anti-gamma-Glutamyl Carboxylase (GGCX) Antibodies

GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Additionally we are shipping GGCX Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GGCX 2677 P38435
GGCX 56316 Q9QYC7
GGCX 81716 O88496
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Top anti-GGCX Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-GGCX Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  MCF7 cell lysate. GGCX is strongly supported by BioGPS gene expression data to be expressed in MCF7 Host:  Rabbit  Target Name:  GGCX  Sample Type:  Jurkat  Antibody Dilution:  1.0ug/ml  GGCX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed and paraffin embedded human liver tissue reacted with GGCX Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of GGCX Antibody (Center) in 293 cell line lysates (35ug/lane). This demonstrates the GGCX antibody detected the GGCX protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB GGCX Antibody (Center) (ABIN655069) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IP, WB   100 μg Log in to see 1 to 2 Days
$462.69
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit FITC ELISA, IHC, IP, WB   100 μg Log in to see 1 to 2 Days
$534.62
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GGCX antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Dog Goat Un-conjugated EIA, WB   0.1 mg Log in to see 4 to 8 Days
$462.00
Details
Human Goat Un-conjugated ELISA, IHC, WB Western Blot: GGCX Antibody [NBP1-51964] - Analysis of GGCX in Human Muscle lysate (35ug protein in RIPA buffer) using NBP1-51964 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. Immunohistochemistry-Paraffin: GGCX Antibody  - Staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$488.73
Details

Top referenced anti-GGCX Antibodies

  1. Human Polyclonal GGCX Primary Antibody for ELISA, IHC - ABIN4314074 : Li, Grange, Armstrong, Whelan, Hurley, Rishavy, Hallgren, Berkner, Schurgers, Jiang, Uitto: Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. in The Journal of investigative dermatology 2009 (PubMed)

More Antibodies against GGCX Interaction Partners

Human gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. The risk for ischemic atherothrombotic stroke in patients with the gamma-glutamyl carboxylase T/T genotype was higher than in major C-allele carriers.

  2. unlike the traditional in vitro GGCX activity assay, allows us to assess the functionality of GGCX using its natural protein substrates in a cellular milieu

  3. 2 causative GGCX mutations ( c.1889-6G>A and c.1657delA) from the first reported clinical case of a VKCFD patient. The intronic mutation c.1889-6G>A affects GGCX splicing. Functional characterization of these 2 mutations suggests that truncation of GGCX from its C-terminus affects not only substrate binding but also protein stability.

  4. impact of CYP4F2, ABCB1, and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation

  5. this systematic review suggests that there indeed may be genotype-phenotype correlations for GGCX-related phenotypes, which can guide patient counseling and management.

  6. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS rs7856096, and STX1B rs4889606.

  7. GGCX c.2084+45G polymorphisms has a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe.

  8. Detected are ten mutations in the gamma-glutamyl carboxylase gene in patients with hereditary deficiency of vitamin K-dependent coagulation factors.

  9. The allele frequency for GGCX 12970 C > G is 1.43 in north Indians and did not have a significant bearing on the maintenance dose of acenocoumarol oral anticoagulant in cardiac valve replacement patients.

  10. GGCX mutation found in families with pseudoxanthoma elasticum with retinitis pigmentosa and cutis laxa.

  11. These findings indicate that individuals carrying the CYP2C19 rs3814637CC or CYP2C9 rs1057910AA or GGCX rs699664AA genotype needed higher warfarin doses in the Chinese population.

  12. In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in the gamma-glutamyl carboxylase gene rs259251 loci required significantly higher warfarin dose than those with CC genotype.

  13. evaluation of urinary Gla excretion in relation with apo E genotype

  14. study demonstrated the effects of SNP (974G>A) in the GGCX gene on the correlation between dietary vitamin K intake and gamma-carboxylation of serum osteocalcin

  15. there may be no significant association between the low activity and mutation of GGCX in calcium oxalate urolithiasis

  16. Quantitative PCR assays for VKORC1, CYP4F2, GGCX and CALU identified two copies in all populations.

  17. GGCX polymorphism appeared to have an influence over the reduction of undercarboxylated osteocalcin, especially in older women (age >/=65).

  18. no association between haplotypes and venous thrombosis

  19. no effects of genetic variants on maintenance warfarin dose in a multi-ethnic Asian population

  20. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.

Mouse (Murine) gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. GGCX in osteoblasts functions to prevent abnormal mineralization in bone formation.

  2. findings suggest that GGCX expressed in osteoblasts is critical for the maintenance of blood glucose and WAT

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  4. Ggcx(Deltaliver/Deltaliver) mice displayed bleeding diathesis.

  5. Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate substrate binding on the structure and function of {gamma}-glutamyl carboxylase.

  6. These findings suggest a role for both the GGCX gene and the genetic background as well as dietary factors in modulating the phenotypic severity of Pseudoxanthoma elasticum caused by loss-of-function mutations in ABCC6.

  7. Analysis of a Ggcx(+/-) intercross revealed a partial developmental block with only 50% of expected Ggcx(-/-) offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage

GGCX Antigen Profile

Protein Summary

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GGCX

  • gamma-glutamyl carboxylase (GGCX) antibody
  • gamma-glutamyl carboxylase (ggcx) antibody
  • gamma-glutamyl carboxylase (GC) antibody
  • gamma-glutamyl carboxylase (sce5891) antibody
  • gamma-glutamyl carboxylase L homeolog (ggcx.L) antibody
  • gamma-glutamyl carboxylase (Ggcx) antibody
  • cb751 antibody
  • CG13927 antibody
  • dgammaC antibody
  • dGC antibody
  • Dmel\\CG13927 antibody
  • gammaC antibody
  • GGC antibody
  • ggcx antibody
  • si:ch1073-230p18.3 antibody
  • VKCFD1 antibody
  • zgc:158736 antibody

Protein level used designations for GGCX

gamma-glutamyl carboxylase , vitamin K-dependent gamma-carboxylase , peptidyl-glutamate 4-carboxylase , vitamin K gamma glutamyl carboxylase , CG13927-PA , CG13927-PB , GC-PA , GC-PB , gamma-glutamyl-carboxylase , gamma glutamyl carboxylase

GENE ID SPECIES
459364 Pan troglodytes
557240 Danio rerio
695628 Macaca mulatta
780874 Ciona intestinalis
100144666 Xenopus (Silurana) tropicalis
100171564 Pongo abelii
38194 Drosophila melanogaster
5810488 Sorangium cellulosum So ce56
444473 Xenopus laevis
2677 Homo sapiens
281190 Bos taurus
56316 Mus musculus
81716 Rattus norvegicus
475769 Canis lupus familiaris
443129 Ovis aries
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