Vestigial Like 4 (Drosophila) Proteins (VGLL4)

Human Vestigial Like 4 (Drosophila) (VGLL4) interaction partners

1. Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4.

2. Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion.

3. The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.

4. VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia.

5. The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer.

6. our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.

7. VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains.

8. rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa.

9. This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process.

10. Loss of VGLL4 expression is associated with gastric cancer.

11. Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments.

12. IRF2BP2 was identifies as a novel VGLL4 partner.

13. This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors.