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Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Additionally we are shipping ZCCHC6 Antibodies (6) and many more products for this protein.
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Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6 (show IL6 Proteins), CXCL1 (show CXCL1 Proteins), and CXCL5 (show CXCL5 Proteins). These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
The authors found that TUT4 (show ZCCHC11 Proteins)(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
Knockdown of 3'hExo (show ERI1 Proteins) also altered the uridylation of histone mRNAs, suggesting that TUT7 and 3'hExo (show ERI1 Proteins) function together in trimming and uridylating histone mRNAs
Study identified TUT4 (show ZCCHC11 Proteins) and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
Study identified TUT7, TUT4 (show ZCCHC11 Proteins), and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 (show LIN28A Proteins) uses two different TUTases to control let-7 expression .
Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation (By similarity).
PAP associated domain containing 6
, TUTase 7
, terminal uridylyltransferase 7
, zinc finger CCHC domain-containing protein 6