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Zmpste24 encodes a member of the peptidase M48A family. Additionally we are shipping Zinc Metalloproteinase, Ste24 Antibodies (126) and Zinc Metalloproteinase, Ste24 Kits (2) and many more products for this protein.
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ZMPSTE24 is a downstream effector of IFITM3 (show IFITM3 Proteins) and is important for interferon (show IFNA Proteins)-induced transmembrane antiviral activity.
ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.
This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase (show ECEL1 Proteins) that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy.
used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism
the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype.
results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated
ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA (show LMNA Proteins) mutations or PI treatments that could translate in early atherosclerosis at the clinical level.
Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.
complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.
miR (show MLXIP Proteins)-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.
we identified the abnormal lamin A (prelamin A), accompanied by a down-regulation of a lamin A processing enzyme (Zmpste24) in the kidney of the GMF transgenic mice
In Zmpste24(-/-) mice, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase, Mof (show KAT8 Proteins), to the nuclear matrix.
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype
the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna (show LMNA Proteins)
Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice
Zmpste24 deficiency elicits a stress signalling pathway that is evidenced by a marked upregulation of p53 (show TP53 Proteins) target genes, and accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
, zinc metallopeptidase (STE24 homolog)
, zinc metallopeptidase STE24 homolog
, zinc metalloproteinase STE24 homolog
, CAAX prenyl protease 1 homolog
, STE24 endopeptidase
, zinc metalloproteinase
, zinc metallopeptidase STE24
, CAAX prenyl protease 1 homolog-like
, farnesylated proteins-converting enzyme 1
, prenyl protein-specific endoprotease 1
, zinc metalloproteinase Ste24 homolog
, zinc metallopeptidase, STE24 homolog
, zinc metalloproteinase, STE24 homolog
, farnesylated-proteins converting enzyme 1
, zinc metalloproteinase (STE24 homolog, yeast)