Von Hippel-Lindau Tumor Suppressor-Like Proteins (VHLL)

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation.

list all proteins Gene Name GeneID UniProt
Human VHLL VHLL 391104 Q6RSH7
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Top Von Hippel-Lindau Tumor Suppressor-Like Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
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Human His tag   50 μg Log in to see 6 to 8 Days
$256.30
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Von Hippel-Lindau Tumor Suppressor-Like (VHLL) Protein Profile

Protein Summary

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.

Gene names and symbols associated with VHLL

  • VHL like (VHLL)
  • VHLP protein
  • VLP protein

Protein level used designations for VHLL

VHL pseudogene , VHL-like protein , von Hippel-Lindau-like protein

GENE ID SPECIES
391104 Homo sapiens
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