serine Hydroxymethyltransferase 2 (Mitochondrial) Proteins (SHMT2)

SHMT2 encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Additionally we are shipping SHMT2 Antibodies (38) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SHMT2 6472 P34897
Mouse SHMT2 SHMT2 108037  
Rat SHMT2 SHMT2 299857  
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Top SHMT2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 11 Days
$284.90
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,340.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,340.33
Details
Yeast REACT_Pea His tag   1 mg Log in to see 60 to 71 Days
$3,377.00
Details
Yeast REACT_Potato His tag   1 mg Log in to see 60 to 71 Days
$3,377.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$688.00
Details

SHMT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) Interaction Partners

Human serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) interaction partners

  1. serine hydroxymethyltransferase 2 (SHMT2) is acetylated at K95 in colorectal cancer (CRC) cells. SHMT2-K95-Ac disrupts its functional tetramer structure and inhibits its enzymatic activity. SHMT2-K95-Ac promotes its degradation via the K63-ubiquitin-lysosome pathway in a glucose-dependent manner. SHMT2-K95-Ac is decreased in human CRC samples which is correlated with poorer postoperative overall survival.

  2. Findings support the hypothesis that age-associated respiration defects in fibroblasts of elderly humans are caused not by mtDNA mutations but by epigenetic regulation of nuclear genes including SHMT2.

  3. SHMT2 Desuccinylation is associated with Cancer Cell Proliferation.

  4. The one-carbon donor formate generally rescues cells from SHMT inhibition, but paradoxically increases the inhibitor's cytotoxicity in diffuse large B-cell lymphoma (DLBCL); this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering them uniquely dependent upon SHMT enzymatic activity to meet glycine demand.

  5. Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 and ASCT2 as valuable individual prognostic markers and potential targets for personalized breast cancer therapy

  6. Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC).

  7. High SHMT2 expression is associated with idiopathic pulmonary fibrosis.

  8. Site-directed mutagenesis experiments on SHMT1 demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (Cys204) that is absent in SHMT2.

  9. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases

  10. our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC.

  11. The SHMT-2 is the direct targets of miR-370 and miR-373, respectively, in human articular chondrocytes.

  12. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth.

  13. SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition

  14. SHMT1 exists in solution as a tetramer, both in the absence and presence of PLP, while SHMT2 undergoes a dimer-to-tetramer transition.

  15. The present study not only describes individual genetic variation that directly affects SHMT1 and SHMT2 activity, but provided insight into the overall regulation of the Folate and Methionine Cycles.

  16. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis

  17. This paper compares the mitochondrial and cytoplasmic forms of this enzyme and suggests that the two genes are a result of a single gene duplication.

Mouse (Murine) serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) interaction partners

  1. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis

SHMT2 Protein Profile

Protein Summary

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SHMT2

  • serine hydroxymethyltransferase 2 (SHMT2)
  • serine hydroxymethyltransferase 2 (mitochondrial) (Chro.80302)
  • serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2)
  • serine hydroxymethyltransferase 2 (Shmt2)
  • serine hydroxymethyltransferase 2 (mitochondrial) (shmt2)
  • serine hydroxymethyltransferase 2 (mitochondrial) L homeolog (shmt2.L)
  • serine hydroxymethyltransferase, mitochondrial-like (SHMT)
  • 2700043D08Rik protein
  • AA408223 protein
  • AA986903 protein
  • GLYA protein
  • SHMT protein

Protein level used designations for SHMT2

GLY A+ , glycine auxotroph A, human complement for hamster , glycine hydroxymethyltransferase , serine aldolase , serine hydroxymethylase , serine hydroxymethyltransferase, mitochondrial , serine methylase , threonine aldolase , SHMT , serine hydroxymethyltransferase 2 (mitochondrial) , mitochondrial serine hydroxymethyltransferase , Glycine hydroxymethyltransferase , Serine methylase

GENE ID SPECIES
6472 Homo sapiens
507197 Bos taurus
3412258 Cryptosporidium hominis TU502
108037 Mus musculus
299857 Rattus norvegicus
100144628 Danio rerio
447193 Xenopus laevis
607458 Canis lupus familiaris
100009293 Oryctolagus cuniculus
100725949 Cavia porcellus
102591486 Solanum tuberosum
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