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Von Hippel-Lindau Tumor Suppressor-Like Proteins

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation.

4 results:

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-139) protein (His tag) Protein

VHLL Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3075289
$6,041.45
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Delivery in 30 to 35 Business Days

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) protein (His tag) Protein

VHLL Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD
Catalog No. ABIN2735385
$302.50
Plus shipping costs $45.00 and $24.00 dry ice
50 μg
local_shipping Shipping to: United States
Will be delivered in 11 Business Days

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-154) protein (His tag) Protein

VHLL Origin: Human Recombinant > 95.0 % as determined by SDS-PAGE.
Catalog No. ABIN620853
$256.30
Plus shipping costs $45.00
50 μg (More quantities available)
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) Protein Protein

VHLL Origin: Human Recombinant
Catalog No. ABIN1068513
$285.21
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Will be delivered in 6 Business Days
  • Type Protein
    • Protein
  • Target Von Hippel-Lindau Tumor Suppressor-Like (VHLL)
    • Von Hippel-Lindau Tumor Suppressor-Like (VHLL)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Thymidylate Kinase (Tmk)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Lipoyl synthase lipA
    • Growth Hormone 1 (GH1)
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Epidermal Growth Factor (EGF)
    • Interleukin 8 (IL8)
    • Leptin (LEP)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • Hemoglobin, alpha 1 (HBA1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • phosphatidylserine Decarboxylase (PISD)
    • Interleukin 1 alpha (IL1A)
    • CD40 Ligand (CD40LG)
    • Prolactin (PRL)
    • Interleukin 13 (IL13)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Albumin (ALB)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Porphobilinogen Deaminase (HEMC)
    • Interleukin 15 (IL15)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • beta-2-Microglobulin (B2M)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Gp120
    • Interleukin 33 (IL33)
    • SARS-CoV-2 Spike S1
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
    • Adiponectin (ADIPOQ)
  • Application
    • Antibody Production (AbP)
    • ELISA
    • Functional Studies (Func)
    • Protein Interaction (PI)
    • SDS-PAGE (SDS)
    • Standard (STD)
    • Western Blotting (WB)
    • Crystallization (Crys)
  • Reactivity
    • Human
  • Images available
  • Host
    • Escherichia coli (E. coli)
  • Binding Specificity
    • AA 1-139
    • AA 1-154
  • Conjugate
    • Un-conjugated
    • His tag
  • Protein Type
    • Recombinant
  • Format
    • Liquid

Von Hippel-Lindau Tumor Suppressor-Like (VHLL) Protein Profile

Protein Summary

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.

Gene names and symbols associated with VHLL

  • VHL like (VHLL) antibody
  • VHLP antibody
  • VLP antibody

Protein level used designations for VHLL

VHL pseudogene , VHL-like protein , von Hippel-Lindau-like protein

GENE ID SPECIES
391104 Homo sapiens

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