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May act as a specific coactivator for the mammalian TEFs (By similarity).. Additionally we are shipping Vestigial Like 4 (Drosophila) Proteins (5) and and many more products for this protein.
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Human Polyclonal VGLL4 Primary Antibody for WB - ABIN1881992
Chen, Mullett, Stewart: Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human Polyclonal VGLL4 Primary Antibody for ICC, IF - ABIN4365266
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4.
Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion.
The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.
VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia.
The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer.
our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.
VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains.
rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa.
This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process.
Loss of VGLL4 expression is associated with gastric cancer.
Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments.
IRF2BP2 was identifies as a novel VGLL4 partner.
This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors.
Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma in a mouse model with G2/M phase arrest and apoptosis promotion.
VGLL4 inhibits cardiomyocyte proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation.
Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes
May act as a specific coactivator for the mammalian TEFs (By similarity).
transcription cofactor vestigial-like protein 4
, Vestigial-like 4