant biological role of these targets.
When compared to early-stage lung adenocarcinoma, metastatic pleural adenocarcinoma possessed higher level of nuclei membranous B7-H4 and lower cytoplasmic B7-H4 expression.
The decrease of B7-H4 expression in salivary glands of Sjogren's syndrome patients contributes to the defect of negatively regulating the inflammation caused by CD4 (show CD4 ELISA Kits)(+) T cells.
Preclinical investigation into B7-H4-specific chimeric antigen receptor (CAR) T cells, antibody-mediated blockade of B7-H4, and anti-B7-H4 drug conjugates has shown antitumor efficacy in mouse models.
This meta-analysis demonstrated that high B7-H4 expression is an unfavorable prognostic factor in NSCLC.
This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors.
in pulmonary adenocarcinoma presenting with SPN (show SPN ELISA Kits), nuclear membrane localization of B7-H4 within the tumor cells is associated with increased malignancy
Study reportes that B7-H3 (show CD276 ELISA Kits) and B7-H4 are highly expressed in human esophageal cancer tissues and significantly associated with tumor invasion.
Results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis.
PD-L1 (show CD274 ELISA Kits), IDO-1 (show IDO1 ELISA Kits), and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 (show CD274 ELISA Kits) and IDO-1 (show IDO1 ELISA Kits) are associated with increased tumor-infiltrating lymphoycte and IFN-gamma (show IFNG ELISA Kits) stimulation, B7-H4 is not.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x