Vestigial Like 4 (Drosophila) Proteins (VGLL4)

May act as a specific coactivator for the mammalian TEFs (By similarity).. Additionally we are shipping Vestigial Like 4 (Drosophila) Antibodies (52) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat VGLL4 VGLL4 297523  
VGLL4 9686 Q14135
Mouse VGLL4 VGLL4 232334 Q80V24
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Top Vestigial Like 4 (Drosophila) Proteins at

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days

VGLL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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More Proteins for Vestigial Like 4 (Drosophila) (VGLL4) Interaction Partners

Human Vestigial Like 4 (Drosophila) (VGLL4) interaction partners

  1. Data report that VGLL4 functions as a suppressor of breast tumor (BC) growth and progression. Its low expression correlated with a poor prognosis. Its ectopic expression in BC cell lines reduced cell proliferation, migration, and tumor formation in xenograft mouse model. VGLL4 interacts with TEAD1 via its second TEAD-interacting domain, antagonizing YAP-dependent tumor growth.

  2. Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4.

  3. Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion.

  4. The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.

  5. VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia.

  6. The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer.

  7. our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.

  8. VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains.

  9. rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa.

  10. This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process.

  11. Loss of VGLL4 expression is associated with gastric cancer.

  12. Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments.

  13. IRF2BP2 was identifies as a novel VGLL4 partner.

  14. This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors.

Mouse (Murine) Vestigial Like 4 (Drosophila) (VGLL4) interaction partners

  1. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma in a mouse model with G2/M phase arrest and apoptosis promotion.

  2. VGLL4 inhibits cardiomyocyte proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation.

  3. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes

Vestigial Like 4 (Drosophila) (VGLL4) Protein Profile

Protein Summary

May act as a specific coactivator for the mammalian TEFs (By similarity).

Gene names and symbols associated with VGLL4

  • vestigial-like family member 4 (Vgll4)
  • vestigial like family member 4 (VGLL4)
  • vestigial like family member 4 (Vgll4)
  • BC048841 protein
  • DKFZp459C0333 protein
  • VGL-4 protein

Protein level used designations for VGLL4

transcription cofactor vestigial-like protein 4 , Vestigial-like 4

297523 Rattus norvegicus
415962 Gallus gallus
607588 Canis lupus familiaris
613904 Bos taurus
100171928 Pongo abelii
9686 Homo sapiens
232334 Mus musculus
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