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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis.
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Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)
Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.
cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells
Tumor necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.
subcellular localization and function of polycystin-2 (show PKD2 Proteins) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Proteins)/endosomal system
the phosphorylation state of the calnexin (show CANX Proteins) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane
Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Proteins) cooperates with 14-3-3 (show YWHAQ Proteins) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.
PACS-2 coordinates p53 (show TP53 Proteins)/p21- dependent cell cycle arrest with NF-kappaB (show NFKB1 Proteins)/Bcl-xL (show BCL2L1 Proteins)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.
CS-2 (show MYOZ1 Proteins) traffics to the nucleus where it regulates SIRT1 (show SIRT1 Proteins)-mediated p53 (show TP53 Proteins) deacetylation. PACS-2 binds SIRT1 (show SIRT1 Proteins) in vitro and directly inhibits SIRT1 (show SIRT1 Proteins)-catalyzed p53 (show TP53 Proteins) deacetylation.
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.