phosphofurin Acidic Cluster Sorting Protein 2 Proteins (PACS2)

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis.

list all proteins Gene Name GeneID UniProt
Human PACS2 PACS2 23241 Q86VP3
Mouse PACS2 PACS2 217893  
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Top PACS2 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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More Proteins for phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Interaction Partners

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)

  2. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

  3. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

  4. Tumor necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

  5. subcellular localization and function of polycystin-2 (show PKD2 Proteins) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2

  6. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

  7. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Proteins)/endosomal system

  8. the phosphorylation state of the calnexin (show CANX Proteins) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

  9. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Proteins) cooperates with 14-3-3 (show YWHAQ Proteins) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. PACS-2 coordinates p53 (show TP53 Proteins)/p21- dependent cell cycle arrest with NF-kappaB (show NFKB1 Proteins)/Bcl-xL (show BCL2L1 Proteins)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.

  2. CS-2 (show MYOZ1 Proteins) traffics to the nucleus where it regulates SIRT1 (show SIRT1 Proteins)-mediated p53 (show TP53 Proteins) deacetylation. PACS-2 binds SIRT1 (show SIRT1 Proteins) in vitro and directly inhibits SIRT1 (show SIRT1 Proteins)-catalyzed p53 (show TP53 Proteins) deacetylation.

  3. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Proteins)/endosomal system

  4. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Proteins) cooperates with 14-3-3 (show YWHAQ Proteins) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

PACS2 Protein Profile

Protein Summary

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Gene names and symbols associated with PACS2

  • phosphofurin acidic cluster sorting protein 2 (PACS2)
  • phosphofurin acidic cluster sorting protein 2 (Pacs2)
  • 6720425G15Rik protein
  • AW208651 protein
  • AW489976 protein
  • E230011J22 protein
  • mKIAA0602 protein
  • PACS-2 protein
  • Pacs1l protein

Protein level used designations for PACS2

PACS1-like protein , PACS-2

GENE ID SPECIES
23241 Homo sapiens
217893 Mus musculus
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