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STK39 encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. Additionally we are shipping STK39 Antibodies (191) and STK39 Proteins (7) and many more products for this protein.
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STK39 acts as a tumor oncogene (show RAB1A ELISA Kits) in non-small cell type lung cancer and can be a potential biomarker of carcinogenesis.
In conclusion, these meta-analytical findings suggest that STK39 might not be a hypertension-susceptibility gene.
Here, we report our replication data showing a significant association of the rs3754777 polymorphism, but not rs35929607, of STK39 with essential hypertension in a male Chinese Han population.
Both SPAK and OSR1 (show OXSR1 ELISA Kits) kinases entering cells through exosomes are preferentially expressed at the plasma membrane and that the kinases in exosomes are functional and maintain NKCC1 (show SLC12A2 ELISA Kits) in a phosphorylated state.
did not observe any significant difference in allele and genotype distribution between Parkinson's disease patients and controls for rs1955337 in STK39
SPAK and OSR1 are both stimulators of Kir2.1 activity.
SPAK and OSR1 are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb
Single nucleotide polymorphisms STK39 and WNK1 (show WNK1 ELISA Kits) were associated with hypertension and BP in our multicenter Belgian case-control study
STK39 mRNA and protein express abnormally in primary hypertension patients with genetic variation, which is related to the blood pressure.
SPAK protein has both the potential to up-regulate KCNQ1 (show KCNQ1 ELISA Kits)/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism.
SPAK plays a pathogenic role in IgA (show IgA ELISA Kits) nephropathy through the activation of NF-kappaB (show NFKB1 ELISA Kits)/MAPK (show MAPK1 ELISA Kits) signaling pathway.
Here, we show that specific expression of CA-SPAKwithin the early distal convoluted tubule (DCT1 (show SLC11A2 ELISA Kits)) drives FHHt.
Our data reveal that together SPAK and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium
Genetic depletion of SPAK kinase reduces ischemic brain injury after occlusion of the left middle cerebral artery.
the increased NCC (show SLC12A3 ELISA Kits) expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK signal pathway using WNK4-/- and SPAK-/- mice.
We conclude that TRPV2 (show TRPV2 ELISA Kits) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK-activated NKCC1 (show SLC12A2 ELISA Kits)
SPAK has the potential to up-regulate ENaC (show SCNN1A ELISA Kits)
These observations establish that the CCT domain plays a crucial role in controlling SPAK activity and BP.
The data of this study supported the gene-environment hypothesis and demonstrated the potential value of SPAK manipulation in future schizophrenia studies.
The structure of partially active SPAK T243D is consistent with a multistage activation process in which phosphorylation induces a SPAK conformation that requires further remodeling to build the active structure.
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
serine threonine kinase 39 (STE20/SPS1 homolog)
, serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
, serine threonine kinase 39
, serine/threonine kinase 39
, STE20/SPS1 homolog
, STE20/SPS1-related proline-alanine-rich protein kinase
, Ste20-like protein kinase
, proline-alanine-rich STE20-related kinase
, serine/threonine-protein kinase 39
, small intestine SPAK-like kinase
, ste-20-related kinase
, Ste-20 related kinase
, pancreatic serine/threonine-protein kinase
, kidney-specific SPAK
, serine/threonine kinase 39, STE20/SPS1 homolog