serine Hydroxymethyltransferase 1 (Soluble) Proteins (SHMT1)

Human serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

1. regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease

2. Methylene tetrahydrofolate reductase (MTHFR) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine.

3. The one-carbon donor formate generally rescues cells from SHMT inhibition, but paradoxically increases the inhibitor's cytotoxicity in diffuse large B-cell lymphoma (DLBCL); this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering them uniquely dependent upon SHMT enzymatic activity to meet glycine demand.

4. The present study, using both case-control and family-based triad approach is the first report to demonstrate parental association of SHMT1 C1420T variant in conferring NTD risk in the fetus.

5. SHMT1 controls the expression of pro-oncogenic inflammatory cytokines by regulating sialic acid Neu5Ac to promote ovarian cancer tumor growth and migration.

6. Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

7. Site-directed mutagenesis experiments on SHMT1 demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (Cys204) that is absent in SHMT2.

8. SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin.

9. we identified SHMT1 as a target gene of miR-198. In conclusion, miR-198 suppressed proliferation of lung adenocarcinoma cells both in vitro and in vivo by directly targeting SHMT1.

10. Rs9901160, rs2273027 as well as rs1979277 polymorphism significantly increased the risk of childhood acute lymphoblastic leukemia.

11. an association between MTRR 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes

12. our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer.

13. SHMT1 knockdown in lung cancer cells leads to cell cycle arrest and to p53-dependent apoptosis.

14. In this meta-analysis, SHMT1 C1420T polymorphism did not have a significant association with the risk of cancer overall.

15. SHMT1 exists in solution as a tetramer, both in the absence and presence of PLP, while SHMT2 undergoes a dimer-to-tetramer transition.

16. found evidence for association of SHMT1 C1420T polymorphism with significantly reduced risk of breast cancer in Asians

17. SHMT1 C1420T polymorphism is not associated with overall cancer development.

18. serine hydroxymethyltransfarase C1420T reduces risk for both acute lymphoblastic leukemia and acute myeloid leukemia and influences disease progression in acute lymphoblastic leukemia

19. SHMT1 C1420T and DNMT3B C46359T polymorphisms are not associated with HNC development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx

20. geography-specific effects of the SHMT1 polymorphism that render Europeans susceptible to colorectal caner, but not Americans.

Mouse (Murine) serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

1. Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice.

2. SHMT1 and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

3. Data show that Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc(min)(/+) mice through a gene-by-diet interaction.

4. These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk.

5. It is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans. (review)

6. Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating prepulse inhibition in mice and possibly relevant to human schizophrenia.

7. mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm

8. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis

Rabbit serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

1. we have expressed, characterized, and determined the crystal structures of rabbit cytosolic serine hydroxymethyltransferase T254A and T254C mutant forms, in the absence and presence of substrates.

Arabidopsis thaliana serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

1. SHM1 and SHM2 operate in a redundant manner in one-carbon metabolism of nonphotorespiring cells with a high demand of one-carbon units.

2. The senescence is initiated in shm1-1 under photorespiratory conditions. Transcription of the senescence marker SAG12 is enhanced in shm1-1.

3. Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.

4. results suggest that UBP16 is involved in salt tolerance in Arabidopsis by modulating sodium transport activity and repressing cell death at least partially through modulating SMH1stability and activity.

5. The characterization and expression of SHMT1 in A. thaliana. [SHMT1]

6. SHM1 expression is required for mitochondrial serine hydroxymethyltransferase activity and proper function of the C2 cycle during growth in ambient air.

7. SHMT1 interacts with GLU1 and this interaction is necessary for photorespiratory serine hydroxymethyltransferase (SHMT) activity.