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ZBP1 encodes a Z-DNA binding protein. Additionally we are shipping Z-DNA Binding Protein 1 Antibodies (74) and Z-DNA Binding Protein 1 Kits (14) and many more products for this protein.
Showing 7 out of 10 products:
There is a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression in preeclampsia.
Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host.
DAI could function as a DNA sensor and a regulator in DNA-induced macrophage M2b polarization and lupus nephritis.
Collectively, these results demonstrate that DAI can suppress HSV-1 growth independent of DNA sensing through mechanisms involving suppression of viral genomes and regulation of ICP0.
these data indicate that ZBP1 (show IGF2BP1 Proteins) may function as an adapter to export the Ro/Y3 RNA complex from nuclei.
Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B (show TDO2 Proteins)- and Z-DNAs.
hZbeta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism.
These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-kappaB (show NFKB1 Proteins) pathway.
identify ZBP1 (show IGF2BP1 Proteins) as being essential for IRF3 (show IRF3 Proteins) activation and interferon beta (show IFNB1 Proteins) expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon (show IFNA Proteins) transcription and secretion.
Z-DNA binding activities of two Zalpha domains in the human ZBP1 (show IGF2BP1 Proteins), hZalpha(ZBP1 (show IGF2BP1 Proteins)) and hZbeta(ZBP1 (show IGF2BP1 Proteins))were characterized.
Murine cytomegalovirus IE3-dependent transcription from the viral genome plays a crucial role in activating DAI/ZBP1-dependent necroptosis. This implicates RNA transcripts generated by a large double-stranded DNA virus as a biologically relevant ligand for DAI/ZBP1 during natural viral infection.
activation requires RIG-I (show DDX58 Proteins) signaling, ubiquitination, and vRNP sensing to trigger activation of programmed cell death pathways during influenza A virus infection
These results identify DAI as a link between influenza A virus replication and RIPK3 (show RIPK3 Proteins) activation and implicate DAI as a sensor of RNA viruses.
findings identify ZBP1 as a critical mediator of inflammation beyond its previously known role in antiviral defence and suggest that ZBP1 might be implicated in the pathogenesis of necroptosis-associated inflammatory diseases
findings indicate that the RHIM of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development
DAI as an important cytosolic DNA sensor, is responsible for the recognition of A/T or G/C-rich DNA derived from DNA virus.
Disruption of the in vivo interaction of KIF11 (show KIF11 Proteins) with ZBP1 delocalizes beta-actin (show ACTB Proteins) mRNA and affects cell migration.
Association of ribosomes and ZBP1 with the mRNA were anti-correlated both near the nucleus of primary fibroblasts and neurons and in peripheral cellular regions such as the leading edge of fibroblasts, therefore validating the hypothesis that ZBP1 spatially regulates beta-actin (show ACTB Proteins) mRNA localized translation.
DAI interacts with RIP3 to mediate virus-induced necrosis analogous to the RIP1 (show RALBP1 Proteins)-RIP3 complex controlling death receptor-induced necroptosis.
data support a direct role for ZBP1 in transport and translation of mRNA cargos in axonal regeneration in vitro and in vivo
These results indicate that DAI is an important immuno-regulator of the porcine innate immune system
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA-dependent activator of IFN-regulatory factors
, DNA-dependent activator of IRFs
, DNA-dependent activator of interferon regulatory factors
, Z-DNA-binding protein 1
, tumor stroma and activated macrophage protein DLM-1
, Z-DNA binding protein 1
, DNA-dependent activator of IFN-regulatory factor