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Members of the Rho GTPase family, such as RND1, regulate the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998 [PubMed 9531558]).[supplied by OMIM, Mar 2008].. Additionally we are shipping RND1 Kits (15) and RND1 Proteins (10) and many more products for this protein.
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The authors propose that anillin is required for proper Rho-GTP distribution at cell-cell junctions and for maintenance of a robust apical actomyosin belt, which is required for cell-cell junction integrity.
Reduced RND1 expression in HCC was associated with cancer progression, likely through regulation of the Ras signaling pathway.
Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.
Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration.
RND1 plays an important role in the progression of esophageal squamous cell carcinoma
These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression
Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa.
role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation
Rnd1 does not play a role in the activation of plexin-C1 and -D1
Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
The RND1 mRNA expression levels increased significantly after gestation in myometria.
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain
SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.
Members of the Rho GTPase family, such as RND1, regulate the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998
Rho family GTPase 1
, GTP-binding protein
, ras-like protein Rnd1b
, rho-related GTP-binding protein Rho6
, ras homolog gene family, member S