anti-WAP Four-Disulfide Core Domain 2 (WFDC2) Antibodies

WFDC2 encodes a protein that is a member of the WFDC domain family. Additionally we are shipping WFDC2 Proteins (26) and WFDC2 Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WFDC2 10406 Q14508
WFDC2 67701 Q9DAU7
WFDC2 286888 Q8CHN3
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top anti-WFDC2 Antibodies at

Showing 10 out of 188 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of HE4 using anti-HE4 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: rat testis tissue lysates,  Lane 2: rat brain tissue lysates, Lane 3: rat thymus tissue lysates, Lane 4: mouse testis tissue lysates, Lane 5: mouse brain tissue lysates, Lane 6: mouse thymus tissue lysates, Lane 7: mouse HEPA1-6 whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HE4 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4℃, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HE4 at approximately 19KD. The expected band size for HE4 is at 13KD. IHC analysis of HE4 using anti-HE4 antibody .HE4 was detected in paraffin-embedded section of mouse lung tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-HE4 Antibody  overnight at 4℃. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37℃. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC (p), WB IF analysis of human ovarian cancer tissue using HE4 antibody (dilution of primary antibody at 1:100) Immunohistochemical staining of paraffin embedded human ovarian cancer tissue using HE4 antibody (primary antibody at 1:100) 100 μg 10 to 15 Days
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of HE4 expression in 22RV1 whole cell lysates ( Lane 1). HE4 at 25KD was detected using rabbit anti- HE4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA 0.1 mg 2 to 3 Days
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
Dog Goat Un-conjugated EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human WFDC2 with C-terminal MYC tag probed with AP22455PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22455PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg 6 to 8 Days
Human Mouse Un-conjugated WB 100 μL 11 to 14 Days

Top referenced anti-WFDC2 Antibodies

  1. Human Monoclonal WFDC2 Primary Antibody for ELISA, WB - ABIN564522 : Yuan, Duan, Yang, Luo, Xi: Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance. in International journal of nanomedicine 2012 (PubMed)

  2. Human Polyclonal WFDC2 Primary Antibody for ELISA, WB - ABIN4276002 : Huhtinen, Suvitie, Hiissa, Junnila, Huvila, Kujari, Setälä, Härkki, Jalkanen, Fraser, Mäkinen, Auranen, Poutanen, Perheentupa: Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. in British journal of cancer 2009 (PubMed)

More Antibodies against WFDC2 Interaction Partners

Human WAP Four-Disulfide Core Domain 2 (WFDC2) interaction partners

  1. Higher serum levels of HE4 predict poor prognosis in non-small cell lung carcinoma patients, especially in patients with adenocarcinoma.

  2. High HE4 expression is associated with Ovarian Masses.

  3. WFDC2 is highly expressed in lung adenocarcinoma tissues with the anti-tumor immunosuppressive effect, which can significantly prolong overall survival of lung adenocarcinoma patients

  4. HE4, CA125, and CA72-4 are expressed differently and may be used to predict postoperative recurrence of ovarian cancer

  5. Detection of HE4 is conducive to the diagnosis and prediction of recurrence of epithelial ovarian cancer (EOC), and HE4 in high concentration suggests poor prognosis

  6. The expression of WFDC2 in ovarian cancer tissues is high, and is significantly associated with the prognosis survival in patients with ovarian cancer.

  7. these findings show that HE4 enhances ovarian cancer tumorigenesis by compromising osteopontin-mediated T cell activation

  8. HE4 has an important role in the diagnosis of epithelial ovarian cancer and a promising role in endometrial cancer (endometrioid histology).

  9. HE4 is a biomarker for ovarian cancer (systematic review and meta-analysis)

  10. These results may be commented as HE4 expression rises in patients with HER2/neu amplification.

  11. Serum HE4 with its high specificity is useful in ruling out ovarian malignancy especially among the premenopausal women and Risk of Ovarian Malignancy Algorithm (ROMA)which is the combination of both serum CA 125 and HE4, appears to be an all-rounder with overall good sensitivity and specificity especially among the postmenopausal women.

  12. CA125 appears the most reliable biomarker for OC monitoring, whereas HE4 contributes additional information only in a minority of cases

  13. level of HE4 might predict chemoresistance and the possibility of ascites formation. The determination of the expression of HE4 alone or combined with CA125 levels in both serum and ascites in ovarian cancer patients with ascites may have important significance for guiding and improving the treatment

  14. Elevated serum HE4 in SLE patients is significantly associated with a higher risk of incidence for lupus nephritis (LN), and may be a useful predictor for developing LN.

  15. HE4 has the potential to be used as a novel clinical biomarker for evaluating kidney function and predicting renal fibrosis in kidney transplant recipients

  16. A panel of three tumor markers CYFRA 21.1, HE4 and ProGRP may play a role for discriminating LC from benign lung disease and subtyping as SCLC.

  17. Serum Smac expression level was significantly lower in the EAOC group than in the control group and benign ovarian tumor group (P< 0.05), while HE4 and CA125 expression levels were significantly higher in the EAOC group than the other two groups.

  18. This study demonstrated that altered expression of HE4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between HE4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.

  19. High serum HE4 level is associated with epithelial ovarian cancer.

  20. Use of HE4 instead of CA125 did not significantly improve diagnostic performance of risk of malignancy indices 1-4 in patients with an adnexal mass

Mouse (Murine) WAP Four-Disulfide Core Domain 2 (WFDC2) interaction partners

  1. Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting high density lipoprotein levels

WFDC2 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Gene names and symbols associated with WFDC2

  • WAP four-disulfide core domain 2 (WFDC2) antibody
  • WAP four-disulfide core domain 2 (wfdc2) antibody
  • WAP four-disulfide core domain 2 (Wfdc2) antibody
  • 1600023A02Rik antibody
  • BE-20 antibody
  • CE4 antibody
  • dJ461P17.6 antibody
  • EDDM4 antibody
  • HE4 antibody
  • re4 antibody
  • si:ch211-153a8.3 antibody
  • WAP5 antibody
  • WFDC2 antibody
  • WFDC3 antibody

Protein level used designations for WFDC2

WAP four-disulfide core domain 2 , WAP four-disulfide core domain 3 , WAP four-disulfide core domain protein 2 , WAP domain containing protein HE4-V4 , epididymal protein 4 , epididymal secretory protein E4 , epididymis-specific, whey-acidic protein type, four-disulfide core , major epididymis-specific protein E4 , putative protease inhibitor WAP5 , WAP domain-containing protein HE4 , epididymal secretory protein 4 , epididymal protein BE-20

419300 Gallus gallus
458283 Pan troglodytes
618044 Bos taurus
100074492 Ornithorhynchus anatinus
556600 Danio rerio
396987 Sus scrofa
10406 Homo sapiens
67701 Mus musculus
286888 Rattus norvegicus
403919 Canis lupus familiaris
100009206 Oryctolagus cuniculus
Selected quality suppliers for anti-WFDC2 (WFDC2) Antibodies
Did you look for something else?