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Regulator of deubiquitinating complexes. Additionally we are shipping WDR48 Proteins (4) and many more products for this protein.
Showing 10 out of 33 products:
Human Polyclonal WDR48 Primary Antibody for ICC, IF - ABIN4363861
Ohashi, Holthaus, Calderwood, Lai, Krastins, Sarracino, Johannsen: The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. in PLoS pathogens 2015
There is evidence that USP1 (show USP1 Antibodies)/WDR48 complex promotes cancer stem cell conservation and regulation of DNA damage repair. [REVIEW]
Our results highlight the interfaces essential for regulation of USP12 (show USP12 Antibodies) activity and show a conserved second binding of UAF1 which could be important for regulatory functions independent of USP12 (show USP12 Antibodies) activity.
These results outline a novel mechanism for the control of TBK1 (show TBK1 Antibodies) activity and suggest USP1 (show USP1 Antibodies)-UAF1 complex as a potential target for the prevention of viral diseases.
UAF1 and WDR20 (show WDR20 Antibodies) interact with USP12 (show USP12 Antibodies) at two distinct sites far from its catalytic center, allosterically activating the enzyme.
USP1 (show USP1 Antibodies)-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 (show FANCD2 Antibodies) deubiquitination, as well as by interacting with RAD51AP1 (show RAD51AP1 Antibodies).
analysis of the function and regulation of the USP1 (show USP1 Antibodies)-UAF1 complex
Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1 (show USP1 Antibodies), USP12 (show USP12 Antibodies) and USP46 (show USP46 Antibodies).
our results reveal WDR48 and USP12 (show USP12 Antibodies) as novel PHLPP1 (show PHLPP1 Antibodies) regulators and potential suppressors of tumor cell survival.
Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1
USP1 (show USP1 Antibodies) and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 (show USP1 Antibodies) nuclear localization signals.
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2\; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes (By similarity).
USP1 associated factor 1
, USP1-associated factor 1
, WD repeat endosomal protein
, WD repeat-containing protein 48