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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally we are shipping PACS2 Antibodies (25) and many more products for this protein.
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Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.
cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells
Tumor necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.
subcellular localization and function of polycystin-2 (show PKD2 Proteins) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Proteins)/endosomal system
the phosphorylation state of the calnexin (show CANX Proteins) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane
Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Proteins) cooperates with 14-3-3 (show YWHAQ Proteins) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.
PACS-2 coordinates p53 (show TP53 Proteins)/p21- dependent cell cycle arrest with NF-kappaB (show NFKB1 Proteins)/Bcl-xL (show BCL2L1 Proteins)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.
CS-2 (show MYOZ1 Proteins) traffics to the nucleus where it regulates SIRT1 (show SIRT1 Proteins)-mediated p53 (show TP53 Proteins) deacetylation. PACS-2 binds SIRT1 (show SIRT1 Proteins) in vitro and directly inhibits SIRT1 (show SIRT1 Proteins)-catalyzed p53 (show TP53 Proteins) deacetylation.
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.