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SPINK2 encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK).
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Overexpression of different variants of Spink2 in D407 tissue culture cells increases their susceptibility to the apoptosis-inducing agent staurosporine in a manner consistent with the differential susceptibility between the DBA (show RPS19 Proteins)/2J and BALB/cByJ strains
SPINK2 is required for maintaining normal spermatogenesis and potentially regulates serine protease (show F2 Proteins)-mediated apoptosis in male germ cells.
These results demonstrate that SPINK2 is necessary to neutralize proteases during their cellular transit toward the acrosome and that its deficiency induces a pathological continuum ranging from oligoasthenoteratozoospermia in heterozygotes to azoospermia in homozygotes.
Data showed that the expression level of SPINK2 is significantly elevated in most leukemia cell lines except B-lymphoblast TK-6 cells. Data demonstrated that Arg(24) at the P1 site is crucial for the specificity of SPINK2 on target enzyme.
This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants.
, serine protease inhibitor Kazal-type 2
, serine protease inhibitor, Kazal type 2
, epididymis tissue protein Li 172
, Kazal type serine protease inhibitor 2
, serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)