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VEZT encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Additionally we are shipping Vezatin, Adherens Junctions Transmembrane Protein Kits (6) and and many more products for this protein.
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We found a genetic association between rs11031006 (FSHB (show FSHB Antibodies)) SNP and endometriosis. WNT4 (show WNT4 Antibodies) and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4 (show WNT4 Antibodies)) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
This study identified the most effective small activating RNA via real-time PCR and Western blot. The selected small activating RNA inhibited the growth, invasion and migration of gastric cancer cells by specially reactivating VEZT.
VEZT expression levels can be considered as a biomarker for gastric cancer progression, lymphatic metastasis and as a novel independent prognostic factor.
vezatin and nearby SNP rs10859871 may have a role in endometriosis [meta-analysis]
VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.
miR (show MLXIP Antibodies)-43c directly targets adherens junctions' transmembrane protein (VEZT) and suppresses VEZT protein expression.
These results suggest a role of Vezatin in dendritic spine morphogenesis and functional synaptic maturation.
present study suggests that vezatin may regulate dendritic formation as a downstream effector of ARF6 (show ARF6 Antibodies).
vezatin associates with actin filaments at cell-cell junctions.
These in vitro observations reinforce the idea that homozygous vezatin-null mutants die at the time of implantation because of a defect in intercellular adhesion.
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.
vezatin, adherens junctions transmembrane protein
, transmembrane protein vezatin