serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) Proteins (SPINK2)

SPINK2 encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK).

list all proteins Gene Name GeneID UniProt
Mouse SPINK2 SPINK2 69982 Q8BMY7
Human SPINK2 SPINK2 6691 P20155
Rat SPINK2 SPINK2 408234 Q6IE49
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Top SPINK2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$437.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$2,051.50
Details

More Proteins for serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) (SPINK2) Interaction Partners

Mouse (Murine) serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) (SPINK2) interaction partners

  1. Overexpression of different variants of Spink2 in D407 tissue culture cells increases their susceptibility to the apoptosis-inducing agent staurosporine in a manner consistent with the differential susceptibility between the DBA (show RPS19 Proteins)/2J and BALB/cByJ strains

  2. SPINK2 is required for maintaining normal spermatogenesis and potentially regulates serine protease (show F2 Proteins)-mediated apoptosis in male germ cells.

Human serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) (SPINK2) interaction partners

  1. These results demonstrate that SPINK2 is necessary to neutralize proteases during their cellular transit toward the acrosome and that its deficiency induces a pathological continuum ranging from oligoasthenoteratozoospermia in heterozygotes to azoospermia in homozygotes.

  2. Data showed that the expression level of SPINK2 is significantly elevated in most leukemia cell lines except B-lymphoblast TK-6 cells. Data demonstrated that Arg(24) at the P1 site is crucial for the specificity of SPINK2 on target enzyme.

SPINK2 Protein Profile

Protein Summary

This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SPINK2

  • serine peptidase inhibitor, Kazal type 2 (Spink2)
  • serine peptidase inhibitor, Kazal type 2 (SPINK2)
  • serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) (Spink2)
  • 1700007F22Rik protein
  • AV038945 protein
  • HUSI-II protein

Protein level used designations for SPINK2

acrosin-trypsin inhibitor , serine protease inhibitor Kazal-type 2 , serine protease inhibitor, Kazal type 2 , epididymis tissue protein Li 172 , Kazal type serine protease inhibitor 2 , serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

GENE ID SPECIES
69982 Mus musculus
6691 Homo sapiens
408234 Rattus norvegicus
767993 Bos taurus
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