serine Hydroxymethyltransferase 2 (Mitochondrial) Proteins (SHMT2)

SHMT2 encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate.

list all proteins Gene Name GeneID UniProt
Human SHMT2 SHMT2 6472 P34897
Mouse SHMT2 SHMT2 108037  
Rat SHMT2 SHMT2 299857  
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Top SHMT2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,340.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,340.33
Details
Yeast REACT_Potato His tag   1 mg Log in to see 60 to 71 Days
$3,377.00
Details
Yeast REACT_Pea His tag   1 mg Log in to see 60 to 71 Days
$3,377.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$688.00
Details

More Proteins for serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) Interaction Partners

Human serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) interaction partners

  1. The one-carbon donor formate generally rescues cells from SHMT (show SHMT1 Proteins) inhibition, but paradoxically increases the inhibitor's cytotoxicity in diffuse large B-cell lymphoma (DLBCL); this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering them uniquely dependent upon SHMT (show SHMT1 Proteins) enzymatic activity to meet glycine demand.

  2. Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 and ASCT2 (show SLC1A5 Proteins) as valuable individual prognostic markers and potential targets for personalized breast cancer therapy

  3. Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  4. High SHMT2 expression is associated with idiopathic pulmonary fibrosis.

  5. Site-directed mutagenesis experiments on SHMT1 (show SHMT1 Proteins) demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (show SHMT1 Proteins) (Cys204) that is absent in SHMT2.

  6. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases

  7. our results for the first time showed that miR (show MLXIP Proteins)-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC (show FAM126A Proteins).

  8. The SHMT-2 is the direct targets of miR (show MLXIP Proteins)-370 and miR (show MLXIP Proteins)-373, respectively, in human articular chondrocytes.

  9. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth.

  10. SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition

Mouse (Murine) serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) interaction partners

  1. SHMT1 (show SHMT1 Proteins) and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis

SHMT2 Protein Profile

Protein Summary

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SHMT2

  • serine hydroxymethyltransferase 2 (mitochondrial) (Chro.80302)
  • serine hydroxymethyltransferase 2 (mitochondrial) (shmt2)
  • serine hydroxymethyltransferase 2 (mitochondrial) L homeolog (shmt2.L)
  • serine hydroxymethyltransferase 2 (SHMT2)
  • serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2)
  • serine hydroxymethyltransferase 2 (Shmt2)
  • 2700043D08Rik protein
  • AA408223 protein
  • AA986903 protein
  • GLYA protein
  • SHMT protein

Protein level used designations for SHMT2

serine hydroxymethyltransferase 2 (mitochondrial) , mitochondrial serine hydroxymethyltransferase , serine hydroxymethyltransferase, mitochondrial , GLY A+ , glycine auxotroph A, human complement for hamster , glycine hydroxymethyltransferase , serine aldolase , serine hydroxymethylase , serine methylase , threonine aldolase , SHMT

GENE ID SPECIES
3412258 Cryptosporidium hominis TU502
100144628 Danio rerio
447193 Xenopus laevis
6472 Homo sapiens
607458 Canis lupus familiaris
507197 Bos taurus
100009293 Oryctolagus cuniculus
108037 Mus musculus
299857 Rattus norvegicus
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