ZBP1 Protein (His tag)
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- Target See all ZBP1 Proteins
- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ZBP1 protein is labelled with His tag.
- Purpose
- Recombinant Human ZBP1 Protein (His Tag)
- Sequence
- Met 1-Ser149
- Characteristics
- Recombinant Human Z-DNA Binding Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser149 is expressed with a 6His tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ZBP1 Protein
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Z-DNA Binding Protein 1 (ZBP1) (AA 1-149) protein (GST tag)
ZBP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Z-DNA Binding Protein 1 (ZBP1) (AA 2-100) protein (GST tag)ZBP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Z-DNA Binding Protein 1 (ZBP1) (AA 1-429) protein (Strep Tag)Crystallography grade ZBP1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Z-DNA Binding Protein 1 (ZBP1) (Transcript Variant 1) protein (His tag)ZBP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
- Alternative Name
- ZBP1 (ZBP1 Products)
- Synonyms
- C20orf183 Protein, DAI Protein, DLM-1 Protein, DLM1 Protein, 2010010H03Rik Protein, Dai Protein, Dlm1 Protein, mZaDLM Protein, ZBP1 Protein, Z-DNA binding protein 1 Protein, ZBP1 Protein, Zbp1 Protein
- Background
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Background: Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
Synonym: Z-DNA-Binding Protein 1, Tumor Stroma and Activated Macrophage Protein DLM, ZBP1, C20orf183, DLM1
- Molecular Weight
- 17.5 kDa
- UniProt
- Q9H171
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