serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) ELISA Kits

Human serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

1. 3 siblings with near identical clinical manifestations of early onset acute recurrent pancreatitis (ARP (show CRISP1 ELISA Kits)), all possessing the same heterozygous for serine protease inhibitor, Kazal type 1 (SPINK1) mutation c.55+1G>A.

2. We demonstrate for the first time a significant decrease of SPINK1 levels after surgical decompression of pancreatic duct and a reduction of trypsin activity analysis after endoscopic decompression

3. SPINK1 over expression is associated with prostate cancer specific mortality in at risk men with biochemical and clinical recurrence after prostatectomy

4. Data show that alteration in beta-catenin (show CTNNB1 ELISA Kits) expression, a core component of the CDH17/beta-catenin (show CTNNB1 ELISA Kits) axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC) patients.

5. Findings indicate that the serine protease inhibitor, Kazal type 1 (SPINK1) p.N34S allele may cause reduced SPINK1 expression.

6. Having correlated our findings with current knowledge of SPINK1's role in exocrine pancreas pathophysiology, we propose that complete and partial functional losses of the SPINK1 gene are associated with quite distinct phenotypes, the former causing a new pediatric disease entity of severe infantile isolated exocrine pancreatic insufficiency (EPI (show TFPI ELISA Kits)) .

7. results suggest that rs142703147:C>A, which disrupts a PTF1L-binding site within an evolutionarily conserved HNF1A (show HNF1A ELISA Kits)-PTF1L cis-regulatory module located upstream of the SPINK1 promoter, contributes to the chronic pancreatitis risk haplotype.

8. Studied mutations in cationic trypsinogen (PRSS1 (show PRSS1 ELISA Kits)) and serine protease inhibitor Kazal type 1 (SPINK1) and their association with alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis.

9. Studies indicate that serine peptidase inhibitor Kazal type 1 (SPINK1) gene, particularly the N34S mutation, has a genetic association with the development of pancreatitis [Meta-analysis].

10. association between SPINK1 p.N34S gene variation and chronic pancreatitis [review, meta-analysis]

Cow (Bovine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

1. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.

Mouse (Murine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

1. It is a trypsin-specific inhibitor in the pancreas.

2. IFN regulatory factor 2 (Irf2 (show IRF2 ELISA Kits)) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK3 ELISA Kits)

3. SPINK3 modulates sperm physiology through a downstream reduction of endogenous NO concentration and independently of SPINK3 trypsin inhibitory activity.

4. uterine-gland-derived SPINK3 (show SPINK3 ELISA Kits), as a new paracrine modulator, might play an important role in embryo implantation through its influence on stromal decidualization in mice.

5. Spink3 (show SPINK3 ELISA Kits) may act as a growth factor, leading to cell proliferation and regeneration of tissue structure.

6. Results suggest that regulation of Prss1 (show PRSS1 ELISA Kits) and Spink3 (show SPINK3 ELISA Kits) expression is involved in the susceptibility to experimentally induced pancreatitis.

7. Spink3 (show SPINK3 ELISA Kits) trypsin inhibitor is required for normal pancreatic development. Data indicate an important relationship between endogenous pancreatic trypsin and Spink3 (show SPINK3 ELISA Kits) and the development of pancreatitis.

8. SPINK3 (show SPINK3 ELISA Kits) mRNA is upregulated in chronic pancreatitis.

9. Spink3 (show SPINK3 ELISA Kits) may play important roles in proliferation and/or differentiation of various cell types during development.