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GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Additionally we are shipping ARHGAP10 Antibodies (27) and and many more products for this protein.
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ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways.
In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)).
PS-GAP is a novel regulator of caspase-activated PAK-2
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
PH and SH3 domain-containing rhoGAP protein
, rho GTPase-activating protein 10
, rho-type GTPase-activating protein 10
, Rho GTPase activating protein 10
, GTPase regulator associated with focal adhesion kinase 2
, graf-related protein 2