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Von Hippel-Lindau Tumor Suppressor-Like Proteins

3 results:

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-139) protein (His tag) Protein

Crystallography grade VHLL Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3075289
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Delivery in 30 to 35 Business Days

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-154) protein (His tag) Protein

VHLL Origin: Human Recombinant > 95.0 % as determined by SDS-PAGE.
Catalog No. ABIN620853
Plus shipping costs $45.00
50 μg (More quantities available)
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) Protein Protein

VHLL Origin: Human Recombinant
Catalog No. ABIN1068513
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Will be delivered in 6 Business Days
  • Type Protein
    • Protein
  • Target Von Hippel-Lindau Tumor Suppressor-Like (VHLL)
    • Von Hippel-Lindau Tumor Suppressor-Like (VHLL)
    • Hemagglutinin (HA)
    • Hemoglobin beta (HBB)
    • Ribosome Binding Factor A (RBFA)
    • Triosephosphate Isomerase 1 (TPI1)
    • S-Adenosyl-Methionine Synthase (METK)
    • Hemoglobin, alpha 1 (HBA1)
    • SARS-CoV-2 Spike
    • Myoglobin (MB)
    • Tumor Necrosis Factor alpha (TNF alpha)
    • Thymidylate Kinase (Tmk)
    • Lipoyl synthase (lipA)
    • Growth Hormone 1 (GH1)
    • Interferon gamma (IFNG)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Aspartate Carbamoyltransferase (PYRB)
    • Uracil-DNA Glycosylase (UNG)
    • Malate Dehydrogenase (MDH)
    • Phosphoglucosamine Mutase (GLMM)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • phosphatidylserine Decarboxylase (PISD)
    • Cysteinyl-tRNA Synthetase 2, Mitochondrial (Putative) (CARS2)
    • tRNA Methyltransferase 5 (TRMT5)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • Interleukin 6 (IL6)
    • Interleukin 2 (IL2)
    • Cytochrome C, Somatic (CYCS)
    • Interleukin 4 (IL4)
    • Epidermal Growth Factor Receptor (EGFR)
    • CD40 Ligand (CD40LG)
    • Gp120
    • Porphobilinogen Deaminase (HEMC)
    • Plasminogen Activator Inhibitor 1 (SERPINE1)
    • Superoxide Dismutase 1, Soluble (SOD1)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • 1-(5-Phosphoribosyl)-5-[(5-Phosphoribosylamino)methylideneamino] Imidazole-4-Carboxamide Isomerase (APG10)
    • Interleukin 10 (IL10)
    • Interleukin 8 (IL8)
    • Interleukin 1, beta (IL1B)
    • Prolactin (PRL)
    • Adenosylhomocysteinase (AHCY)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Ferrochelatase, HEMH (HEMH)
    • Thymidylate Synthase (THYA)
    • Programmed Cell Death 1 (PDCD1)
    • SARS-CoV-2 Spike S1
    • Thymidine Kinase 1, Soluble (TK1)
    • Uracil Phosphoribosyltransferase (UPP)
    • beta-2-Microglobulin (B2M)
    • Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4)
    • Insulin-Like Growth Factor 1 (IGF1)
  • Application
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Crystallization (Crys)
  • Reactivity
    • Human
  • Images available
  • Host
    • Escherichia coli (E. coli)
  • Binding Specificity
    • AA 1-139
    • AA 1-154
  • Conjugate
    • Un-conjugated
    • His tag
  • Protein Type
    • Recombinant
  • Format
    • Liquid
  • Grade
    • Crystallography grade

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) Protein Profile

Protein Summary

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.

Gene names and symbols associated with VHLL

  • VHL like (VHLL) antibody
  • VHLP antibody
  • VLP antibody

Protein level used designations for VHLL

VHL pseudogene , VHL-like protein , von Hippel-Lindau-like protein

391104 Homo sapiens

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