Zinc Metalloproteinase, Ste24 Proteins (Zmpste24)

Zmpste24 encodes a member of the peptidase M48A family. Additionally we are shipping Zinc Metalloproteinase, Ste24 Antibodies (110) and Zinc Metalloproteinase, Ste24 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Zmpste24 10269 O75844
Zmpste24 313564  
Zmpste24 230709 Q80W54
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Top Zinc Metalloproteinase, Ste24 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   5 applications 1 to 2 Days

Zmpste24 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)
Mouse (Murine) ,

More Proteins for Zinc Metalloproteinase, Ste24 (Zmpste24) Interaction Partners

Human Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. ZMPSTE24-dependent cleavage of prelamin A and the eight known disease-associated ZMPSTE24 missense mutations, were examined.

  2. ZMPSTE24 is a downstream effector of IFITM3 and is important for interferon-induced transmembrane antiviral activity.

  3. ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.

  4. This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy.

  5. used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism

  6. the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype.

  7. results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated

  8. ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA mutations or PI treatments that could translate in early atherosclerosis at the clinical level.

  9. Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.

  10. complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.

  11. miR-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.

  12. These data implicate copper as an important factor in promoting prostate cancer cell invasion and indicate that the selective posttranslational activation of ZMP-mediated protein shedding might play a role in this process.

  13. Laminopathy-associated mutations predicted to reduce ZMPSTE24 activity map to the zinc metalloprotease peptide-binding site and to the bottom of the chamber.

  14. Characterization of disease causing mutations in the ZMPSTE24 gene, residual proteolytic activity correlates with disease severity.

  15. A report of a novel and a previously reported homozygous null mutation in ZMPSTE24 in two newborns with restrictive dermopathy.

  16. Three of 87 patients with metabolic syndrome carry a heterozygous mutation in LMNA or in ZMPSTE24.

  17. In patients with mandibuloacral dysplasia due to ZMPSTE24 mutations, the onset of disease manifestations such as thin skin and micrognathia occurs as early as 5 months of age.

  18. Data show that mandibuloacral dysplasia associated with ZMPSTE24 mutations has a more severe phenotype than that associated with lamin A mutations.

  19. ZMPSTE24 mutations are associated with dermopathy.

  20. study reports on two brothers affected with restrictive dermopathy; compound heterozygous frameshifting mutations were identified in exon 1 (c.50delA) and exon 5 (c.584_585delAT) of the ZMPSTE24 gene

Mouse (Murine) Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro.

  2. ZMPSTE24 is a downstream effector of IFITM3 and is important for interferon-induced transmembrane antiviral activity.

  3. ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.

  4. we identified the abnormal lamin A (prelamin A), accompanied by a down-regulation of a lamin A processing enzyme (Zmpste24) in the kidney of the GMF transgenic mice

  5. In Zmpste24(-/-) mice, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase, Mof, to the nuclear matrix.

  6. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

  7. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

  8. Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype

  9. the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna

  10. Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice

  11. Zmpste24 deficiency elicits a stress signalling pathway that is evidenced by a marked upregulation of p53 target genes, and accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level

  12. darunavir does not inhibit the biochemical activity of ZMPSTE24, nor does it lead to an accumulation of farnesyl-prelamin A in cells.

  13. Zmpste24-null mice show accelerated aging and exhibit an extensive basal activation of autophagy.

Zinc Metalloproteinase, Ste24 (Zmpste24) Protein Profile

Protein Summary

This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.

Gene names and symbols associated with Zmpste24

  • zinc metallopeptidase STE24 (ZMPSTE24)
  • zinc metallopeptidase STE24 L homeolog (zmpste24.L)
  • zinc metallopeptidase STE24 (zmpste24)
  • CAAX prenyl protease (zmpste24)
  • Peptidase family M48 family protein (ATSTE24)
  • zinc metallopeptidase STE24 (Zmpste24)
  • zinc metallopeptidase, STE24 (Zmpste24)
  • zinc metallopeptidase, STE24 homolog (zmpste24)
  • A530043O15Rik protein
  • D030046F19 protein
  • DDBDRAFT_0189115 protein
  • DDBDRAFT_0237846 protein
  • DDB_0189115 protein
  • DDB_0237846 protein
  • F2N1.21 protein
  • F2N1_21 protein
  • Face-1 protein
  • FACE1 protein
  • fi45a02 protein
  • HGPS protein
  • MADB protein
  • PRO1 protein
  • STE24 protein
  • Ste24p protein
  • wu:fi45a02 protein
  • zgc:55655 protein

Protein level used designations for Zmpste24

zinc metallopeptidase (STE24 homolog, S. cerevisiae) , zinc metallopeptidase (STE24 homolog) , zinc metallopeptidase STE24 homolog , zinc metalloproteinase STE24 homolog , CAAX prenyl protease 1 homolog , STE24 endopeptidase , zinc metalloproteinase , zinc metallopeptidase STE24 , CAAX prenyl protease 1 homolog-like , farnesylated proteins-converting enzyme 1 , prenyl protein-specific endoprotease 1 , zinc metalloproteinase Ste24 homolog , zinc metallopeptidase, STE24 homolog , zinc metalloproteinase, STE24 homolog , farnesylated-proteins converting enzyme 1 , zinc metalloproteinase (STE24 homolog, yeast)

419572 Gallus gallus
447784 Xenopus laevis
456790 Pan troglodytes
482460 Canis lupus familiaris
550009 Xenopus (Silurana) tropicalis
693765 Macaca mulatta
8627861 Dictyostelium discoideum AX4
100032108 Monodelphis domestica
100339077 Oryctolagus cuniculus
100404786 Callithrix jacchus
100445390 Pongo abelii
100475834 Ailuropoda melanoleuca
100557771 Anolis carolinensis
100580430 Nomascus leucogenys
828209 Arabidopsis thaliana
538104 Bos taurus
10269 Homo sapiens
313564 Rattus norvegicus
230709 Mus musculus
334380 Danio rerio
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