anti-Vang-Like 1 (Van Gogh, Drosophila) (Vangl1) Antibodies

Zebrafish Vang-Like 1 (Van Gogh, Drosophila) (Vangl1) interaction partners

1. This study demonstrates a high degree of functional conservation of VANGL genes across evolution and provides a model system for studying potential variants identified in human neural tube defects.

2. The identification of zebrafish vangl1; the first spatiotemporal expression and functional analysis of a vertebrate vangl1 homologue are described.

Mouse (Murine) Vang-Like 1 (Van Gogh, Drosophila) (Vangl1) interaction partners

1. High KITENIN expression is associated with cholangiocarcinoma.

2. In Pax2-Cre; V1V2 Conditional knockout mice, the loss of both VANGL proteins significantly disrupts planar polarity throughout the utricular maculae

3. Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP factors by electroporation revealed that Vangl1, Vangl2 and Prickle2 are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model

4. Elevated coexpression of KITENIN and ErbB4-CYT-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment

5. Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis.

6. Vangl1 and Vangl2 may play a key role in the embryo implantation of mice

7. Vangl does not have a critical role in neural crest migration through planar cell polarity signaling

8. Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified.

9. Vangl1 transcript downregulation might be implicated in the occurrence of mouse NTDs induced by retinoic acid.

10. critical role for normal folding and processing of Vangl proteins, with highly conservative substitutions not tolerated at that site; mutations associated with tail abnormalities in mice.

11. Genetic interaction between Vangl1 and Vangl2 genes causes neural tube defects. Vangl1(gt/+);Vangl2(lp/+) double heterozygotes show profound developmental defects

Human Vang-Like 1 (Van Gogh, Drosophila) (Vangl1) interaction partners

1. High KITENIN expression is associated with cholangiocarcinoma.

2. VANGL1 gene is not associated with Adolescent Idiopathic Scoliosis in the Chinese population

3. two rare missense mutations in VANGL1, encoding a receptor involved in WNT/PCP signaling, may be associated with Adolescent Idiopathic Scoliosis

4. Study provides evidence that KITENIN functions in the maintenance of a higher expression level of ErbB4 in advanced colorectal cancer tissues, independent of ubiquitin-mediated degradation via Nrdp1.

5. We first propose the use of a DNA biosensor to detect the missense single nucleotide polymorphism (rs4839469 c.346G>A p.Ala116Thr) of the vangl1 gene

6. a novel and ultrasensitive sandwich-type immunosensor was fabricated to detect Vangl in human serum using C60-templated AuPt as labels and rGO-TEPA-PTC-NH2 as the platform.

7. Results found that KITENIN is associated with tumor progression by enhancing angiogenesis in colorectal cancer.

8. Authors silenced VANGL1 gene expression in the HepG2 HCC cell line by stable transfection with a vector containing siRNA template for VANGL1 and investigated the change in cell invasion and motility.

9. High levels of KITENIN increased glioma invasiveness and progression, and are associated with the up-regulation of EMT and stemness markers.

10. The rs4839469 allele of VANGL1 was obviously associated with neural tube defects (NTDs). And genotype GC increased the risk of NTDs, changes in the three-dimensional protein structure may have impacted its biological functions.

11. VANGL1 mutations are associated with neural tube defects.

12. Elevated KITENIN expression is associated with drug resistance in colorectal cancer.

13. Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis.

14. The results show that the Vangl1 amino terminus lacks PM targeting determinants, and these are restricted to the carboxy terminus, including the predicted PDZBM motif at the C-terminus

15. These results strongly suggest that R181 and R274 play critical roles in Vangl protein function and that their mutations cause neural tube defects in humans.

16. KITENIN is associated with tumor invasiveness and metastasis in human oral cavity squamous cell carcinoma.

17. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells

18. KITENIN is associated with human colorectal cancer progression including invasion and metastasis.

19. a compact membrane-associated portion with very short predicted extra- and intracellular loops, while the protein harbors a large intracellular domain

20. Loss of membrane targeting of Vangl1 and Vangl2 proteins causes neural tube defects.