anti-WD Repeat Domain 48 (WDR48) Antibodies

Regulator of deubiquitinating complexes. Additionally we are shipping WDR48 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WDR48 57599 Q8TAF3
WDR48 67561 Q8BH57
WDR48    
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Top anti-WDR48 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB WDR48 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the WDR48 antibody detected the WDR48 protein (arrow). WDR48 antibody (C-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the WDR48 antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB WDR48 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WDR48 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. WDR48 Antibody (C-term) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the WDR48 antibody detected the WDR48 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody  - Staining of human testis shows moderate to strong positivity. Immunocytochemistry/Immunofluorescence: UAF1/WDR48 Antibody  - Staining of human cell line A-431 shows localization to vesicles. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using WDR48 antibody. Immunohistochemistry of paraffin-embedded rat liver using WDR48 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using WDR48 antibody (ABIN5974731) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat liver using WDR48 antibody (ABIN5974731) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescent staining of human cell line A-431 with WDR48 polyclonal antibody  at 1-4 ug/mL dilution shows positivity in vesicles. Immunohistochemical staining of human colon with WDR48 polyclonal antibody  shows strong cytoplasmic positivity in glandular cells at 1:20-1:50 dilution. 100 μL Log in to see 11 to 12 Days
$460.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 11 to 18 Days
$369.55
Details
Human Rabbit Un-conjugated FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$594.00
Details
Human Rabbit FITC FACS, IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details

WDR48 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human


, , , , ,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-WDR48 Antibodies

  1. Human Polyclonal WDR48 Primary Antibody for ICC, IF - ABIN4363861 : Ohashi, Holthaus, Calderwood, Lai, Krastins, Sarracino, Johannsen: The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. in PLoS pathogens 2015 (PubMed)

More Antibodies against WDR48 Interaction Partners

Human WD Repeat Domain 48 (WDR48) interaction partners

  1. There is evidence that USP1 (show USP1 Antibodies)/WDR48 complex promotes cancer stem cell conservation and regulation of DNA damage repair. [REVIEW]

  2. Our results highlight the interfaces essential for regulation of USP12 (show USP12 Antibodies) activity and show a conserved second binding of UAF1 which could be important for regulatory functions independent of USP12 (show USP12 Antibodies) activity.

  3. These results outline a novel mechanism for the control of TBK1 (show TBK1 Antibodies) activity and suggest USP1 (show USP1 Antibodies)-UAF1 complex as a potential target for the prevention of viral diseases.

  4. UAF1 and WDR20 (show WDR20 Antibodies) interact with USP12 (show USP12 Antibodies) at two distinct sites far from its catalytic center, allosterically activating the enzyme.

  5. USP1 (show USP1 Antibodies)-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 (show FANCD2 Antibodies) deubiquitination, as well as by interacting with RAD51AP1 (show RAD51AP1 Antibodies).

  6. analysis of the function and regulation of the USP1 (show USP1 Antibodies)-UAF1 complex

  7. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1 (show USP1 Antibodies), USP12 (show USP12 Antibodies) and USP46 (show USP46 Antibodies).

  8. our results reveal WDR48 and USP12 (show USP12 Antibodies) as novel PHLPP1 (show PHLPP1 Antibodies) regulators and potential suppressors of tumor cell survival.

  9. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1

  10. USP1 (show USP1 Antibodies) and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 (show USP1 Antibodies) nuclear localization signals.

WDR48 Antigen Profile

Protein Summary

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2\; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes (By similarity).

Gene names and symbols associated with WDR48

  • WD repeat domain 48 (WDR48) antibody
  • WD repeat domain 48 (Wdr48) antibody
  • 8430408H12Rik antibody
  • mKIAA1449 antibody
  • P80 antibody
  • UAF1 antibody

Protein level used designations for WDR48

USP1 associated factor 1 , USP1-associated factor 1 , WD repeat endosomal protein , WD repeat-containing protein 48

GENE ID SPECIES
57599 Homo sapiens
67561 Mus musculus
618860 Bos taurus
420427 Gallus gallus
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