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The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Additionally we are shipping WW and C2 Domain Containing 1 Kits (12) and WW and C2 Domain Containing 1 Proteins (9) and many more products for this protein.
Showing 10 out of 55 products:
Human Polyclonal WWC1 Primary Antibody for ICC, IF - ABIN4328780
Tanaka, Osada, Fujii, Fukatsu, Hida, Horio, Kondo, Sato, Hasegawa, Tsujimura, Sekido: LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. in Oncogene 2015
elevated expression of Par3 (show F2RL2 Antibodies) promotes PCa (show FLVCR1 Antibodies) metastasis via KIBRA sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes.
Merlin (show NF2 Antibodies) and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.
Kibra, a binding partner of Pez (show PTPN14 Antibodies), stabilizes Pez (show PTPN14 Antibodies) via WW-PY/PPxY interaction.
Kibra regulates starvation-induced autophagy downstream of aPKC.
In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.
The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
Kibra functions as a tumor suppressor protein (show TP53 Antibodies) that regulates Hippo signaling in conjunction with Merlin (show NF2 Antibodies) and Expanded.
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Kibra predominantly acts in the Merlin (show NF2 Antibodies) branch upstream of the core kinase cascade to regulate Hippo signaling.
Data (including data from studies in knockout mice) suggest that KIBRA plays important role in regulating HPO (show GFER Antibodies) activity, YAP (show YAP1 Antibodies) signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA and YAP (show YAP1 Antibodies) plus phosphorylation of YAP (show YAP1 Antibodies) are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA = kidney/brain protein-KIBRA; HPO (show GFER Antibodies) = hepatopoietin protein (show GFER Antibodies); YAP (show YAP1 Antibodies) = Yes associated protein-1 (show YAP1 Antibodies))
the overall data in the present meta-analysis revealed a significant association of KIBRA polymorphism rs17070145 and risk of Alzheimer disease. [meta-analysis]
the study indicated that loss of WWC1 may contribute to podocyte apoptosis by inducing nuclear relocation of dendrin protein, which provided novel insight into the molecular events in podocyte apoptosis.
that APOE (show APOE Antibodies) and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults
In younger adults, no effects of KIBRA were found
Data show that promoter methylation is a major mechanism involved in KIBRA expression regulation. KIBRA expression levels are reduced in clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC) and alterations in the balance of KIBRA/SP1 (show PSG1 Antibodies) binding by promoter methylation may be involved in the onset and/or progression of ccRCC.
our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK (show MAPK1 Antibodies) signaling, a key pathway involved in memory and learning processes
we report for the first time that CRB3 (show CRB3 Antibodies) acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra and/or FRMD6 (show FRMD6 Antibodies), in mammary epithelial cells.
Ability to navigate in the wilderness benefits from episodic memory (KIBRA).
Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3 (show CELSR3 Antibodies)), NIPBL (show NIPBL Antibodies) (Nipped (show RPL38 Antibodies)-B-like), and FN1 (fibronectin 1 (show FN1 Antibodies)).
study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease
KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.
KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif
KIBRA functions in memory performance via interaction with PKMzeta.
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.
, lethal (3) neo42
, HBeAg-binding protein 3
, WW, C2 and coiled-coil domain containing 1
, kidney and brain protein
, protein KIBRA
, protein WWC1
, WW domain-containing protein 1