YY1 Transcription Factor Proteins (YY1)

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. Additionally we are shipping YY1 Transcription Factor Antibodies (140) and YY1 Transcription Factor Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
YY1 7528 P25490
YY1 22632 Q00899
Rat YY1 YY1 24919  
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Top YY1 Transcription Factor Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
$492.31
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Human DYKDDDDK Tag   10 μg Log in to see 1 to 2 Days
$460.83
Details

YY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for YY1 Transcription Factor (YY1) Interaction Partners

Xenopus laevis YY1 Transcription Factor (YY1) interaction partners

  1. YY1 is essential for Xenopus development in neural ectoderm differentiation, neural crest specification and directing neural crest mesenchyme formation by blocking slug

  2. Yin Yang 1 transcription factor assembly into messenger ribonucleoprotein particles requires direct RNA binding activity

  3. Results show that the YY1-RNA interaction is highly stable, and that YY1 possesses the ability to interact with structurally divergent RNA substrates.

Zebrafish YY1 Transcription Factor (YY1) interaction partners

  1. Study reveals for the first time that miR-7a1 functions to regulate molecular pathways involved in NAFLD/NASH phenotypes in zebrafish models. YY1b is a novel downstream target of miR-7a1 and is beneficial for lipid anabolism in zebrafish.

  2. results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development

  3. YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.

  4. Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox pathway.

Human YY1 Transcription Factor (YY1) interaction partners

  1. Aurora A phosphorylation of YY1 during mitosis inactivates its DNA binding activity.

  2. The YY1 p.T372R heterozygous mutation was found in 2 of 23 sporadic insulinoma samples, but not in the corresponding RNA of the two mutation-positive samples. YY1 mRNA was abundantly expressed in the tumors with the mutation.

  3. Studies demonstrate that miR-500a-5p functions as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis, which contributes to the development of and provides new potential candidates for CRC therapy.

  4. we discuss the correlation between YY1 expression and clinical outcomes and therapeutic potential of YY1 in cancer treatment. Based on this review, we conclude that YY1 is a bona fide inducer of cancer metastasis and can serve as a clinical biomarker and therapeutic target for cancer treatment.

  5. in this review, we focus on the role of YY1 in cancer biology, including its expression, function, regulation by other upstream factors, and some of its more significant downstream effectors.

  6. Our work shows for the first time that YY1 represses survivin transcription by physically interacting with the survivin promoter. Furthermore, YY1 appears to contribute to basal survivin transcriptional activity, indicating that disruption of its binding may in part contribute to survivin overexpression after cellular stress events including chemotherapy and radiotherapy.

  7. In this review, a general discussion is provided on the role of YY1 overexpression in cancer and the application of various inhibitors of YY1 activities and their potential as therapeutics.

  8. This review discusses the potential therapeutic targeting of an overexpressed transcription factor, Yin Yang 1 (YY1), which has been implicated in the development of epithelial-mesenchymal transition (EMT) and drug resistance. Several examples targeting YY1 in experimental models are presented.

  9. A summary is of the published studies on the expression levels of YY1 in human cancers and their potential cross-reactivities with YY2 is also provided. Well-documented monospecific antibodies to both YY1 and YY2 have to be developed and used when examining the expression levels of YY1 and YY2 in human cancers to elucidate the accurate relationship between them and clinical significance of each.

  10. Meta-analysis of YY1-DNA binding allowed us to observe that YY1's avidity to multiple binding sites is crucial in providing high-affinity specific sequence recognition. Alternatively, other trans-acting factors can modulate the YY1-DNA interaction and influence its outcome.

  11. deregulation of the epigenome is observed frequently in a variety of cancer types and is often correlated directly with advanced metastatic stages and poor prognosis. In this review, we address the current understanding of YY1 as a recruiter of epi-modifier molecules in the mechanism of aberrant regulation of target genes as a part of the metastatic cascade.

  12. In this review, we summarize and analyze recent findings about the regulation of YY1 at multiple levels. We emphasize the necessity for deeper insights into these regulatory mechanisms if YY1 is to find its way to the clinical setting.

  13. These data demonstrate that miR-584-3p directly targets the MMP-14 promoter to repress YY1-facilitated MMP-14 expression and inhibits the progression of gastric cancer.

  14. Study shows YAP/TAZ function as key nodes of multiple signaling pathways and play multiple regulatory roles in cancer cells especially in metabolic reprogramming. [review]

  15. miR186 reverses cisplatin resistance and inhibits the formation of the glioblastomainitiating cell phenotype by degrading YY1 in glioblastoma.

  16. both YY1 and E2A bind to E3' of the human Igkappa locus and regulate Igkappa expression through epigenetic modifications. The results also imply a novel mechanism by which YY1 contributes to antibody maturation by transiently inhibiting Igkappa expression in germinal center B cells.

  17. study identified NPCCAT1 as an oncogenic lncRNA which promotes nasopharyngeal carcinoma (NPC) progression via upregulating YY1, and suggested that lncRNA NPCCAT1 may be a promising therapeutic target for NPC.

  18. In conclusion, YY1 may play an important regulatory role in ATP6V1A expression with potential mechanistic and clinical implications in gastric cancer.

  19. Data show that MiR-147b targets the 3' untranslated region (3'UTR) of Yin Yang 1 (YY1).

  20. Results show that YY1 is phosphorylated by c-Abl kinase at tyrosine residue 254 and that this phosphorylation likely modulates its transcriptional activity.

Mouse (Murine) YY1 Transcription Factor (YY1) interaction partners

  1. this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAF complex.

  2. this study shows that YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation

  3. In this review, we summarize findings on the roles of YY1 in cell differentiation and tissue development, in particular in muscle, nerve, and immune cells/tissues.

  4. YY1 is mainly involved in controlling the transcriptional levels, but not the DNA methylation, of the Peg3 domain.

  5. A delicate and synergistical collaboration between YY1 and the master transcription factor NRF2 that functions to mobilize the cell's antioxidant machinery.

  6. this study shows that YY1 can control AID-mediated mutagenesis in mice

  7. YY1 was progressively up-regulated in BV2 microglial cells stimulated with lipopolysaccharide (LPS), which was dependent on the transactivation function of nuclear factor kappa B (NF-kappaB). Furthermore, YY1 knockdown notably inhibited LPS-induced the activation of NF-kappaB signaling and interleukin-6 (IL-6) expression in BV-2cells.

  8. The interaction of repressor proteins Trim28 and YY1 are involved in the silencing of Moloney murine leukemia virus.

  9. This study provides novel evidence for a role of miR-34c in inhibiting myoblasts proliferation by repressing YY1.

  10. These observations support a role for YY1 meditating and/or regulating the interaction of OCT4 and SOX2 at a posttranscriptional level.

  11. these results demonstrate that YY1 overexpression is sufficient to maintain a Cardiac Progenitor Cell phenotype.

  12. these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 and YY1 in NIH3T3 cells

  13. DNA binding domain of YY1 is necessary for X-chromosome inactivation in activated B cells, as ex-vivo YY1 deletion results in loss of inactive X (Xi) chromosome heterochromatin marks and up-regulation of X-linked genes.

  14. Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine.

  15. regulates broad general processes throughout all stages of B-cell differentiation: normally activates genes involved in mitochondrial bioenergetics; normally down-regulates genes involved in transcription, mRNA splicing, NF-kappaB signaling pathways, the AP-1 transcription factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell proliferation

  16. Results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in germinal center (GCs) and between survival and death of GC B cells.

  17. YY1 is required for germinal center B cell development.

  18. Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter.

  19. this study shows that YY1 regulates the formation of terminal-effector CD8+ T cell fates

  20. that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis

YY1 Transcription Factor (YY1) Protein Profile

Protein Summary

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Gene names and symbols associated with YY1 Transcription Factor Proteins (YY1)

  • YY1 transcription factor L homeolog (yy1.L)
  • YY1 transcription factor b (yy1b)
  • YY1 transcription factor (YY1)
  • YY1 transcription factor (yy1)
  • transcriptional repressor protein YY1 (LOC100304682)
  • YY1 transcription factor S homeolog (yy1.S)
  • YY1 transcription factor (Yy1)
  • YY1 transcription factor a (yy1a)
  • YY2 transcription factor (YY2)
  • AW488674 protein
  • DELTA protein
  • fb59g10 protein
  • FIII protein
  • INO80S protein
  • LOC494431 protein
  • LOC100304682 protein
  • MGC83714 protein
  • NF-E1 protein
  • UCRBP protein
  • wu:fa16g07 protein
  • wu:fb59g10 protein
  • xyy1 protein
  • YIN-YANG-1 protein
  • yy1 protein
  • yy1-a protein
  • yy1l protein
  • zgc:64207 protein

Protein level used designations for YY1 Transcription Factor Proteins (YY1)

YY1 transcription factor , YY1 transcription factor, like , transcription factor YY1 , Yin Yang 1 , INO80 complex subunit S , YY-1 , Yin and Yang 1 protein , delta transcription factor , transcriptional repressor protein YY1 , GLI-Krupple related protein , UCR-motif DNA-binding protein , UCRBP transcription factor , yin and yang 1

GENE ID SPECIES
394372 Xenopus laevis
406394 Danio rerio
453159 Pan troglodytes
494431 Ovis aries
100126440 Xenopus (Silurana) tropicalis
100304682 Ictalurus punctatus
100022685 Monodelphis domestica
100229529 Taeniopygia guttata
447228 Xenopus laevis
7528 Homo sapiens
611171 Canis lupus familiaris
534353 Bos taurus
22632 Mus musculus
24919 Rattus norvegicus
322397 Danio rerio
423455 Gallus gallus
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