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serine Hydroxymethyltransferase 1 (Soluble) Proteins (SHMT1)

SHMT1 encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Additionally we are shipping serine Hydroxymethyltransferase 1 (Soluble) Antibodies (69) and serine Hydroxymethyltransferase 1 (Soluble) Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SHMT1 SHMT1 287379  
SHMT1 6470 P34896
SHMT1 20425 P50431
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Top serine Hydroxymethyltransferase 1 (Soluble) Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
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Yeast Encephalitozoon cuniculi His tag   1 mg Log in to see 60 to 71 Days
$3,294.50
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Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$3,366.00
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Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,366.00
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,366.00
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Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$600.88
Details

SHMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine)

More Proteins for serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) Interaction Partners

Human serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. Methylene tetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR (show MTR Proteins)) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR (show MTRR Proteins)) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS (show TYMS Proteins) 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine.

  2. The one-carbon donor formate generally rescues cells from SHMT inhibition, but paradoxically increases the inhibitor's cytotoxicity in diffuse large B-cell lymphoma (DLBCL); this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering them uniquely dependent upon SHMT enzymatic activity to meet glycine demand.

  3. The present study, using both case-control and family-based triad approach is the first report to demonstrate parental association of SHMT1 C1420T variant in conferring NTD risk in the fetus.

  4. SHMT1 controls the expression of pro-oncogenic inflammatory cytokines by regulating sialic acid Neu5Ac to promote ovarian cancer tumor growth and migration.

  5. Site-directed mutagenesis experiments on SHMT1 demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (Cys204) that is absent in SHMT2 (show SHMT2 Proteins).

  6. SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin.

  7. we identified SHMT1 as a target gene of miR (show MLXIP Proteins)-198. In conclusion, miR (show MLXIP Proteins)-198 suppressed proliferation of lung adenocarcinoma cells both in vitro and in vivo by directly targeting SHMT1.

  8. an association between MTRR (show MTRR Proteins) 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes

  9. our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer.

  10. SHMT1 knockdown in lung cancer cells leads to cell cycle arrest and to p53 (show TP53 Proteins)-dependent apoptosis.

Mouse (Murine) serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice.

  2. SHMT1 and TYMS (show TYMS Proteins) localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Data show that Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc (show APC Proteins)(min)(/+) mice through a gene-by-diet interaction.

  4. These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk.

  5. Shmt1 (SHMT1), but not Srr (show SRR Proteins), is likely to be one of the genetic components regulating prepulse inhibition in mice and possibly relevant to human schizophrenia.

  6. mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm

  7. SHMT1 and SHMT2 (show SHMT2 Proteins) are functionally redundant in nuclear de novo thymidylate biosynthesis

Rabbit serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. we have expressed, characterized, and determined the crystal structures of rabbit cytosolic serine hydroxymethyltransferase T254A and T254C mutant forms, in the absence and presence of substrates.

Arabidopsis thaliana serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. SHM1 and SHM2 operate in a redundant manner in one-carbon metabolism of nonphotorespiring cells with a high demand of one-carbon units.

  2. The senescence is initiated in shm1-1 under photorespiratory conditions. Transcription of the senescence marker SAG12 is enhanced in shm1-1.

  3. Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.

  4. The characterization and expression of SHMT1 in A. thaliana. [SHMT1]

  5. SHM1 expression is required for mitochondrial serine hydroxymethyltransferase (show SHMT2 Proteins) activity and proper function of the C2 cycle during growth in ambient air.

  6. SHMT1 interacts with GLU1 and this interaction is necessary for photorespiratory serine hydroxymethyltransferase (SHMT) activity.

serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) Protein Profile

Protein Summary

This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with SHMT1

  • serine hydroxymethyltransferase 1 (Shmt1)
  • serine hydroxymethyltransferase 1 (soluble) L homeolog (shmt1.L)
  • serine hydroxymethyltransferase 1 (soluble) (shmt1)
  • microRNA 6778 (MIR6778)
  • serine hydroxymethyltransferase 1 (SHMT1)
  • serine hydroxymethyltransferase 1 (soluble) (Shmt1)
  • serine transhydroxymethyltransferase 1 (SHM1)
  • AI324848 protein
  • AI385541 protein
  • C81125 protein
  • CSHMT protein
  • F20D10.50 protein
  • F20D10_50 protein
  • LRRGT00032 protein
  • MEL-32 protein
  • MGC53442 protein
  • mshmt protein
  • mshmt1 protein
  • mshmt2 protein
  • SERINE HYDROXYMETHYLTRANSFERASE 1 protein
  • SERINE TRANSHYDROXYMETHYLASE protein
  • SERINE TRANSHYDROXYMETHYLTRANSFERASE protein
  • serine transhydroxymethyltransferase 1 protein
  • SHMT protein
  • Shmt1 protein
  • SHMT2 protein
  • STM protein
  • zgc:66171 protein
  • zgc:77524 protein

Protein level used designations for SHMT1

serine hydroxymethyltransferase, cytosolic , serine hydroxymethyltransferase 1 (soluble) , zSHMT-1 , SHMT , glycine hydroxymethyltransferase , serine methylase , cytoplasmic serine hydroxymethyltransferase , cytosolic serine hydroxymethyltransferase , serine hydroxymethyl transferase , serine hydroxymethyltransferase 2 (mitochondrial)

GENE ID SPECIES
287379 Rattus norvegicus
380048 Xenopus laevis
394021 Danio rerio
416520 Gallus gallus
454490 Pan troglodytes
489536 Canis lupus familiaris
548668 Xenopus (Silurana) tropicalis
100117303 Nasonia vitripennis
100159628 Acyrthosiphon pisum
100171460 Pongo abelii
100600675 Nomascus leucogenys
6470 Homo sapiens
20425 Mus musculus
100009405 Oryctolagus cuniculus
443544 Ovis aries
509002 Bos taurus
829949 Arabidopsis thaliana
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